The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins [PDF]
Cell Death DiscoveryThe common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells counteract pore-forming toxins by Ca2+-dependent mechanisms, such as microvesicle shedding and annexin recruitment to resist ...
Roshan Thapa +5 more
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Host targets of candidalysin. [PDF]
PLoS PathogensCandida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C.
Jianfeng Lin, Scott G Filler
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Candidalysin at the epithelial-systemic interface: mechanistic evidence, critical-care relevance, and translational opportunities in invasive candidiasis [PDF]
Frontiers in Cellular and Infection MicrobiologyInvasive candidiasis remains a stubborn source of morbidity and mortality in critically ill and immunocompromised patients. One reason progress has been slow is that the route from epithelial colonization to bloodstream or deep-organ infection is still ...
Yidan Fu, Xiaonan Li, Xianyao Wan
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Variations in candidalysin amino acid sequence influence toxicity and host responses.
MBioCandida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host ...
Sejeong Lee +2 more
exaly +4 more sources
Discovery of the High-Affinity Aptamer for Candidalysin Using a Dual-Mode Colorimetric–SERS Platform [PDF]
BiosensorsCandida albicans poses significant health risks through its virulent peptide toxin Candidalysin. As no existing therapeutics specifically target this toxin, developing high-affinity aptamers for its efficient and safe removal is urgently needed.
Le Qiang, Yu Zhang, Lin Han
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Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells [PDF]
Cells, 2020 Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to ...
Jonathan P Richardson +2 more
exaly +4 more sources
Hemolytic Activity of Vaginal Candida albicans Isolates and Antifungal Effects of Quinalizarin with Hemolysis Modulation [PDF]
PathogensThis study evaluated the hemolytic activity of Candida albicans isolates from the female reproductive tract and investigated the in vitro effects of quinalizarin on fungal growth, hemolysis, and ECE1 expression. Ninety-four clinical C.
Monika Janeczko, Elżbieta Kochanowicz
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Phenotypic and genotypic analysis of Candida albicans vaginal isolates reveals that ECE1 expression underpins pathogenicity [PDF]
Infection and ImmunityCandida albicans is the leading cause of vulvovaginal candidiasis (VVC), yet the extent to which strain-level variation influences pathogenic mechanisms remains unclear.
Amirhossein Davari +15 more
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Candidalysin biology and activation of host cells [PDF]
mBioCandida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C.
Léa Lortal +8 more
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Detection of serum anti-candidalysin IgG by indirect ELISA: a novel auxiliary tool for diagnosing invasive candidiasis in a preliminary pediatric study [PDF]
Microbiology SpectrumInvasive candidiasis (IC) is the most common fungal infection in clinical settings, yet early diagnosis remains challenging. Candidalysin, a key virulence factor in invasive infections, exhibits site-specific pathogenicity.
Ting Luo +12 more
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