Results 61 to 70 of about 621,864 (351)

Characterising two-pathogen competition in spatially structured environments [PDF]

, 2014
Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the host immune system, the host life cycle, and the space structure of the ...
Colizza, Vittoria, Meloni, Sandro, Moreno, Yamir, Poletto, Chiara, Van Metre, Ashleigh, Vespignani, Alessandro   +5 more
core   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Vaccination against SARS-CoV-2 provides low-level cross-protection against common cold coronaviruses in mouse and non-human primate animal models

Journal of Virology
The common cold coronaviruses are a source of ongoing morbidity and mortality particularly among elderly and immunocompromised individuals. While cross-reactive immune responses against multiple coronaviruses have been described following severe acute ...
Maedeh Naghibosadat, George Giorgi Babuadze, Yanlong Pei, Jacklyn Hurst, Elsa Salvant, Kayla Gaete, Mia Biondi, Badru Moloo, Alyssa Goldstein, Stacey Avery, Kathleen Ma, Anna Pietraszek, Sarah K. Wootton, Assad Alhaboub, Benjamin Martin, Samira Mubareka, Juan Corredor, Azmiri Sultana, Adebayo Adeekoa, Patrick Budylowski, Mario Ostrowski, Jesse Chao, Eva Nagy, Robert Kozak   +23 more
doaj   +1 more source

Advances and Future Challenges in Recombinant Adenoviral Vectored H5N1 Influenza Vaccines

Viruses, 2012
The emergence of a highly pathogenic avian influenza virus H5N1 has increased the potential for a new pandemic to occur. This event highlights the necessity for developing a new generation of influenza vaccines to counteract influenza disease.
Jianfeng Zhang
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Human papillomavirus and HPV vaccines: a review [PDF]

, 2007
Cervical cancer, the most common cancer affecting women in developing countries, is caused by persistent infection with "high-risk" genotypes of human papillomaviruses (HPV). The most common oncogenic HPV genotypes are 16 and 18, causing approximately 70%
Castellsague, X., Claeys, P., Cutts, F. T., de Sanjose, S., Edmunds, W. J., Franceschi, S., Garnett, G., Goldenthal, K. L., Goldie, S., Harper, D. M., Markowitz, L.   +10 more
core   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Impact of viral drift on vaccination dynamics and patterns of seasonal influenza [PDF]

, 2013
BACKGROUND: Much research has been devoted to the determination of optimal vaccination strategies for seasonal influenza epidemics. However, less attention has been paid to whether this optimization can be achieved within the context of viral drift ...
Seyed M Moghadas, Yanyu Xiao
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source