Results 51 to 60 of about 4,667,155 (305)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Heterobifunctional reagents for cross-linking of sugar with protein.

Chemical and Pharmaceutical Bulletin, 1985
N-Bromoacetylsulfanilyl chloride and p-bromoacetamidobenzoyl chloride were synthesized as heterobifunctional reagents for the cross-linking of sugar with protein. These reagents react with the primary hydroxyl group of a sugar at the acid chloride group and with amino and imidazole groups of protein at the bromoacetyl group.
OHNISHI, MIKIO, SUGIMOTO, HIROYUKI, YAMADA, HIDENORI, IMOTO, TAIJI, ZAITSU, KIYOSHI, OHKURA, YOSUKE   +5 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Synthesis of Bioconjugation Reagents for Use in Covalent Cross-Linking of Proteins by Azide-Alkyne Cycloaddition

Molecules
A series of azide- and cyclooctyne-functionalized N-hydroxysuccinimidyl esters (NHS esters) and benzotriazolides were prepared and used as N-acylation reagents to obtain azide-(BSA-1) and cyclooctyne-functionalized bovine serum albumin proteins (BSA-2 ...
Nadja Suhorepec, Luka Ciber, Uroš Grošelj, Nejc Petek, Bogdan Štefane, Marko Novinec, Jurij Svete   +6 more
doaj   +1 more source

Combinatorial Electrostatic Collision-Induced Dissociative Chemical Cross-linking Reagents for Probing Protein Surface Topology

, 2016
To ascertain more information on protein domain orientation and complex structure associations using chemical cross-linking, we have developed a combination of electrostatic collision-induced dissociative cross-linking reagents that differentially react ...
Michael B. Goshe (2015989), Fan Liu (27437)   +1 more
core   +1 more source

Ion-Cross-Linking-Promoted High-Performance Si/PEDOT:PSS Electrodes: The Importance of Cations’ Ionic Potential and Softness Parameters

, 2020
PEDOT:PSS has been studied as a silicon-based binder due to its inherent superior electricity and electrochemical stability. However, it cannot effectively alleviate the huge volume changes of silicon during lithiation/delithiation due to its linear ...
Nazakat Ali (8714751), Asma Iqbal (333585), Rongrong Qi (3991094), Xuejiao Liu (838522), Xuefeng Qian (1465711)   +4 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Efficiency of Polyester-Polysulfone Membranes, Coated with Crosslinked PVA Layers, in the Water Desalination by Pervaporation

Membranes
Composite polymer membranes were obtained using the so-called dry phase inversion and were used for desalination of diluted saline water solutions by pervaporation (PV) method.
Izabela Gortat, Jerzy J. Chruściel, Joanna Marszałek, Renata Żyłła, Paweł Wawrzyniak   +4 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Gelation and Cryogelation of Chitosan: Origin of Low Efficiency of Diglycidyl Ethers as Cross-Linkers in Acetic Acid Solutions

Polysaccharides
Although diglycidyl ethers of glycols (DEs)—FDA-approved reagents for biomedical applications—were considered unsuitable for the fabrication of chitosan (CH) hydrogels and cryogels, we have recently shown that CH cross-linking with DEs is possible, but ...
Yuliya Privar, Anna Skatova, Alexey Golikov, Andrey Boroda, Svetlana Bratskaya   +4 more
doaj   +1 more source