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Virology, 1996 The pathogenicity of rotaviruses depends on multiple viral and host factors. In this review the evidence for the involvement of a number of viral genes in the ability to cause disease is presented. Different genes are of importance in different rotavirus-host systems: there is no single pathogenicity factor.
Burke, B, Desselberger, U
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Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
Cells, 2017 Entamoeba histolytica is the causative agent of human amoebiasis; it affects 50 million people worldwide and causes approximately 100,000 deaths per year.
Erika Pineda, Doranda Perdomo
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mBio, 2018 Life-threatening systemic infections often occur due to the translocation of pathogens across the gut barrier and into the bloodstream. While the microbial and host mechanisms permitting bacterial gut translocation are well characterized, these ...
Stefanie Allert +16 more
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Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses
Viruses, 2019 Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines.
Ga-Eun Lee +4 more
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Bio-ProtocolVulvovaginal candidiasis (VVC), also known as vaginal thrush, is an infection of the vulvovaginal mucosa caused by fungi of the Candida genus. Particularly for patients suffering from recurrent infection, the disease has a significant impact on their ...
Victoria Groß +9 more
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Lead exposure induces ferroptosis in ALS cell models by activating the MAPK/ERK signaling pathway
Ecotoxicology and Environmental SafetyLead is a potent toxicant that exerts deleterious effects on multiple organ systems within the human body. Existing evidence suggests that lead exposure may contribute to the progression of amyotrophic lateral sclerosis (ALS).
Yi Gao +15 more
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The pathogenicity of cytomegalovirus [PDF]
FEMS Microbiology Reviews, 1999 Human cytomegalovirus is ubiquitous, yet causes little illness in immunocompetent individuals. Disease is evident in immunodeficient groups such as neonates, transplant recipients and AIDS patients either following a primary infection or reactivation of a latent infection. Little is known of the mechanisms underlying the pathogenicity of the virus. The
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Estimating the causal effects of exposure mixtures: a generalized propensity score method
BMC Medical Research MethodologyBackground In environmental epidemiology and many other fields, estimating the causal effects of multiple concurrent exposures holds great promise for driving public health interventions and policy changes. Given the predominant reliance on observational
Qian Gao +7 more
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环境与职业医学BackgroundOzone (O3) is a major air pollutant. The existing monitoring system has uneven distribution of sites, insufficient coverage in underdeveloped areas, and low temporal resolution, making it difficult to obtain hourly data. This limits the dynamic
Rule DU +6 more
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“Should I stay or should I go”—a kinase delays escape of Candida glabrata from macrophages
mBioCandida glabrata is an opportunistic fungal pathogen that causes both superficial and systemic infections in humans, accounting for 15%–25% of invasive candidiasis cases. Macrophages play a crucial role in antifungal immunity by internalizing C. glabrata;
Theresa Lange +12 more
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