Results 31 to 40 of about 183,535 (259)
A novel RRGW derived peptide is a promising inhibitor of BoNT/A
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Clostridium botulinum neurotoxin type A (BoNT/A) is one of the most potent biotoxins ever known. Its entry into neurons could block vesicle exocytosis to abolish the release of neurotransmitters from nerve terminals, thus leading to muscle paralysis ...
Wantong Ma +10 more
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Marine Drugs, 2020 κ-Conotoxin-PVIIA (κ-PVIIA) is a potassium-channel blocking peptide from the venom of the fish-hunting snail, Conus purpurascens, which is essential for quick prey’s excitotoxic immobilization.
David Naranjo, Ignacio Díaz-Franulic
doaj +1 more source
Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin
Toxins, 2021 Bordetella pertussis causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor.
Carolin Kling +3 more
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Toxins, 2018 Exploring the interaction of ligands with voltage-gated sodium channels (NaVs) has advanced our understanding of their pharmacology. Herein, we report the purification and characterization of a novel non-selective mammalian and bacterial NaVs toxin, JZTx-
Jie Zhang +6 more
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Targeting MCF-7 Cell Line by Listeriolysin O Pore Forming Toxin Fusion with AHNP Targeted Peptide
Advanced Biomedical Research, 2019 Background: Tumor-targeting peptides are attracting subjects in cancer therapy. These peptides, which are widely studied, deliver therapeutic agents to the specific sites of tumors.
Gholamreza Fotoohi-Ardakani +4 more
doaj +1 more source
Toxin diversity revealed by a transcriptomic study of Ornithoctonus huwena. [PDF]
PLoS ONE, 2014 Spider venom comprises a mixture of compounds with diverse biological activities, which are used to capture prey and defend against predators. The peptide components bind a broad range of cellular targets with high affinity and selectivity, and appear to
Yiya Zhang +10 more
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Biologically Active Peptides in Physalia Toxin.
Experimental Biology and Medicine, 1961 Summary and conclusionsThe crude toxin of Physalia nematocysts withstands lyophilization without significant loss of toxicity. Physalia toxin may be separated into component peptides by one-dimensional chromatography in 80% aqueous n-propanol. Each of the resultant peptides retains considerable toxicity for the fiddler crab, Uca pugilator.
C E, LANE, B W, COURSEN, K, HINES
openaire +2 more sources
Peptide-Conjugated Pterins as Inhibitors of Ricin Toxin A [PDF]
Journal of Medicinal Chemistry, 2012 Several 7-peptide-substituted pterins were synthesized and tested as competitive active-site inhibitors of ricin toxin A (RTA). Focus began on dipeptide conjugates, and these results further guided the construction of several tripeptide conjugates. The binding of these compounds to RTA was studied via a luminescence-based kinetic assay, as well as ...
Ryota, Saito +8 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source