Results 141 to 150 of about 2,473,401 (250)

Revisiting the role of negative affect in alcohol use disorder: A longitudinal evaluation of Koob's allostatic model. [PDF]

Psychol Addict Behav
Jackson IF, Cao R, Peng Z, Sher KJ, Watts AL.   +4 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The effect of timing of physical exercise on glycemia: a systematic review and meta-analysis of human intervention studies. [PDF]

J Diabetes Metab Disord
Schipper SBJ, Slebe R, Schoonmade LJ, Blondin DP, Campbell DJT, Carpentier AC, Després JP, Hoeks J, Kalsbeek A, Raina P, Schrauwen P, Serlie MJ, Stenvers DJ, Yi CX, de Mutsert R, Beulens JWJ, Rutters F.   +16 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effects of Menopausal Hormone Therapy on Uterine Fibroids in Women During Menopausal Transition. [PDF]

Int J Womens Health
Huang M, Chen J, Gu L, Yang Y, Qin P.
europepmc   +1 more source

Μελέτες διασταυρούμενης μετάβασης (cross over studies)

, 2010
Η πλειοψηφία των μελετών που χρησιμοποιούνται στις μετα-αναλύσεις είναι τυχαιοποιημένες δοκιμές παράλληλων ομάδων. Υπάρχει όμως και μια άλλη κατηγορία τυχαιοποιημένων μελετών που είναι οι μελέτες διασταυρούμενης μετάβασης. Για τις μελέτες αυτές που παρουσιάζουν ιδιαιτερότητες, τόσο μεθοδολογικές όσο και στατιστικής ανάλυσης, δεν υπάρχει καθιερωμένη ...
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Simple Superior Inverted Flap Technique with Extended Internal Limiting Membrane Peeling for the Treatment of Large Macular Holes. [PDF]

Clin Ophthalmol
Bajdik B, Kemenes G, Jain V, Noronha KM, Fodor M, Takács L.   +5 more
europepmc   +1 more source

Single Dose Cross‐over Theophylline Bioavailability Study

International Journal of Clinical Practice, 1983
S E, Walker, T W, Paton, J, Iazzetta
openaire   +2 more sources