Results 21 to 30 of about 1,214 (146)

The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease [PDF]

Journal of Hepatology, 2020
Alcohol-associated liver disease is a leading indication for liver transplantation and a leading cause of mortality. Alterations to the gut microbiota contribute to the pathogenesis of alcohol-associated liver disease. Patients with alcohol-associated liver disease have increased proportions of Candida spp.
Huikuan Chu, Yi Duan, Sonja Lang, Lu Jiang, Yanhan Wang, Cristina Llorente, Jinyuan Liu, Selene Mogavero, Francisco Bosques-Padilla, Juan G. Abraldes, Victor Vargas, Xin M. Tu, Ling Yang, Xiaohua Hou, Bernhard Hube, Peter Stärkel, Bernd Schnabl   +16 more
openaire   +4 more sources

Candida albicans and candidalysin in inflammatory disorders and cancer [PDF]

Immunology, 2020
SummaryAs our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C.
Jemima Ho, Giorgio Camilli, James S. Griffiths, Jonathan P. Richardson, Nessim Kichik, Julian R. Naglik   +5 more
openaire   +4 more sources

Solubility affects IL-1β-producing activity of the synthetic candidalysin peptide.

PLoS ONE, 2022
Candidalysin, a peptide toxin produced specifically from hyphae of Candida albicans, plays a crucial role in C. albicans pathogenesis in the oral cavity and vagina.
Taiki Mori, Hideo Kataoka, Gen Tanabe, Takeshi Into   +3 more
doaj   +3 more sources

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

mBio
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation ...
Marisa Valentine, Paul Rudolph, Axel Dietschmann, Antzela Tsavou, Selene Mogavero, Sejeong Lee, Emily L. Priest, Gaukhar Zhurgenbayeva, Nadja Jablonowski, Sandra Timme, Christian Eggeling, Stefanie Allert, Edward Dolk, Julian R. Naglik, Marc T. Figge, Mark S. Gresnigt, Bernhard Hube   +16 more
doaj   +2 more sources

Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response [PDF]

Innovations in Digital Health, Diagnostics, and Biomarkers, 2021
The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the
Yao-Qi Chen, Qian Li, Tian-Yi Zhang, Ning-Ning Liu   +3 more
doaj   +3 more sources

Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection [PDF]

The Journal of Infectious Diseases, 2019
AbstractBackgroundCandidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. Candidalysin is critical for mucosal C albicans infections and is known to activate epithelial cells to induce downstream innate immune responses that are associated with protection or ...
Swidergall, M., Khalaji, M., Solis, N.V., Moyes, D.L., Drummond, R.A., Hube, B., Lionakis, M.S., Murdoch, C., Filler, S.G., Naglik, J.R.   +9 more
openaire   +6 more sources

Discovery of the High-Affinity Aptamer for Candidalysin Using a Dual-Mode Colorimetric–SERS Platform [PDF]

Biosensors
Candida albicans poses significant health risks through its virulent peptide toxin Candidalysin. As no existing therapeutics specifically target this toxin, developing high-affinity aptamers for its efficient and safe removal is urgently needed.
Yige Sun, Canlan Zheng, Yuxuan Shi, Mingyuan Sun, Chao Wang, Lin Han, Yu Zhang, Tiezhou Hou, Le Qiang   +8 more
doaj   +2 more sources

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence [PDF]

mBio, 2018
Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson, Selene Mogavero, David L. Moyes, Mariana Blagojevic, Thomas Krüger, Akash H. Verma, Bianca M. Coleman, Jacinto De La Cruz Diaz, Daniela Schulz, Nicole O. Ponde, Giulia Carrano, Olaf Kniemeyer, Duncan Wilson, Oliver Bader, Simona I. Enoiu, Jemima Ho, Nessim Kichik, Sarah L. Gaffen, Bernhard Hube, Julian R. Naglik   +19 more
doaj   +7 more sources

The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis [PDF]

Journal of Oral Pathology & Medicine, 2020
AbstractOral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection. Previous studies have highlighted Candida albicans host tissue infection as a risk factor in the initiation and progression of oral cancer.
Engku Anis Fariha Engku Nasrullah Satiman, Hasna Ahmad, Ahmad Bazli Ramzi, Ridhwan Abdul Wahab, Mohd Arifin Kaderi, Wan Himratul Aznita Wan Harun, Stuart Dashper, Michael McCullough, Mohd Hafiz Arzmi   +8 more
openaire   +4 more sources

The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence

Toxins, 2020
The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König, Bernhard Hube, Lydia Kasper   +2 more
doaj   +2 more sources