Results 41 to 50 of about 260,045 (204)

Purification and Characterization of JZTx-14, a Potent Antagonist of Mammalian and Prokaryotic Voltage-Gated Sodium Channels

Toxins, 2018
Exploring the interaction of ligands with voltage-gated sodium channels (NaVs) has advanced our understanding of their pharmacology. Herein, we report the purification and characterization of a novel non-selective mammalian and bacterial NaVs toxin, JZTx-
Jie Zhang, Dongfang Tang, Shuangyu Liu, Haoliang Hu, Songping Liang, Cheng Tang, Zhonghua Liu   +6 more
doaj   +1 more source

Binding of κ-Conotoxin-PVIIA to Open and Closed Shaker K-Channels Are Differentially Affected by the Ionic Strength

Marine Drugs, 2020
κ-Conotoxin-PVIIA (κ-PVIIA) is a potassium-channel blocking peptide from the venom of the fish-hunting snail, Conus purpurascens, which is essential for quick prey’s excitotoxic immobilization.
David Naranjo, Ignacio Díaz-Franulic
doaj   +1 more source

Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin

Toxins, 2021
Bordetella pertussis causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor.
Carolin Kling, Arto T. Pulliainen, Holger Barth, Katharina Ernst   +3 more
doaj   +1 more source

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M., Bettelli, Estelle, Buch, Thorsten, Frommer, Friederike, Heinen, Tobias J. A. J., Mueller, Werner, Roers, Axel, Waisman, Ari, Wunderlich, F. Thomas, Yogev, Nir   +9 more
core   +1 more source

Targeting MCF-7 Cell Line by Listeriolysin O Pore Forming Toxin Fusion with AHNP Targeted Peptide

Advanced Biomedical Research, 2019
Background: Tumor-targeting peptides are attracting subjects in cancer therapy. These peptides, which are widely studied, deliver therapeutic agents to the specific sites of tumors.
Gholamreza Fotoohi-Ardakani, Majid Kheirollahi, Hossein Zarei Jaliani, Mohadese Noorian, Hossein Ansariniyia   +4 more
doaj   +1 more source

Toxin diversity revealed by a transcriptomic study of Ornithoctonus huwena. [PDF]

PLoS ONE, 2014
Spider venom comprises a mixture of compounds with diverse biological activities, which are used to capture prey and defend against predators. The peptide components bind a broad range of cellular targets with high affinity and selectivity, and appear to
Yiya Zhang, Yong Huang, Quanze He, Jinyan Liu, Ji Luo, Li Zhu, Shanshan Lu, Pengfei Huang, Xinyi Chen, Xiongzhi Zeng, Songping Liang   +10 more
doaj   +1 more source

YoeB toxin is activated during thermal stress. [PDF]

, 2015
Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando, Hayes, Christopher S, Janssen, Brian D   +2 more
core   +1 more source

A large scale prediction of bacteriocin gene blocks suggests a wide functional spectrum for bacteriocins

, 2015
Bacteriocins are peptide-derived molecules produced by bacteria, whose recently-discovered functions include virulence factors and signalling molecules as well as their better known roles as antibiotics.
Freed, Stefan D, Friedberg, Iddo, Lee, Shaun W, Morton, James T   +3 more
core   +1 more source

The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex [PDF]

, 2013
The Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia.
A Sisto, AE Lang, C Gatsogiannis, C McNulty, CP Silva, D Bowen, D Liu, D Zhang, DL Erickson, EF Boyd, Frederick M. Ausubel, G Yang, Guowei Yang, H Gotoh, H Li, I Gendlina, J Soding, JJ Sheets, M Blackburn, M Blackburn, M Sergeant, MC Hares, MJ Landsberg, MR Hurst, N Waterfield, N Waterfield, Nicholas R. Waterfield, NR Waterfield, NR Waterfield, NR Waterfield, R Ffrench-Constant, R Zhao, SC Lee, SK Aoki, SM Tennant, VL Kung, YD Wang, ZC Ruhe   +37 more
core   +3 more sources

Biologically Active Peptides in Physalia Toxin.

Experimental Biology and Medicine, 1961
Summary and conclusionsThe crude toxin of Physalia nematocysts withstands lyophilization without significant loss of toxicity. Physalia toxin may be separated into component peptides by one-dimensional chromatography in 80% aqueous n-propanol. Each of the resultant peptides retains considerable toxicity for the fiddler crab, Uca pugilator.
C E, LANE, B W, COURSEN, K, HINES
openaire   +2 more sources