Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells [PDF]
Cells, 2020 Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to ...
Jonathan Richardson +2 more
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Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins [PDF]
mBio, 2022 Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems.
Jonathan P. Richardson +18 more
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Candidalysin Is the Hemolytic Factor of Candida albicans
Toxins, 2022 Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C.
Selene Mogavero +11 more
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Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis. [PDF]
PLoS PathogensCandida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces.
Kuo-Yao Tseng +13 more
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Solubility affects IL-1β-producing activity of the synthetic candidalysin peptide.
PLoS ONE, 2022 Candidalysin, a peptide toxin produced specifically from hyphae of Candida albicans, plays a crucial role in C. albicans pathogenesis in the oral cavity and vagina.
Taiki Mori +3 more
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Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the
Yao-Qi Chen +3 more
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Processing of
mBio, 2018 Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson +19 more
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Mucosal immune response modulated by secreted and membrane-bound hydrolases of Candida albicans in vulvovaginal candidiasis [PDF]
Frontiers in Fungal BiologyVulvovaginal candidiasis (VVC) affects the physical and mental health of millions of women worldwide. The leading cause of VVC, Candida albicans, can induce a strong mucosal inflammatory reaction during the VVC infection, where secreted and membrane ...
Guocheng Qian +4 more
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Peptide YY reduces cytotoxicity of Candida albicans in alcohol-associated liver disease [PDF]
JHEP ReportsBackground & Aims: Transitioning from yeast to hyphal morphology enables Candida albicans (C. albicans) to secrete candidalysin, invade the intestinal mucosa and translocate to the blood stream.
Henriette Kreimeyer +11 more
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Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses [PDF]
Infection and ImmunityExtracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication.
Sejeong Lee +12 more
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