Results 41 to 50 of about 1,341 (134)
Candidalysin is required for neutrophil recruitment and virulence during systemic Candida albicans infection [PDF]
, 2019 Background Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis.
Murdoch, C. +27 more
core +1 more source
Fungal Toxins and Host Immune Responses
Frontiers in Microbiology, 2021 Fungi are ubiquitous organisms that thrive in diverse natural environments including soils, plants, animals, and the human body. In response to warmth, humidity, and moisture, certain fungi which grow on crops and harvested foodstuffs can produce ...
Rhys Brown +3 more
doaj +1 more source
The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease.
, 2020 BACKGROUND & AIMS: Alcohol-associated liver disease is a leading indication for liver transplantation and a leading cause of mortality. Alterations to the gut microbiota contribute to the pathogenesis of alcohol-associated liver disease.
Tu, Xin M +16 more
core +1 more source
Candidalysin secretion is correlated with IL-1β release and damage.
, 2021 HiBiT-tagged candidalysin secretion (Fig 6H) was plotted against (A) IL-1β release (Fig 6F) and (B) LDH levels (Fig 6G). Linear regression analysis was conducted and r2 values calculated. (TIF)
Andrew C. Dixson (11419367) +16 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 The mucosal surfaces of the human body are challenged by millions of microbes on a daily basis. Co-evolution with these microbes has led to the development of plastic mechanisms in both host and microorganisms that regulate the balance between preserving
Aize Pellon +2 more
doaj +1 more source
, 2021 (A) In silico modeling of candidalysin from both SC5314 and 529L reveal dihelical peptides with relatively conserved structure. (B) Sulforhodamine B (SRB) loaded lipid vesicles were treated with WT and VAR candidalysin for 1 h and fluorescence intensity (
Andrew C. Dixson (11419367) +16 more
core +1 more source
PLoS Pathogens, 2021 Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide.
Junyan Liu +16 more
doaj +1 more source
Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances
MedComm, Volume 7, Issue 9, September 2026.Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait +5 more
wiley +1 more source
Variant ECE1 is associated with reduced candidalysin secretion.
, 2021 (A) Schematic depicting C-terminal candidalysin HiBiT tag within the ECE1 open reading frame and general assay function. (B) Strains GP1 (untagged, open bars) or WOHBT (HiBiT tagged, closed bars) were grown in RPMI-1640 or YNB medium for 16 h ...
Andrew C. Dixson (11419367) +16 more
core +1 more source
mBio, 2018 Life-threatening systemic infections often occur due to the translocation of pathogens across the gut barrier and into the bloodstream. While the microbial and host mechanisms permitting bacterial gut translocation are well characterized, these ...
Stefanie Allert +16 more
doaj +1 more source