Results 11 to 20 of about 793,047 (255)

Candidalysin is a fungal peptide toxin critical for mucosal infection [PDF]

Nature, 2016
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses.
Thomas Gutsmann, Selvam Thavaraj, Duncan Wilson   +2 more
exaly   +4 more sources

Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli [PDF]

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O'Reilly, A.O., O’Reilly, A.O., Wallace, B.A., Cole, A.R., Lopes, J.L.S.   +7 more
core   +1 more source

A novel Kv1.1 potassium channel blocking toxin from the venom of Palamneus gravimanus (Indian black scorpion)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
A peptide toxin was isolated from the venom of Palamneus gravimanus, the Indian black scorpion, to block human Kv1.1 channels expressed in Xenopus laevis oocytes.
S. S. More, K. K. Mirajkar, J. R. Gadag, K. S. Menon, M. K. Mathew   +4 more
doaj   +1 more source

Identification of Novel Toxin Genes from the Stinging Nettle Caterpillar Parasa lepida (Cramer, 1799): Insights into the Evolution of Lepidoptera Toxins

Insects, 2021
Many animal species can produce venom for defense, predation, and competition. The venom usually contains diverse peptide and protein toxins, including neurotoxins, proteolytic enzymes, protease inhibitors, and allergens.
Natrada Mitpuangchon, Kwan Nualcharoen, Singtoe Boonrotpong, Patamarerk Engsontia   +3 more
doaj   +1 more source

Constitutive expression of Vr-ERE gene in transformed grapevines confers enhanced resistance to eutypine, a toxin from Eutypa lata [PDF]

, 2003
Eutypine (4-hydroxy-3-[3-methyl-3-butene-1-ynyl] benzaldehyde) is a toxin produced by Eutypa lata , the causal agent of eutypa dieback of grapevines.
Bouquet, Alain, Dalmayrac, Sylvie, Roustan, J.P., Legrand, Valérie, Dalmayrac, S., Alain Bouquet, Mondher Bouzayen, Sylvie Dalmayrac, Legrand, V., Bouzayen, M., Alain Latché, Bouzayen, Mondher, Roustan, Jean-Paul, Jean Fallot, Latché, Alain, Torregrosa, Laurent, Pech, Jean-Claude, Laurent Torregrosa, Pech, J.C., Fallot, Jean, Valérie Legrand, Jean-Claude Pech, Jean-Paul Roustan, Bouquet, A.   +23 more
core   +1 more source

Cloning and Characterization of a Cyclic Peptide Synthetase Gene from Alternaria alternata Apple Pathotype Whose Product Is Involved in AM-Toxin Synthesis and Pathogenicity

Molecular Plant-Microbe Interactions, 2000
Alternaria alternata apple pathotype causes Alternaria blotch of susceptible apple cultivars through the production of a cyclic peptide host-specific toxin, AM-toxin.
R. D. Johnson, L. Johnson, Y. Itoh, M. Kodama, H. Otani, K. Kohmoto   +5 more
doaj   +1 more source

Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer [PDF]

, 2006
Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple ...
Jennings, Keith R., Scrivens, JH, Williams, Jonathan P., Scrivens, James H., Williams, JP, Roberts, LM, Marsden, Brian D., Smith, Daniel C., Marsden, BD, Smith, DC, Roberts, Lynne M., Scrivens, James, Green, BN, Green, Brian N., Roberts, L. M. (Lynne M.), Jennings, KR   +15 more
core   +1 more source

High yield production and refolding of the double-knot toxin, an activator of TRPV1 channels. [PDF]

PLoS ONE, 2012
A unique peptide toxin, named double-knot toxin (DkTx), was recently purified from the venom of the tarantula Ornithoctonus huwena and was found to stably activate TRPV1 channels by targeting the outer pore domain.
Chanhyung Bae, Jeet Kalia, Inhye Song, JeongHeon Yu, Ha Hyung Kim, Kenton J Swartz, Jae Il Kim   +6 more
doaj   +1 more source

Characterization and evaluation of the enzymatic activity of tetanus toxin submitted to cobalt-60 gamma radiation [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination.
Giselle Pacifico Sartori, Andréa da Costa, Fernanda Lúcio dos Santos Macarini, Douglas Oscar Ceolin Mariano, Daniel Carvalho Pimenta, Patrick Jack Spencer, Luiz Henrique da Silva Nali, Andrés Jimenez Galisteo Jr.   +7 more
doaj   +1 more source

Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]

, 2012
Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050), J Michael Lord, Roberts Lynne M., Spooner, Robert A., Hampton Randolph Y., Lord J. Michael, Robert A. Spooner (150027), Spooner Robert A., Lord, J. Michael, Shuyu Li (18735), Roberts, Lynne M., Randolph Y Hampton, Lynne M Roberts, Shuyu Li, Lord, Mike, J. Michael Lord (150042), Li, Shuyu, Roberts, L. M. (Lynne M.), Robert A Spooner, Randolph Y. Hampton (150034), Li Shuyu, Hampton, Randolph Y.   +21 more
core   +2 more sources