Results 1 to 10 of about 256,194 (269)

Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress

Acta Biochimica et Biophysica Sinica, 2023
Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens.
Liang Yuxiang, Wang Ying, Zhang Xiao, Jin Shanshan, Guo Yuqian, Yu Zhaowei, Xu Xinrui, Shuai Qizhi, Feng Zihan, Chen Binghong, Liang Ting, Ao Ruifang, Li Jianting, Zhang Juan, Cao Rui, Zhao Hong, Chen Zhaoyang, Liu Zhizhen, Xie Jun   +18 more
doaj   +1 more source

Use of the Fluorescent Dye Thioflavin T to Track Amyloid Structures in the Pathogenic Yeast Candida albicans

Bio-Protocol
The human pathogenic yeast Candida albicans can attach to epithelial cells or indwelling medical devices to form biofilms. These microbial communities are highly problematic in the clinic as they reduce both sensitivity to antifungal drugs and detection ...
Thierry Mourer, Christophe d'Enfert, Sophie Bachellier-Bassi   +2 more
doaj   +1 more source

Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?

Cells, 2017
Entamoeba histolytica is the causative agent of human amoebiasis; it affects 50 million people worldwide and causes approximately 100,000 deaths per year.
Erika Pineda, Doranda Perdomo
doaj   +1 more source

Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers

mBio, 2018
Life-threatening systemic infections often occur due to the translocation of pathogens across the gut barrier and into the bloodstream. While the microbial and host mechanisms permitting bacterial gut translocation are well characterized, these ...
Stefanie Allert, Toni M. Förster, Carl-Magnus Svensson, Jonathan P. Richardson, Tony Pawlik, Betty Hebecker, Sven Rudolphi, Marc Juraschitz, Martin Schaller, Mariana Blagojevic, Joachim Morschhäuser, Marc Thilo Figge, Ilse D. Jacobsen, Julian R. Naglik, Lydia Kasper, Selene Mogavero, Bernhard Hube   +16 more
doaj   +1 more source

Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses

Viruses, 2019
Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines.
Ga-Eun Lee, Eric Mauro, Vincent Parissi, Cha-Gyun Shin, Paul Lesbats   +4 more
doaj   +1 more source

An In Vitro A-431 Epithelial Cell Infection Model for Studying Fungal Pathogenicity and Immune Responses Associated With Vulvovaginal Candidiasis

Bio-Protocol
Vulvovaginal candidiasis (VVC), also known as vaginal thrush, is an infection of the vulvovaginal mucosa caused by fungi of the Candida genus. Particularly for patients suffering from recurrent infection, the disease has a significant impact on their ...
Victoria Groß, Kar Cheng, Beatriz Cristóvão, Ezgi Gürel, Maximilian Himmel, Candela Fernández-Fernández, Jördis Schuchardt, Axel Dietschmann, Dolly Montaño, Mark Gresnigt   +9 more
doaj   +1 more source

Lead exposure induces ferroptosis in ALS cell models by activating the MAPK/ERK signaling pathway

Ecotoxicology and Environmental Safety
Lead is a potent toxicant that exerts deleterious effects on multiple organ systems within the human body. Existing evidence suggests that lead exposure may contribute to the progression of amyotrophic lateral sclerosis (ALS).
Yi Gao, Bingxue Zheng, Xiaoxiao Peng, Nanxin Ma, Yan Qi, Xiaodie Lan, Ying Wang, Hongyan Zha, Chu Zhou, Fuying Liu, Qian Zhao, Hongyan Cao, Li Wang, Yulan Qiu, Jinping Zheng, Jian Guo   +15 more
doaj   +1 more source

Estimating the causal effects of exposure mixtures: a generalized propensity score method

BMC Medical Research Methodology
Background In environmental epidemiology and many other fields, estimating the causal effects of multiple concurrent exposures holds great promise for driving public health interventions and policy changes. Given the predominant reliance on observational
Qian Gao, Ting Li, Guiming Zhu, Juping Wang, Kexin Qiu, Liangpo Liu, Xiujuan Yang, Tong Wang   +7 more
doaj   +1 more source

Hourly ozone concentration estimation and its health impact study based on ensemble machine learning: A case study of Taiyuan City

环境与职业医学
BackgroundOzone (O3) is a major air pollutant. The existing monitoring system has uneven distribution of sites, insufficient coverage in underdeveloped areas, and low temporal resolution, making it difficult to obtain hourly data. This limits the dynamic
Rule DU, Xiaojuan YANG, Ruixia NIU, Yang XU, Guiming ZHU, Qian GAO, Tong WANG   +6 more
doaj   +1 more source

“Should I stay or should I go”—a kinase delays escape of Candida glabrata from macrophages

mBio
Candida glabrata is an opportunistic fungal pathogen that causes both superficial and systemic infections in humans, accounting for 15%–25% of invasive candidiasis cases. Macrophages play a crucial role in antifungal immunity by internalizing C. glabrata;
Theresa Lange, Colin Clairet, Luisa Fischer, Raghav Vij, Johannes Sonnberger, Julia Mantke, Nadja Jablonowski, Eric Seemann, Britta Qualmann, Christophe d’Enfert, Lydia Kasper, Bernhard Hube, Sascha Brunke   +12 more
doaj   +1 more source