Results 91 to 100 of about 621,864 (351)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evaluation of Different Machine Learning Approaches to Predict Antigenic Distance Among Newcastle Disease Virus (NDV) Strains

Viruses
Newcastle disease virus (NDV) continues to present a significant challenge for vaccination due to its rapid evolution and the emergence of new variants.
Giovanni Franzo, Alice Fusaro, Chantal J. Snoeck, Aleksandar Dodovski, Steven Van Borm, Mieke Steensels, Vasiliki Christodoulou, Iuliana Onita, Raluca Burlacu, Azucena Sánchez Sánchez, Ilya A. Chvala, Mia Kim Torchetti, Ismaila Shittu, Mayowa Olabode, Ambra Pastori, Alessia Schivo, Angela Salomoni, Silvia Maniero, Ilaria Zambon, Francesco Bonfante, Isabella Monne, Mattia Cecchinato, Alessio Bortolami   +22 more
doaj   +1 more source

Post-hoc analysis from phase III trials of human papillomavirus vaccines: considerations on impact on non-vaccine types

Expert Review of Vaccines, 2019
Background: Substantial heterogeneity has been reported in efficacy against high-grade cervical intraepithelial neoplasia (CIN) irrespective of HPV type in phase III results for bivalent and quadrivalent human papillomavirus virus (HPV) vaccines (AS04 ...
Martin Ryser, Valérie Berlaimont, Naveen Karkada, Attila Mihalyi, Rino Rappuoli, Robbert van der Most   +5 more
doaj   +1 more source

High Salt Cross-Protects Escherichia coli from Antibiotic Treatment through Increasing Efflux Pump Expression

mSphere, 2018
Environmental stresses often co-occur when bacteria encounter antibiotic treatment inside the human body. The cellular response to environmental stressors can alter the global gene expression pattern of bacteria.
Manlu Zhu, Xiongfeng Dai
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

Emerging Microbes and Infections
The H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like particle (VLP) vaccine based on the insect ...
Dexin Kong, Yanjuan He, Jiaxin Wang, Lanyan Chi, Xiang Ao, Hejia Ye, Weihong Qiu, Xiutong Zhu, Ming Liao, Huiying Fan   +9 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Vaccination against heartwater using in vitro attenuated Cowdria ruminantium organisms [PDF]

, 1993
Des passages successifs de Cowdria ruminantium (stock Sénégal) dans des cultures de cellules endothéliales ombilicales bovines ont produit une perte de virulence sans perte d'immunogénicité, comme il a été démontré antérieurement.
Gueye, Arona, Jongejan, Frans, Uilenberg, Gerrit, Vogel, S.W.   +3 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe [PDF]

, 2012
Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery1,2, spreading efficiently via low-dose fecal-oral transmission3,4. Historically, S.
A Mutreja, A Nastasi, A Saeed, A Stamatakis, AJ Drummond, Andrew Kitchen, D Cohen, D Genobile, DA Sack, Derek J Brown, Derek J Pickard, DK Karaolis, Dong Wook Kim, DR Zerbino, E Paradis, Edward C Holmes, F Yang, François-Xavier Weill, G Greub, G Morelli, GM Pupo, Gordon Dougan, H Li, H Li, H Vinh, H Vinh, H Vinh, HC Lewis, HJ Jeong, HL DuPont, J Parker, J Tang, J Winiecka-Krusnell, Jeremy J Farrar, JG Shepherd, John E Coia, Julian Parkhill, Jun Yu, Kathryn E Holt, KE Holt, KL Kotloff, LL Van de Verg, M Touchon, Nicholas R Thomson, PJ Sansonetti, R Ranjbar, RK Aziz, RW Kaminski, S Kurtz, Seon Young Choi, SR Harris, Stephen Baker, Su Hee Kim, T Shimada, Vartul Sangal, Wanderley D da Silveira   +55 more
core   +4 more sources