Results 1 to 10 of about 181,321 (160)
Pharmacokinetics of Toxin-Derived Peptide Drugs [PDF]
Toxins, 2018 Toxins and venoms produced by different organisms contain peptides that have evolved to have highly selective and potent pharmacological effects on specific targets for protection and predation.
David Stepensky
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Water Thermodynamics of Peptide Toxin Binding Sites on Ion Channels [PDF]
Toxins, 2020 Peptide toxins isolated from venomous creatures, long prized as research tools due to their innate potency for ion channels, are emerging as drugs as well.
Binita Shah +3 more
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Antibacterial and Anti-Inflammatory Effects of Novel Peptide Toxin from the Spider Pardosa astrigera [PDF]
Antibiotics, 2020 The prevalence of antibiotic-resistant bacteria has become an immediate threat to public health. Antimicrobial peptides are attracting attention as a new source of antibiotics due to their ability to prevent drug-resistances with fewer side effects ...
Min Kyoung Shin +8 more
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Cell ReportsSummary: Some microbial toxins also target the producer species itself, necessitating a means of self-protection. The M2 double-stranded RNA (dsRNA) killer virus in Saccharomyces cerevisiae contains a single open reading frame (ORF) encoding both the ...
Rianne C. Prins, Sonja Billerbeck
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Paulistine--The Functional Duality of a Wasp Venom Peptide Toxin. [PDF]
Toxins (Basel), 2016 It has been reported that Paulistine in the venom of the wasp Polybia paulista co-exists as two different forms: an oxidized form presenting a compact structure due to the presence of a disulfide bridge, which causes inflammation through an apparent interaction with receptors in the 5-lipoxygenase pathway, and a naturally reduced form (without the ...
Arcuri HA +6 more
europepmc +7 more sources
PhcrTx2, a New Crab-Paralyzing Peptide Toxin from the Sea Anemone Phymanthus crucifer [PDF]
Toxins, 2018 Sea anemones produce proteinaceous toxins for predation and defense, including peptide toxins that act on a large variety of ion channels of pharmacological and biomedical interest. Phymanthus crucifer is commonly found in the Caribbean Sea; however, the
Armando Alexei Rodríguez +12 more
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Candidalysin is a fungal peptide toxin critical for mucosal infection [PDF]
Nature, 2016 David L Moyes +2 more
exaly +2 more sources
Mycoplasma pneumoniae CARDS toxin elicits a functional IgE response in Balb/c mice. [PDF]
PLoS ONE, 2017 Mycoplasma pneumoniae is strongly associated with new onset asthma and asthma exacerbations. Until recently, the molecular mechanisms utilized by M. pneumoniae to influence asthma symptoms were unknown.
Jorge L Medina +3 more
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Toxins, 2021 The voltage-gated sodium channel NaV1.7 is an important target for drug development due to its role in pain perception. Recombinant expression of full-length channels and their use for biophysical characterization of interactions with potential drug ...
Ryan V. Schroder +4 more
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Pharmaceuticals, 2023 Ischemia–reperfusion injury (IRI) is a common phenomenon that develops both from natural causes and during major operations. Many intracellular processes mediated by calcium ions are involved in the development of IRI. Currently, chemical calcium channel
Elena Iurova +8 more
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