Results 51 to 60 of about 183,904 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

In situ self cross-linking of polyvinyl alcohol battery separators [PDF]

, 1979
A battery separator was produced from a polyvinyl alcohol sheet structure which was subjected to an in situ, self crosslinking process by selective oxidation of the 1,2 diol units present in the polyvinyl alcohol sheet structure.
Hsu, L. C., Philipp, W. H., Sheibley, D. W.   +2 more
core   +1 more source

Liesegang patterns: Effect of dissociation of the invading electrolyte

, 1998
The effect of dissociation of the invading electrolyte on the formation of Liesegang bands is investigated. We find, using organic compounds with known dissociation constants, that the spacing coefficient, 1+p, that characterizes the position of the n-th
Antal T., Chopard B., Dee G. T., Dhar N. R., Feeney R., Flicker M., Gálfi L., Henisch H. K., Jablczynski K., Kai S., Liesegang R. E., Matalon R., Morse W., Ostwald W., Packter A., Prager S., Shinohara S., Smith D. A., Venzl G., Wagner C., Zeldovitch Ya. B., Zrinyi M.   +21 more
core   +1 more source

Heterobifunctional reagents for cross-linking of sugar with protein.

Chemical and Pharmaceutical Bulletin, 1985
N-Bromoacetylsulfanilyl chloride and p-bromoacetamidobenzoyl chloride were synthesized as heterobifunctional reagents for the cross-linking of sugar with protein. These reagents react with the primary hydroxyl group of a sugar at the acid chloride group and with amino and imidazole groups of protein at the bromoacetyl group.
M, Ohnishi, H, Sugimoto, H, Yamada, T, Imoto, K, Zaitsu, Y, Ohkura   +5 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Efficiency of Polyester-Polysulfone Membranes, Coated with Crosslinked PVA Layers, in the Water Desalination by Pervaporation

Membranes
Composite polymer membranes were obtained using the so-called dry phase inversion and were used for desalination of diluted saline water solutions by pervaporation (PV) method.
Izabela Gortat, Jerzy J. Chruściel, Joanna Marszałek, Renata Żyłła, Paweł Wawrzyniak   +4 more
doaj   +1 more source

How does Cross-Linking Effect the Thermal Stability of Polyisoprene [PDF]

, 2000
Polyisoprene can be cross-linked by an initial lithiation followed by reaction with both monochloro compounds and dichloro compounds. The monochloro compounds effect crosslinking through a lithium-chlorine exchange route while the use of dichloro ...
Wilkie, Charles A., Yao, Qiang
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Gelation and Cryogelation of Chitosan: Origin of Low Efficiency of Diglycidyl Ethers as Cross-Linkers in Acetic Acid Solutions

Polysaccharides
Although diglycidyl ethers of glycols (DEs)—FDA-approved reagents for biomedical applications—were considered unsuitable for the fabrication of chitosan (CH) hydrogels and cryogels, we have recently shown that CH cross-linking with DEs is possible, but ...
Yuliya Privar, Anna Skatova, Alexey Golikov, Andrey Boroda, Svetlana Bratskaya   +4 more
doaj   +1 more source