Results 21 to 30 of about 186,549 (302)

Cloning and Characterization of a Cyclic Peptide Synthetase Gene from Alternaria alternata Apple Pathotype Whose Product Is Involved in AM-Toxin Synthesis and Pathogenicity

Molecular Plant-Microbe Interactions, 2000
Alternaria alternata apple pathotype causes Alternaria blotch of susceptible apple cultivars through the production of a cyclic peptide host-specific toxin, AM-toxin.
R. D. Johnson, L. Johnson, Y. Itoh, M. Kodama, H. Otani, K. Kohmoto   +5 more
doaj   +1 more source

High yield production and refolding of the double-knot toxin, an activator of TRPV1 channels. [PDF]

PLoS ONE, 2012
A unique peptide toxin, named double-knot toxin (DkTx), was recently purified from the venom of the tarantula Ornithoctonus huwena and was found to stably activate TRPV1 channels by targeting the outer pore domain.
Chanhyung Bae, Jeet Kalia, Inhye Song, JeongHeon Yu, Ha Hyung Kim, Kenton J Swartz, Jae Il Kim   +6 more
doaj   +1 more source

Toxins and antimicrobial peptides: interactions with membranes [PDF]

SPIE Proceedings, 2009
The innate immunity to pathogenic invasion of organisms in the plant and animal kingdoms relies upon cationic antimicrobial peptides (AMPs) as the first line of defense. In addition to these natural peptide antibiotics, similar cationic peptides, such as the bee venom toxin melittin, act as nonspecific toxins. Molecular details of AMP and peptide toxin
Diana E, Schlamadinger, Jonathan E, Gable, Judy E, Kim   +2 more
openaire   +2 more sources

Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer [PDF]

, 2006
Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple ...
Jennings, Keith R., Scrivens, JH, Williams, Jonathan P., Scrivens, James H., Williams, JP, Roberts, LM, Marsden, Brian D., Smith, Daniel C., Marsden, BD, Smith, DC, Roberts, Lynne M., Scrivens, James, Green, BN, Green, Brian N., Roberts, L. M. (Lynne M.), Jennings, KR   +15 more
core   +1 more source

An in silico insight into novel therapeutic interaction of LTNF peptide-LT10 and design of structure based peptidomimetics for putative anti-diabetic activity. [PDF]

PLoS ONE, 2015
Lethal Toxin Neutralizing Factor (LTNF) obtained from Opossum serum (Didephis virginiana) is known to exhibit toxin-neutralizing activity for envenomation caused by animals, plants and bacteria.
Sonali Gopichand Chavan, Deepti Dileep Deobagkar   +1 more
doaj   +1 more source

Molecular Diversity of Peptide Toxins in the Venom of Spider Heteropoda pingtungensis as Revealed by cDNA Library and Transcriptome Sequencing Analysis

Toxins, 2022
The venoms of toxic animals are chemical pools composed of various proteins, peptides, and small organic molecules used for predation and defense, in which the peptidic toxins have been intensively pursued mining modulators targeting disease-related ion ...
Qingyi Liao, Xiangjin Kong, Guoqing Luo, Xiangyue Wu, Yinping Li, Qicai Liu, Cheng Tang, Zhonghua Liu   +7 more
doaj   +1 more source

Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins [PDF]

mBio, 2022
Pathogenic fungi kill an estimated 1.5 million people every year. Recently, we discovered that the fungal pathogen Candida albicans secretes a peptide toxin called candidalysin during mucosal infection.
Richardson, Jonathan, Brown, Rhys, Kichik, Nessim, Lee, Sejeong, Priest, Emily, Mogavero, Selene, Maufrais, Corinne, Wickramasinghe, Don, Tsavou, Antzela, Kotowicz, Natalia, Hepworth, Olivia, Gallego-Cortés, Ana, Ponde, Nicole, Ho, Jemima, Moyes, David, Wilson, Duncan, D'Enfert, Christophe, Hube, Bernhard, Naglik, Julian   +18 more
openaire   +4 more sources

Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]

, 2012
Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050), J Michael Lord, Roberts Lynne M., Spooner, Robert A., Hampton Randolph Y., Lord J. Michael, Robert A. Spooner (150027), Spooner Robert A., Lord, J. Michael, Shuyu Li (18735), Roberts, Lynne M., Randolph Y Hampton, Lynne M Roberts, Shuyu Li, Lord, Mike, J. Michael Lord (150042), Li, Shuyu, Roberts, L. M. (Lynne M.), Robert A Spooner, Randolph Y. Hampton (150034), Li Shuyu, Hampton, Randolph Y.   +21 more
core   +1 more source

Isolation and cDNA cloning of four peptide toxins from the sea anemone Heteractis aurora [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Sea anemones are well known to contain multiple peptide toxins. However, of more than 1100 species of sea anemones distributed worldwide, only a little over 50 have been studied for peptide toxins.
Tomohiro Homma, Masami Ishida, Yuji Nagashima, Kazuo Shiomi   +3 more
doaj   +1 more source

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source