Results 11 to 20 of about 1,341 (134)
ToxinsCandida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract of healthy humans. Under certain conditions, it can become invasive and cause life-threatening systemic infections.
Moran Morelli
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The combinatorial action of hyphal growth and candidalysin is critical for promoting Candida albicans oropharyngeal infection [PDF]
mBioCandida albicans is one of the most common fungal pathogens, yet much remains unknown about how its virulence factors cooperate to promote pathogenicity. To investigate this, CRISPR-Cas9 technology was used to create a panel of 19 single, double, triple,
Olivia K. A. Paulin +13 more
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Candidalysin Is the Hemolytic Factor of Candida albicans
Toxins, 2022 Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C.
Selene Mogavero +11 more
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mBioCandida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation ...
Marisa Valentine +16 more
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Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins [PDF]
mBio, 2022 Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems.
Jonathan P. Richardson +18 more
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Global fungal-host interactome mapping identifies host targets of candidalysin
Nature CommunicationsCandidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped.
Tian-Yi Zhang +24 more
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Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis [PDF]
Cell Reports, 2023 Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and
Yifan Wu +19 more
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Toxins, 2020 The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König +2 more
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Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.
PLoS Pathogens, 2021 During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
Marc Swidergall +10 more
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The Cytotoxic Effect of Candidalysin on Primary Human Gingival Fibroblasts: An In Vitro Study [PDF]
Galician Medical JournalIntroduction. This study aimed to investigate the cytotoxic and functional effects of candidalysin, a cytolytic peptide toxin produced by Candida albicans, on primary human gingival fibroblasts (hGFs). Methods.
Elham Alsahafi, Abdel-Rahman Youssef
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