Results 161 to 170 of about 10,849,876 (337)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

[Project Summary: Air Quality and Dispersion Meteorology over the Northeastern Gulf of Mexico: Measurements, Analyses, and Syntheses]

, 2000
Summary describing the work completed at Coastal Studies Institute for "Air Quality and Dispersion Meteorology over the Northeastern Gulf of Mexico: Measurements, Analyses, and Syntheses." It includes background information on the project funding and ...
Coastal Studies Institute
core  

Randomized phase II trial comparing molecularly targeted therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: cross-over analysis from the SHIVA trial

Annals of Oncology, 2016
Lisa Belin, M. Kamal, C. Mauborgne, C. Plancher, F. Mulot, J. Delord, A. Gonçalves, C. Gavoille, C. Dubot, Nicolas Isambert, M. Campone, O. Trédan, Francesco Ricci, M. Alt, D. Loirat, M. Sablin, X. Paoletti, V. Servois, C. Tourneau, C. Tourneau   +19 more
semanticscholar   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Asian American Studies Protest video

UCI student protest that occurred in April 1993 over the absence of an Asian American Studies Program. Over 200 students rallied outside the administration building (Aldrich Hall) and then marched inside.
Department of Asian American Studies
core  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Holy Cross Magazine, Vol. 36, No. 2, Spring 2002

, 2002
The New Jesuits Most of them share Latin Mass as a childhood memory, the priest with his back to the congregation. But for all of them, having been ordained in the aftermath of the Second Vatican Council, when they’ve presided over Mass themselves, it ...
College of the Holy Cross
core  

Inorganic phosphate additives in meals and adaptations to 5-days of dietary inorganic phosphate loading alter acute calcium homeostasis in two randomized cross-over studies in healthy adults. [PDF]

JBMR Plus
Turner ME, Mazzetti T, Neville K, Ward EC, Munroe J, Adams MA, Holden RM.   +6 more
europepmc   +1 more source