Results 1 to 10 of about 1,817,760 (259)

Trends in urine sampling rates of general practice patients with suspected lower urinary tract infections in England, 2015–2022: a population-based study

BMJ Open
Objectives Inappropriate prescribing of antibiotics is a key driver of antimicrobial resistance. This study aimed to describe urine sampling rates and antibiotic prescribing for patients with lower urinary tract infections (UTIs) in English general ...
Berit Muller-Pebody, Alicia Demirjian, Elizabeth Beech, Colin S Brown, Laura Ciaccio, Holly Fountain, Sarah Gerver, Sabine Bou-Antoun   +7 more
doaj   +1 more source

Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence

mBio, 2020
There is an urgent need to develop novel antifungals to tackle the threat fungal pathogens pose to human health. Here, we have performed a comprehensive characterization and validation of the promising target methionine synthase (MetH).
Jennifer Scott, Monica Sueiro-Olivares, Benjamin P. Thornton, Rebecca A. Owens, Howbeer Muhamadali, Rachael Fortune-Grant, Darren Thomson, Riba Thomas, Katherine Hollywood, Sean Doyle, Royston Goodacre, Lydia Tabernero, Elaine Bignell, Jorge Amich   +13 more
doaj   +1 more source

The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target

Virulence
Sulfur metabolism is an essential aspect of fungal physiology and pathogenicity. Fungal sulfur metabolism comprises anabolic and catabolic routes that are not well conserved in mammals, therefore is considered a promising source of prospective novel ...
Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich   +11 more
doaj   +1 more source

Epithelial uptake leads to fungal killing in vivo and is aberrant in COPD-derived epithelial cells

iScience
Summary: Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings, representing a constant, possibly fatal, threat to respiratory health.
Margherita Bertuzzi, Gareth J. Howell, Darren D. Thomson, Rachael Fortune-Grant, Anna Möslinger, Patrick Dancer, Norman Van Rhijn, Natasha Motsi, Alice Codling, Elaine M. Bignell   +9 more
doaj   +1 more source

Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection

Frontiers in Microbiology, 2019
Pathogen-pathogen interactions in polymicrobial infections are known to directly impact, often to worsen, disease outcomes. For example, co-infection with Pseudomonas aeruginosa and Aspergillus fumigatus, respectively the most common bacterial and fungal
Jennifer Scott, Monica Sueiro-Olivares, Waqar Ahmed, Waqar Ahmed, Christoph Heddergott, Can Zhao, Riba Thomas, Michael Bromley, Jean-Paul Latgé, Sven Krappmann, Stephen Fowler, Stephen Fowler, Elaine Bignell, Jorge Amich   +13 more
doaj   +1 more source

Cryptococcus displays spore-specific uptake by alveolar epithelial cells

mBio
Human fungal pathogens, including Cryptococcus neoformans, cause 1.5 million annual deaths. Cryptococcus causes disease when it disseminates out of the lung and into the brain, which can occur years after initial exposure (latency) via mechanisms that ...
Sébastien C. Ortiz, Rachael Fortune-Grant, Andrew J. Thom, Joshua Davies, Robin C. May, Rebecca A. Drummond, Margherita Bertuzzi   +6 more
doaj   +1 more source

Imported fungal infections [PDF]

Postgraduate Medical Journal, 1979
Summary Data on mycoses known to be imported into the United Kingdom are sparse. Estimates on the prevalence of fungal infections have to be based on indirect and incomplete figures, obtained from isolation figures and reports of individual cases to co-ordinating centres such as the Mycological Reference Laboratory and the Communicable ...
openaire   +2 more sources

Coordinated regulation of pH alkalinization by two transcription factors promotes fungal commensalism and pathogenicity

Nature Communications
As a clinically relevant opportunistic human fungal pathogen, Candida albicans is able to rapidly sense and adapt to changing microenvironments within the host, a process that is essential for its successful invasion and survival.
Xinhua Huang, Guangsheng Chen, Lei Wu, Yun Zou, Luyao Zhang, Shanshan Li, Kunlin Li, Zaijie Jiang, Yuping Zhang, Xiaoqing Chen, Winnie Shum, Jianbiao Dai, Huichang Huang, Munika Moses, Xianwei Wu, Yuanyuan Wang, Tong Jiang, Zhiyi He, Qing Guo, Wenwen Xue, Hao Li, Changbin Chen   +21 more
doaj   +1 more source

Whole-Genome Sequencing and Comparative Genomic Analysis of Three Clinical Bloodstream Infection Isolates of Trichosporon austroamericanum

Journal of Fungi
Trichosporon austroamericanum is a recently described yeast species related to Trichosporon inkin and exclusively isolated from clinical specimens. However, its genomic features and pathogenic potential remain poorly understood.
Takanori Horiguchi, Takashi Umeyama, Hiroko Tomuro, Amato Otani, Takayuki Shinohara, Masahiro Abe, Shogo Takatsuka, Ken Miyazawa, Minoru Nagi, Yasunori Muraosa, Yasutaka Hoshino, Takashi Sakoh, Hideki Araoka, Naoyuki Uchida, Tomoyoshi Kaneko, Yuko Nagano, Hiroki Tsukada, Taiga Miyazaki, Yoshitsugu Miyazaki   +18 more
doaj   +1 more source

Oxidoreductase gene fabG contributes to fungal development, cell wall integrity, and virulence in Aspergillus fumigatus

Microbiology Spectrum
Aspergillus fumigatus, a major cause of invasive aspergillosis, relies on oxidoreductases for stress adaptation. The role of the oxidoreductase gene fabG in fungal physiology and virulence remains unclear.
Heng Zhang, Hua Ni, Xinyi Tao, Tian Chen, Yi Zhang, Xiaolei Zhu, Yinping Chen, Mengqi Peng, Yi Sun   +8 more
doaj   +1 more source