Results 171 to 180 of about 4,936,875 (304)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Bifunctional Lipid-Protein Cross-linking Efficiency and Reaction Products. [PDF]

J Am Chem Soc
Kirschbaum C, Lennartz HM, Cook KC, Böhlig K, Papangelis A, Robinson CV, Nadler A.   +6 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Refractive Index Engineering for Human Corneal Tissue by Femtosecond Laser Two-Photon Cross-Linking. [PDF]

J Biophotonics
Qi P, Zhou Z, An J, Liu H, Zhang Y, Liu H, Chang L, Wu Y, Wang Y, Kosareva O, Savel'ev A, Lin L, Liu W.   +12 more
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Transient Endothelial Damage Following FS-LASIK Combined With Corneal Cross-Linking Surgery: Case Report. [PDF]

Am J Case Rep
Wang L, Wang Y, Zhang X.
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Mapping the architecture of protein complexes in <i>Arabidopsis</i> using cross-linking mass spectrometry. [PDF]

Proc Natl Acad Sci U S A
Trinh CS, Shrestha R, Mao P, Conner WC, Reyes AV, Karunadasa SS, Yu A, Liu G, Hu K, Xu SL.   +9 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Ambient light drives verteporfin-induced protein cross-linking during standard laboratory sample processing. [PDF]

PLoS One
Baroutis KG, Corrêa VSMC, Ntentakis D, Narimatsu T, Gragoudas ES, Miller JW, Young LH, Vavvas DG.   +7 more
europepmc   +1 more source