MBioCandida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation ...
Sandra Timme
exaly +3 more sources
Global fungal-host interactome mapping identifies host targets of candidalysin
Nature CommunicationsCandidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped.
Tian-Yi Zhang +24 more
doaj +3 more sources
Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by
mBio, 2019 Candida albicans is an opportunistic fungal pathogen that can cause life-threatening infections, particularly in immunocompromised patients. C. albicans induced activation of the Nlrp3 inflammasome, leading to secretion of bioactive interleukin 1β (IL-1β)
Ona Rogiers +6 more
doaj +5 more sources
Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice [PDF]
VirulenceVulvovaginal candidiasis (VVC) is a prevalent fungal infection primarily caused by the opportunistic pathogen Candida albicans. Among women affected by VVC, up to 8% experience more than four episodes per year, regarded as recurrent vulvovaginal ...
Julie Auffray +6 more
doaj +2 more sources
Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins, 2022 The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders ...
Pedro Henrique de Oliveira Cardoso +10 more
doaj +3 more sources
PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape. [PDF]
PLoS ONEThe fundamental molecules of life are polymers. Prominent examples include nucleic acids and proteins, both of which exhibit a large array of mechanical properties and three-dimensional shapes. The bending rigidity of individual polymers is quantified by
Elizabeth A Conley +6 more
doaj +2 more sources
The Cytotoxic Effect of Candidalysin on Primary Human Gingival Fibroblasts: An In Vitro Study
Galician Medical JournalIntroduction. This study aimed to investigate the cytotoxic and functional effects of candidalysin, a cytolytic peptide toxin produced by Candida albicans, on primary human gingival fibroblasts (hGFs). Methods.
Elham Alsahafi, Abdel-Rahman Youssef
doaj +3 more sources
Beyond colonization: Candida albicans exhibits substantial pathogenic potential in cystic fibrosis environments [PDF]
npj Biofilms and MicrobiomesCystic fibrosis (CF) sputum represents a highly permissive niche for microbial colonization, yet the contribution of Candida albicans to disease progression remains insufficiently investigated despite its frequent detection in CF airways. We hypothesized
Natasa Radakovic +8 more
doaj +2 more sources
EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway [PDF]
VirulenceCandida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson +6 more
doaj +2 more sources
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor [PDF]
Nature Communications, 2019 Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Jemima Ho +18 more
doaj +6 more sources