Candidalysin biology and activation of host cells [PDF]
mBioCandida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C.
Léa Lortal +8 more
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Host targets of candidalysin. [PDF]
PLoS PathogensCandida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C.
Jianfeng Lin, Scott G Filler
doaj +8 more sources
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor [PDF]
Nature Communications, 2019 Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Jemima Ho +2 more
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Variations in candidalysin amino acid sequence influence toxicity and host responses [PDF]
MBioCandida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host ...
Sejeong Lee +2 more
exaly +9 more sources
Global fungal-host interactome mapping identifies host targets of candidalysin [PDF]
Nature CommunicationsCandidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped.
Ning-Ning Liu, Xiuli Wang, Lei Pan
exaly +5 more sources
Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model [PDF]
ToxinsCandida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract of healthy humans. Under certain conditions, it can become invasive and cause life-threatening systemic infections.
Moran Morelli
exaly +6 more sources
Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins [PDF]
mBio, 2022 Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems.
Jonathan P. Richardson +18 more
doaj +9 more sources
Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses [PDF]
Infection and ImmunityExtracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication.
Sejeong Lee +12 more
doaj +6 more sources
The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins [PDF]
Cell Death DiscoveryThe common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells counteract pore-forming toxins by Ca2+-dependent mechanisms, such as microvesicle shedding and annexin recruitment to resist ...
Roshan Thapa +5 more
doaj +3 more sources
EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway [PDF]
VirulenceCandida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson +6 more
doaj +6 more sources