Results 71 to 80 of about 123,617 (236)

Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest

Frontiers in Human Neuroscience, 2017
Cross-frequency coupling (CFC) between slow and fast brain rhythms, in the form of phase–amplitude coupling (PAC), is proposed to enable the coordination of neural oscillatory activity required for cognitive processing.
Catherine M. Sweeney-Reed, Tino Zaehle, Jürgen Voges, Jürgen Voges, Friedhelm C. Schmitt, Lars Buentjen, Viola Borchardt, Martin Walter, Martin Walter, Hermann Hinrichs, Hermann Hinrichs, Hermann Hinrichs, Hans-Jochen Heinze, Hans-Jochen Heinze, Hans-Jochen Heinze, Michael D. Rugg, Robert T. Knight   +16 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A critical note on the definition of phase–amplitude cross-frequency coupling

Journal of Neuroscience Methods, 2011
Recent studies have observed the ubiquity of phase-amplitude coupling (PAC) phenomenon in human and animal brain recordings. While various methods were performed to quantify it, a rigorous analytical definition of PAC is lacking. This paper yields an analytical definition and accordingly offers theoretical insights into some of the current methods.
Ozkurt, Tolga Esat, Schnitzler, Alfons
openaire   +3 more sources

Simulation analysis and experimental study on high frequency friction noise of vehicle V-ribbed belts

Measurement + Control, 2020
In order to improve the service life of the V-ribbed belt and the ride comfort of the vehicle, the friction noise of V-ribbed belt was studied by simulation and experiment.
Yaochen Shi, Tianxiang Zhao, Kai Ning, Wusheng Tang   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Design of W band rectangular waveguide filter

Dianzi Jishu Yingyong, 2018
To study the relationship between the performance and the size of the filter, a W band rectangular waveguide bandpass filter with cross-coupling structure is designed. The cross-coupling structure reduces the rectangular coefficient by 25.7% and enhances
Bai Qiong, Zhang Binzhen, Duan Junping
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source