Results 81 to 90 of about 621,864 (351)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology

Emerging Microbes and Infections, 2017
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has recently caused extensive outbreaks in Central and South America and the Caribbean.
Lalita Priyamvada, William Hudson, Rafi Ahmed, Jens Wrammert   +3 more
doaj   +1 more source

Non-lethal heat shock protects gnotobiotic Artemia franciscana larvae against virulent Vibrios [PDF]

, 2007
Brine shrimp Artemia were exposed under gnotobiotic conditions to a non-lethal heat shock (NLHS) from 28 to 32, 37 and 40°C. Different recovery periods (2, 6, 12 and 24 h) and different heat-exposure times (15, 30, 45 and 60 min) were tested. After these
Bossier, P., Sorgeloos, P., Van Damme, E.J.M., Yik Sung, Y.   +3 more
core  

Cross-protection and cross-neutralization capacity of ancestral and VOC-matched SARS-CoV-2 adenoviral vector-based vaccines [PDF]

, 2023
Sabrina E. Vinzón, María Verónica Lopez, Eduardo G. Cafferata, Ariadna S. Soto, Paula M. Berguer, Luciana Vázquez, Leonora Nusblat, Andrea Pontoriero, E.M. Belotti, Natalia R. Salvetti, Diego L. Viale, Ariel Esteban Vilardo, Martín Avaro, Estefanía Benedetti, Mara Russo, María Elena Dattero, Mauricio Carobene, Maximiliano Sánchez‐Lamas, Jimena Afonso, Mauro Heitrich, Alejandro E. Cristófalo, Lisandro H. Otero, Elsa Baumeister, Hugo H. Ortega, Alexis Edelstein, Osvaldo L. Podhajcer   +25 more
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sequential Immunizations with Influenza Neuraminidase Protein Followed by Peptide Nanoclusters Induce Heterologous Protection

Viruses
Enhancing cross-protections against diverse influenza viruses is desired for influenza vaccinations. Neuraminidase (NA)-specific antibody responses have been found to independently correlate with a broader influenza protection spectrum. Here, we report a
Wen-Wen Song, Mu-Yang Wan, Jia-Yue She, Shi-Long Zhao, De-Jian Liu, Hai-Yan Chang, Lei Deng   +6 more
doaj   +1 more source

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland [PDF]

, 2014
In Scotland, a national HPV immunisation programme began in 2008 for 12-13 year olds, with a catch-up campaign from 2008-2011 for those under the age of 18.
A Potts, AR Kreimer, B Baldur-Felskov, B Romanowski, C Robertson, CM Wheeler, D Baker, E Crowe, H Cubie, HL Bowyer, J Love, J Paavonen, JML Brotherton, JS Smith, K Cuschieri, K Cuschieri, K G J Pollock, K Kavanagh, K Kavanagh, K Kavanagh, K Sinka, L Henderson, LAV Marlow, M Cruickshank, M Donaghy, MC O’Leary, RS Bhopal, S Nicoll, SE Powell, T J Palmer, T Malagon, TG Hopkins   +31 more
core   +4 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Development and characterization of a human monoclonal antibody for prevention of HCV recurrence in liver transplant patients [PDF]

, 2017
More than 170 million people worldwide are chronically infected with hepatitis C virus (HCV) and are at risk of developing liver fibrosis, cirrhosis and hepatocellular carcinoma.
Ball, Jonathan, Desombere, Isabelle, Farhoudi Moghadam, Aliasghar, Johansson, Daniel X, Leroux-Roels, Geert, Mesalam, Ahmed Atef Ahmed Abouzeid, Meuleman, Philip, Persson, Mats, Urbanowicz, Richard, Van Houtte, Freya, Vercauteren, Koen, Verhoye, Lieven   +11 more
core   +1 more source

A cost effectiveness and capacity analysis for the introduction of universal rotavirus vaccination in Kenya : comparison between Rotarix and RotaTeq vaccines [PDF]

, 2012
Background Diarrhoea is an important cause of death in the developing world, and rotavirus is the single most important cause of diarrhoea associated mortality. Two vaccines (Rotarix and RotaTeq) are available to prevent rotavirus disease.
A Kerdpanich, Albert Jan van Hoek, Amina Ismail, B Girma, BA Lopman, CL Fischer Walker, D. James Nokes, David Mutonga, DE Atherly, DH Esposito, DJ Nokes, DJ Nokes, G Armah, J Nyangao, Jane Chuma, JE Tate, K Zaman, KJ Rothman, M Ombok, M Patel, Maarten Postma, MM Cortese, Mwanajuma Ngama, NM Kiulia, RE Black, S Flessa, S Madhi, Samuel Cheburet, T Ruuska, Tatu Kamau   +29 more
core   +3 more sources