Results 41 to 50 of about 1,214 (146)

Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences

Nature Microbiology
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candidalysin and seven non-candidalysin Ece1 peptides (NCEPs), and is found to be conserved in clinical isolates. Here we
Müller, Rita, König, Annika, Groth, Sabrina, Zarnowski, Robert, Visser, Corissa, Handrianz, Tom, Maufrais, Corinne, Krüger, Thomas, Himmel, Maximilian, Lee, Sejeong, Priest, Emily, Yildirim, Deniz, Richardson, Jonathan, Blango, Matthew, Bougnoux, Marie-Elisabeth, Kniemeyer, Olaf, D’enfert, Christophe, Brakhage, Axel, Andes, David, Trümper, Verena, Nehls, Christian, Kasper, Lydia, Mogavero, Selene, Gutsmann, Thomas, Naglik, Julian, Allert, Stefanie, Hube, Bernhard   +26 more
openaire   +5 more sources

Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice [PDF]

Virulence
Vulvovaginal candidiasis (VVC) is a prevalent fungal infection primarily caused by the opportunistic pathogen Candida albicans. Among women affected by VVC, up to 8% experience more than four episodes per year, regarded as recurrent vulvovaginal ...
Julie Auffray, Nicolas Biteau, Anne Cayrel, Denis Dacheux, Hassana Hsein, Pierre Tchoreloff, Thierry Noel   +6 more
doaj   +2 more sources

PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape. [PDF]

PLoS ONE
The fundamental molecules of life are polymers. Prominent examples include nucleic acids and proteins, both of which exhibit a large array of mechanical properties and three-dimensional shapes. The bending rigidity of individual polymers is quantified by
Elizabeth A Conley, Creighton M Lisowski, Katherine G Schaefer, Harrison C Davison, Julie E Baguio, Ioan Kosztin, Gavin M King   +6 more
doaj   +2 more sources

Geniposide attenuates astrocyte pyroptosis in depression via long non‐coding RNA Six3os1‐mediated regulation of the miR‐511‐3p/COL9A3 axis and MAPK/NLRP3 signaling [PDF]

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Geniposide ameliorates depressive‐like behaviors in CUMS mice through the lncRNA Six3os1/miR‐511‐3p/COL9A3 axis and MAPK/NLRP3 signaling pathway. Abstract Depression involves multifaceted molecular pathways, with astrocyte pyroptosis emerging as a critical contributor to neuroinflammation.
Tianyu Zou, Cheng Mei, Xiaoyu Liang, Xiaolong Shang, Guoxiang Duan   +4 more
wiley   +2 more sources

The pathogenicity and future treatment strategies of Candida albicans [PDF]

Frontiers in Cellular and Infection Microbiology
Candida albicans (C. albicans) is a major pathogenic fungus that severely impacts on human health. This review systematically elaborates on the key pathogenic processes of C.
Jiadi Wu, Jiadi Wu, Chenyang Jiang, Hui Wang, Tongbin Chen, Xi Chen, Wenyue Da   +6 more
doaj   +2 more sources

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes [PDF]

Nature Communications, 2018
Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging
Lydia Kasper, Annika König, Paul-Albert Koenig, Mark S. Gresnigt, Johannes Westman, Rebecca A. Drummond, Michail S. Lionakis, Olaf Groß, Jürgen Ruland, Julian R. Naglik, Bernhard Hube   +10 more
doaj   +2 more sources

Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis [PDF]

PLOS Pathogens
Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces. While efforts have been devoted to identifying microbial factors that modulate C.
Kuo-Yao Tseng, Yu-Tsung Huang, Yu-Ting Huang, Yu-Ting Su, An-Ni Wang, Wen-Yen Weng, Cai-Ling Ke, Yu-Chiao Yeh, Jhih-Jie Wang, Shin-Hei Du, Zi-Qi Gu, Wei-Lin Chen, Ching-Hsuan Lin, Yu-Huan Tsai   +13 more
openaire   +3 more sources

Beyond colonization: Candida albicans exhibits substantial pathogenic potential in cystic fibrosis environments [PDF]

npj Biofilms and Microbiomes
Cystic fibrosis (CF) sputum represents a highly permissive niche for microbial colonization, yet the contribution of Candida albicans to disease progression remains insufficiently investigated despite its frequent detection in CF airways. We hypothesized
Natasa Radakovic, Nikola Plackic, Jelena Djuris, Joachim Morschhäuser, Aleksandar Sovtic, Mihail Basa, Predrag Minic, Fabio Zobi, Aleksandar Pavic   +8 more
doaj   +2 more sources

EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway [PDF]

Virulence
Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson, Aize Pellon, Nicole O. Ponde, Olivia Hepworth, Lydia F. Daniels Gatward, Julian R. Naglik, David L. Moyes   +6 more
doaj   +2 more sources

Essential role of hepcidin in host resistance to disseminated candidiasis [PDF]

Cell Reports
Summary: Candida albicans is a leading cause of life-threatening invasive infection despite antifungal therapy. Patients with chronic liver disease are at increased risk of candidemia, but the mechanisms underlying this susceptibility are incompletely ...
Tanmay Arekar, Divya Katikaneni, Sadat Kasem, Dhruv Desai, Thrisha Acharya, Augustina Cole, Nazli Khodayari, Sophie Vaulont, Bernhard Hube, Elizabeta Nemeth, Alexander Drakesmith, Michail S. Lionakis, Borna Mehrad, Yogesh Scindia   +13 more
doaj   +2 more sources