Results 41 to 50 of about 460,180 (313)

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3 - Implications for the evolution of staphylococcal pathogenicity islands [PDF]

, 2002
We describe the complete sequence of the 15.9-kb staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K, and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading
Kapur, Vivek, McCormick, John K., Orwin, Paul M., Paustian, Michael L., Schlievert, Patrick M., Yarwood, Jeremy M.   +5 more
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Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Shining a light on Candida-induced epithelial damage with a luciferase reporter

mSphere
Host cell damage is a key parameter for research in infection biology, drug testing, and substance safety screening. In this study, we introduce a luciferase reporter system as a new and reliable assay to measure cell damage and validate it with the ...
Millen Tesfamariam, Raghav Vij, Verena Trümper, Bernhard Hube, Sascha Brunke   +4 more
doaj   +1 more source

Genetic screening for hypertension and COVID-19 reveals functional variation of SPEG potentially associated with severe COVID-19 in women

Frontiers in Genetics, 2023
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to more than 6.4 million deaths worldwide.
Yu-Si Luo, Yu-Si Luo, Xiang-Chun Shen, Xiang-Chun Shen, Wei Li, Guo-Feng Wu, Xiao-Meng Yang, Ming-Yang Guo, Fang Chen, Hu-Yan Shen, Ping-Ping Zhang, Han Gao, Ying Nie, Jia-Hong Wu, Rong Mou, Ke Zhang, Ke Zhang, Zhong-Shan Cheng   +17 more
doaj   +1 more source

Pathogen Sensors [PDF]

Sensors, 2009
The development of sensors for detecting foodborne pathogens has been motivated by the need to produce safe foods and to provide better healthcare. However, in the more recent times, these needs have been expanded to encompass issues relating to biosecurity, detection of plant and soil pathogens, microbial communities, and the environment. The range of
openaire   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Equal Neutralizing Effectiveness of BNT162b2, ChAdOx1 nCoV-19, and Sputnik V Vaccines in the Palestinian Population

Vaccines
Since the beginning of the COVID-19 pandemic, different viral vector-based and mRNA vaccines directed against the SARS-CoV-2 “S” spike glycoprotein have been developed and have shown a good profile in terms of safety and efficacy.
Alexia Damour, Muriel Faure, Nicolas Landrein, Jessica Ragues, Narda Ardah, Haneen Dhaidel, Marie-Edith Lafon, Harald Wodrich, Walid Basha   +8 more
doaj   +1 more source

Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress

Acta Biochimica et Biophysica Sinica, 2023
Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens.
Liang Yuxiang, Wang Ying, Zhang Xiao, Jin Shanshan, Guo Yuqian, Yu Zhaowei, Xu Xinrui, Shuai Qizhi, Feng Zihan, Chen Binghong, Liang Ting, Ao Ruifang, Li Jianting, Zhang Juan, Cao Rui, Zhao Hong, Chen Zhaoyang, Liu Zhizhen, Xie Jun   +18 more
doaj   +1 more source

Pathogenicity in Verticillium on strawberry plants [PDF]

, 2008
In the most common strawberry cv. ’Elsanta’, Verticillium infection can lead to rapid wilt and even death of plants. It is known, that a dead plant can be located directly beside vital ones.
Golldack, J., Lentzsch, P., Schubert, P., Schwärzel, H.   +3 more
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