Results 71 to 80 of about 543,959 (260)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Control of the photodetachment of H- in a gradient electric field by an elastic surface

open access: yes四川大学学报. 自然科学版, 2016
The photodetachment of H- in a gradient electric field near an elastic surface has been studied on the basis of the closed-orbit theory, especially discuss the influence of the elastic surface on the photodetachment cross section of H- in a gradient ...
YU Yong-Jiang   +2 more
doaj  

Multistage Training and Fusion Method for Imbalanced Multimodal UAV Remote Sensing Classification

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In remote sensing applications, autonomous aerial vehicles (AAVs) overcome the limitations of single-sensor approaches by integrating multiple sensors and fusing cross-modal data, significantly improving target classification accuracy.
Shihao Wang, Zhengwei Xu, Yun Lin
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

CSIFT: A Structural Feature Encoding Framework for Cross-Modal Image Registration

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Multimodal sensor collaborative detection serves as an indispensable complementary technology in Earth observation. However, significant cross-modal discrepancies in multimodal images severely limit the operational efficiency and alignment accuracy of ...
Lipeng Lian, Leping Chen, Daoxiang An
doaj   +1 more source

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