Candidalysin biology and activation of host cells [PDF]
MBioCandida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C.
Jonathan Richardson +2 more
exaly +8 more sources
Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model [PDF]
ToxinsCandida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract of healthy humans. Under certain conditions, it can become invasive and cause life-threatening systemic infections.
Moran Morelli
exaly +6 more sources
Variations in candidalysin amino acid sequence influence toxicity and host responses [PDF]
MBioCandida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host ...
Sejeong Lee +2 more
exaly +9 more sources
Host targets of candidalysin. [PDF]
PLoS PathogensCandida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C.
Jianfeng Lin, Scott G Filler
doaj +6 more sources
The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins [PDF]
Cell Death DiscoveryThe common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells counteract pore-forming toxins by Ca2+-dependent mechanisms, such as microvesicle shedding and annexin recruitment to resist ...
Roshan Thapa +5 more
doaj +3 more sources
Discovery of the High-Affinity Aptamer for Candidalysin Using a Dual-Mode Colorimetric–SERS Platform [PDF]
BiosensorsCandida albicans poses significant health risks through its virulent peptide toxin Candidalysin. As no existing therapeutics specifically target this toxin, developing high-affinity aptamers for its efficient and safe removal is urgently needed.
Yige Sun +8 more
doaj +2 more sources
Hemolytic Activity of Vaginal Candida albicans Isolates and Antifungal Effects of Quinalizarin with Hemolysis Modulation [PDF]
PathogensThis study evaluated the hemolytic activity of Candida albicans isolates from the female reproductive tract and investigated the in vitro effects of quinalizarin on fungal growth, hemolysis, and ECE1 expression. Ninety-four clinical C.
Monika Janeczko, Elżbieta Kochanowicz
doaj +2 more sources
Detection of serum anti-candidalysin IgG by indirect ELISA: a novel auxiliary tool for diagnosing invasive candidiasis in a preliminary pediatric study [PDF]
Microbiology SpectrumInvasive candidiasis (IC) is the most common fungal infection in clinical settings, yet early diagnosis remains challenging. Candidalysin, a key virulence factor in invasive infections, exhibits site-specific pathogenicity.
Ting Luo +12 more
doaj +2 more sources
Candida albicans-induced ubiquitination of EGFR reveals novel host–fungal interaction pathways [PDF]
mBioCandida albicans causes severe mucosal and systemic infections, with hypha formation playing a key role in its virulence. Hyphal invasion via endocytosis is mediated predominantly through interactions between Als3p and the epidermal growth factor ...
Léa Lortal +12 more
doaj +2 more sources
The combinatorial action of hyphal growth and candidalysin is critical for promoting Candida albicans oropharyngeal infection [PDF]
mBioCandida albicans is one of the most common fungal pathogens, yet much remains unknown about how its virulence factors cooperate to promote pathogenicity. To investigate this, CRISPR-Cas9 technology was used to create a panel of 19 single, double, triple,
Olivia K. A. Paulin +13 more
doaj +2 more sources