Results 21 to 30 of about 2,187,738 (295)

Environmental triggers of COPD symptoms: a case cross-over study [PDF]

BMJ Open Respiratory Research, 2017
IntroductionThis study investigated the hypothesis that common environmental chemical exposures with known irritant or sensitising properties trigger exacerbations for patients with chronic obstructive pulmonary disease (COPD).MethodsWe conducted a case cross-over study in 168 patients with COPD who were members of a disease management group in central
Richard Rosiello, David Kriebel, Rebecca Gore, Susan R. Sama, Rebecca DeVries   +4 more
openaire   +2 more sources

Cross-national analyses require additional controls to account for the non-independence of nations

Nature Communications, 2023
Cross-national analyses test hypotheses about the drivers of variation in national outcomes. However, since nations are connected in various ways, such as via spatial proximity and shared cultural ancestry, cross-national analyses often violate ...
Scott Claessens, Thanos Kyritsis, Quentin D. Atkinson   +2 more
doaj   +1 more source

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection

Pharmaceutics, 2022
Innovative cross-over study designs were explored in non-human primate (NHP) studies to determine the value of this approach for the evaluation of drug efficacy against tuberculosis (TB). Firstly, the pharmacokinetics (PK) of each of the drugs Isoniazid (
Laura Sibley, Andrew D. White, Charlotte Sarfas, Jennie Gullick, Fergus Gleeson, Faye Lanni, Simon Clark, Emma Rayner, Santiago Ferrer-Bazaga, Fatima Ortega-Muro, Laura Alameda, Joaquin Rullas, Veronica Sousa, Marisa Martinez, Inigo Angulo-Barturen, Adolfo Garcia, Juan José Vaquero, Henry E. Pertinez, Geraint Davies, Mike Dennis, Ann Williams, Sally Sharpe   +21 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Challenges faced and lessons learned A multi-component prospective memory training program for Malaysian older adults

Dementia & Neuropsychologia
The surrounding circumstances and environments of Malaysian older adults could make conducting interventions (mainly in terms of clinical or randomized controlled trials) a challenge.
Azin Farzin, Rahimah Ibrahim, Zainal Madon, Hamidon Basri   +3 more
doaj   +1 more source

Moving in the Dark: Enlightening the Spatial Population Ecology of European Cave Salamanders

Population Ecology, EarlyView.
We assessed individual interactions, movement ecology and activity patterns of a subterranean population of Speleomantes strinatii, applying spatial capture–recapture modeling to a photographic dataset of 104 individuals. ABSTRACT Space use and movement are fundamental aspects of organisms' ecology, mirroring individual fitness, behavior, and life ...
Giacomo Rosa, Andrea Costa, Sebastiano Salvidio   +2 more
wiley   +1 more source

Air pollution, including PM10, as a potential risk factor for the development of appendicitis in Korea: a case-crossover study

The Ewha Medical Journal
Objectives: Interest in the association between particulate air pollution and appendicitis risk has been increasing in recent years, and previous studies have suggested a link between particulate matter ≤10
Yongho Jee, Jin Hoon Nam, Jongmin Oh, Gyoung Tae Noh, Eunhee Ha, Ryung Ah Lee   +5 more
doaj   +1 more source

Bioavailability of n-3 fatty acids from n-3-enriched foods and fish oil with different oxidative quality in healthy human subjects: a randomised single-meal cross-over study

Journal of Nutritional Science, 2016
Regular consumption of long-chain n-3 fatty acids (LC n-3 FA) reduces postprandial triacylglycerolaemia. Functional foods and supplements are alternative sources of LC n-3 FA; however, emulsification technologies, food matrices and altered lipid ...
Inger Ottestad, Berit Nordvi, Gjermund Vogt, Marianne Holck, Bente Halvorsen, Kirsti W. Brønner, Kjetil Retterstøl, Kirsten B. Holven, Astrid Nilsson, Stine M. Ulven   +9 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source