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The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein—TbBILBO1

open access: yesCells, 2016
Sub-species of Trypanosoma brucei are the causal agents of human African sleeping sickness and Nagana in domesticated livestock. These pathogens have developed an organelle-like compartment called the flagellar pocket (FP).
Doranda Perdomo   +2 more
doaj   +1 more source

Targeting Antibiotic Tolerance, Pathogen by Pathogen [PDF]

open access: yesCell, 2018
Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathogen approach to illustrate the clinical significance of antibiotic tolerance and discuss how the ...
Meylan, Sylvain   +2 more
openaire   +4 more sources

A multigene family encoding surface glycoproteins in Trypanosoma congolense

open access: yesMicrobial Cell, 2017
Trypanosoma congolense, the causative agent of the most important livestock disease in Africa, expresses specific surface proteins involved in its parasitic lifestyle. Unfortunately, the complete repertoire of such molecules is far from being deciphered.
Magali Thonnus   +2 more
doaj   +1 more source

Autophagy vitalizes the pathogenicity of pathogenic fungi [PDF]

open access: yesAutophagy, 2012
Plant pathogenic fungi utilize a series of complex infection structures, in particular the appressorium, to gain entry to and colonize plant tissue. As a consequence of the accumulation of huge quantities of glycerol in the cell the appressorium generates immense intracellular turgor pressure allowing the penetration peg of the appressorium to ...
Xiao-Hong, Liu   +5 more
openaire   +2 more sources

The Fungal Pathogen Candida glabrata Does Not Depend on Surface Ferric Reductases for Iron Acquisition

open access: yesFrontiers in Microbiology, 2017
Iron acquisition is a crucial virulence determinant for many bacteria and fungi, including the opportunistic fungal pathogens Candida albicans and C. glabrata. While the diverse strategies used by C.
Franziska Gerwien   +7 more
doaj   +1 more source

Transient Mitochondria Dysfunction Confers Fungal Cross-Resistance against Phagocytic Killing and Fluconazole

open access: yesmBio, 2021
Candida glabrataCandida ...
Sofía Siscar-Lewin   +5 more
doaj   +1 more source

From intestinal colonization to systemic infections: Candida albicans translocation and dissemination

open access: yesGut Microbes, 2022
Candida species are the most prevalent cause of invasive fungal infections, of which Candida albicans is the most common. Translocation across the epithelial barrier into the bloodstream by intestinal-colonizing C.
Jakob L. Sprague   +2 more
doaj   +1 more source

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration

open access: yesRetrovirology, 2017
Background Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodeling has been reported to affect ...
Julien Matysiak   +13 more
doaj   +1 more source

Retroviral integration site selection: a running Gag?

open access: yesMicrobial Cell, 2018
The ability of retroviruses to integrate their genomes into host chromatin is a key step for the completion of their replication cycle. Selection of a suitable chromosomal integration site has been described as a hierarchical mechanism involving both ...
Paul Lesbats, Vincent Parissi
doaj   +1 more source

Viral pathogens [PDF]

open access: yesHaemophilia, 2010
Summary.  Despite continuous improvement in safety and purity of blood products for individuals with haemophilia, transmissible agents continue to affect individuals with haemophilia. This chapter addresses three viral pathogens with significant clinical impact: HIV, hepatitis C and parvovirus B19.
M V, Ragni, K E, Sherman, J A, Jordan
openaire   +2 more sources

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