Results 21 to 30 of about 2,115,171 (296)

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection

Pharmaceutics, 2022
Innovative cross-over study designs were explored in non-human primate (NHP) studies to determine the value of this approach for the evaluation of drug efficacy against tuberculosis (TB). Firstly, the pharmacokinetics (PK) of each of the drugs Isoniazid (
Laura Sibley, Andrew D. White, Charlotte Sarfas, Jennie Gullick, Fergus Gleeson, Faye Lanni, Simon Clark, Emma Rayner, Santiago Ferrer-Bazaga, Fatima Ortega-Muro, Laura Alameda, Joaquin Rullas, Veronica Sousa, Marisa Martinez, Inigo Angulo-Barturen, Adolfo Garcia, Juan José Vaquero, Henry E. Pertinez, Geraint Davies, Mike Dennis, Ann Williams, Sally Sharpe   +21 more
doaj   +1 more source

Challenges faced and lessons learned A multi-component prospective memory training program for Malaysian older adults

Dementia & Neuropsychologia
The surrounding circumstances and environments of Malaysian older adults could make conducting interventions (mainly in terms of clinical or randomized controlled trials) a challenge.
Azin Farzin, Rahimah Ibrahim, Zainal Madon, Hamidon Basri   +3 more
doaj   +1 more source

Air pollution, including PM10, as a potential risk factor for the development of appendicitis in Korea: a case-crossover study

The Ewha Medical Journal
Objectives: Interest in the association between particulate air pollution and appendicitis risk has been increasing in recent years, and previous studies have suggested a link between particulate matter ≤10
Yongho Jee, Jin Hoon Nam, Jongmin Oh, Gyoung Tae Noh, Eunhee Ha, Ryung Ah Lee   +5 more
doaj   +1 more source

Do ball-type attachment systems for overdenture result in better patient-satisfaction? A systematic review of randomized crossover clinical trial

Saudi Dental Journal, 2021
Objective: This review is to compare patient-satisfaction with ball-type overdenture attachment systems with others attachment systems. Material and methods: This study was registered in PROSPERO (CRD42018097234) and adheres the PRISMA guidelines ...
Cleber Davi Del Rei Daltro Rosa, Rafaella de Souza Leão, Cátia Maria Fonseca Guerra, Eduardo Piza Pellizzer, Bruno Gustavo da Silva Casado, Sandra Lúcia Dantas de Moraes   +5 more
doaj  

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

Population Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

Bioavailability of n-3 fatty acids from n-3-enriched foods and fish oil with different oxidative quality in healthy human subjects: a randomised single-meal cross-over study

Journal of Nutritional Science, 2016
Regular consumption of long-chain n-3 fatty acids (LC n-3 FA) reduces postprandial triacylglycerolaemia. Functional foods and supplements are alternative sources of LC n-3 FA; however, emulsification technologies, food matrices and altered lipid ...
Inger Ottestad, Berit Nordvi, Gjermund Vogt, Marianne Holck, Bente Halvorsen, Kirsti W. Brønner, Kjetil Retterstøl, Kirsten B. Holven, Astrid Nilsson, Stine M. Ulven   +9 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Population health differences in cross-border regions within the European Union and Schengen area: a protocol for a scoping review

BMJ Open, 2023
Introduction Along with European integration and the harmonisation of living conditions, improvements in health have been observed over the past decades. However, sociospatial inequalities within and across member states still exist today.
Viola Angelini, Tobias Vogt, Sophie Stroisch, Sebastian Schnettler   +3 more
doaj   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source