Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by
mBio, 2019 Candida albicans is an opportunistic fungal pathogen that can cause life-threatening infections, particularly in immunocompromised patients. C. albicans induced activation of the Nlrp3 inflammasome, leading to secretion of bioactive interleukin 1β (IL-1β)
Ona Rogiers +6 more
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Candida albicans-induced ubiquitination of EGFR reveals novel host–fungal interaction pathways [PDF]
mBioCandida albicans causes severe mucosal and systemic infections, with hypha formation playing a key role in its virulence. Hyphal invasion via endocytosis is mediated predominantly through interactions between Als3p and the epidermal growth factor ...
Léa Lortal +12 more
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Mucosal immune response modulated by secreted and membrane-bound hydrolases of Candida albicans in vulvovaginal candidiasis [PDF]
Frontiers in Fungal BiologyVulvovaginal candidiasis (VVC) affects the physical and mental health of millions of women worldwide. The leading cause of VVC, Candida albicans, can induce a strong mucosal inflammatory reaction during the VVC infection, where secreted and membrane ...
Guocheng Qian +4 more
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Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor [PDF]
Nature Communications, 2019 Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Jemima Ho +18 more
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Peptide YY reduces cytotoxicity of Candida albicans in alcohol-associated liver disease [PDF]
JHEP ReportsBackground & Aims: Transitioning from yeast to hyphal morphology enables Candida albicans (C. albicans) to secrete candidalysin, invade the intestinal mucosa and translocate to the blood stream.
Henriette Kreimeyer +11 more
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Indian Journal of Dental ResearchBackground: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).
Mani B. Subramani +4 more
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The transcription factor Ahr1 governs the recruitment of neutrophils to the brain and clearance of Candida albicans during CNS infection [PDF]
mBioCandida albicans causes infections of the central nervous system in premature infants and people with primary immune deficiencies affecting the innate immune system.
Rohan S. Wakade +5 more
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Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice [PDF]
VirulenceVulvovaginal candidiasis (VVC) is a prevalent fungal infection primarily caused by the opportunistic pathogen Candida albicans. Among women affected by VVC, up to 8% experience more than four episodes per year, regarded as recurrent vulvovaginal ...
Julie Auffray +6 more
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PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape. [PDF]
PLoS ONEThe fundamental molecules of life are polymers. Prominent examples include nucleic acids and proteins, both of which exhibit a large array of mechanical properties and three-dimensional shapes. The bending rigidity of individual polymers is quantified by
Elizabeth A Conley +6 more
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An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans [PDF]
Nature CommunicationsCandida albicans is a ubiquitous fungus in the human gut yet there is little understanding as to how crosstalk between the fungus and the host regulates gut colonization.
Pallavi Kakade +17 more
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