Results 61 to 70 of about 543,959 (260)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

QRS detection using K-Nearest Neighbor algorithm (KNN) and evaluation on standard ECG databases

Journal of Advanced Research, 2013
The performance of computer aided ECG analysis depends on the precise and accurate delineation of QRS-complexes. This paper presents an application of K-Nearest Neighbor (KNN) algorithm as a classifier for detection of QRS-complex in ECG.
Indu Saini, Dilbag Singh, Arun Khosla
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The measurement of thermal changes on concrete box girder bridge

MATEC Web of Conferences, 2016
Thermal load, especially vertical temperature gradient is an important factor that should be considered during the bridge design procedure. In the world several researches focusing on thermal influences was performed, mostly in USA and China, but only a ...
Krkoška Lukáš, Moravčík Martin
doaj   +1 more source

Case studies of 2D cross gradient joint inversion of seismic refraction and DC resistivity data: Potential and limitations [PDF]

E3S Web of Conferences
Seismic refraction tomography (SRT) and electrical resistivity tomography (ERT) 2D profiles are commonly employed in near surface geophysical surveys to gather subsurface information.
Seive Benjamin, Boulay Antonin
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effect of variable thickness cross rolling on microstructure gradient of 2205 duple stainless steel

Journal of Materials Research and Technology
Quantitative description of the complex relationship between rolling process and microstructure is crucial for improving the performance of 2205 duplex stainless steel products.
Xiaojun Wang, Yafeng Ji, Jing Niu, Xu Li
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Determining the Influence of Sample Thickness on the High-Temperature Drying of Beech Wood (Fagus sylvatica L.)

BioResources, 2016
Drying time reduction has always been a major concern in the drying process and is achievable by increasing the temperature of the surrounding air. To optimize the quality of the resulting material, drying conditions must be enhanced to reach a balanced ...
Ivan Klement, Tatiana Huráková
doaj   +1 more source