A New Phenotype in Candida-Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis- Associated Strains [PDF]
, 2023 Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality of life. Although Candida albicans is a common commensal, it is unknown if VVC results from a switch from a commensal to ...
Andrea Ardizzoni +19 more
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Candidalysin sets off the innate alarm [PDF]
Science Immunology, 2017 Candidalysin-induced epithelial cell damage promotes expansion of innate TCRαβ + cells during oropharyngeal candidiasis. See the related research article by Verma et al .
Xin Li, Irina Leonardi, Iliyan D. Iliev
openaire +2 more sources
Cell Reports, 2023 Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and
Yifan Wu +19 more
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Candida albicans and candidalysin in inflammatory disorders and cancer [PDF]
Immunology, 2020 SummaryAs our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C.
Jemima Ho +5 more
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Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.
PLoS Pathogens, 2021 During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
Marc Swidergall +10 more
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The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease [PDF]
Journal of Hepatology, 2020 Alcohol-associated liver disease is a leading indication for liver transplantation and a leading cause of mortality. Alterations to the gut microbiota contribute to the pathogenesis of alcohol-associated liver disease. Patients with alcohol-associated liver disease have increased proportions of Candida spp.
Huikuan Chu +16 more
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Candida Albicans Elicits Protective Allergic Responses Via Platelet Mediated T helper 2 and T helper 17 Cell Polarization [PDF]
, 2021 Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly understood.
Bimler, Lynn +17 more
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Geniposide attenuates astrocyte pyroptosis in depression via long non-coding RNA Six3os1-mediated regulation of the miR-511-3p/COL9A3 axis and MAPK/NLRP3 signaling. [PDF]
J Cell Commun SignalGeniposide ameliorates depressive‐like behaviors in CUMS mice through the lncRNA Six3os1/miR‐511‐3p/COL9A3 axis and MAPK/NLRP3 signaling pathway. Abstract Depression involves multifaceted molecular pathways, with astrocyte pyroptosis emerging as a critical contributor to neuroinflammation.
Zou T, Mei C, Liang X, Shang X, Duan G.
europepmc +2 more sources
EMBO reports, 2023 AbstractThe peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET‐like structures (NLS), which are more compact and less fibrous than canonical NETs.
Lucas Unger +12 more
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A tale of two yeasts : Saccharomyces cerevisiae as a therapeutic against candidiasis [PDF]
, 2016 Funding DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z), the MRC and University of ...
Wilson, Duncan
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