Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by
mBio, 2019 Candida albicans is an opportunistic fungal pathogen that can cause life-threatening infections, particularly in immunocompromised patients. C. albicans induced activation of the Nlrp3 inflammasome, leading to secretion of bioactive interleukin 1β (IL-1β)
Ona Rogiers +6 more
doaj +6 more sources
Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin [PDF]
Nature MicrobiologyCandidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive. Here we performed a genome-wide loss-of-function CRISPR screen in the TR146 human oral epithelial cell line and identified that disruption of genes (XYLT2, B3GALT6 and B3GAT3) in glycosaminoglycan
Jianfeng Lin +16 more
europepmc +6 more sources
The combinatorial action of hyphal growth and candidalysin is critical for promoting Candida albicans oropharyngeal infection [PDF]
mBioCandida albicans is one of the most common fungal pathogens, yet much remains unknown about how its virulence factors cooperate to promote pathogenicity. To investigate this, CRISPR-Cas9 technology was used to create a panel of 19 single, double, triple,
Olivia K. A. Paulin +13 more
doaj +4 more sources
Evaluating the Role of Candida albicans as a Potential Oral Carcinogen [PDF]
Interdisciplinary Perspectives on Infectious DiseasesOral cavity cancers, especially oral squamous cell carcinoma (OSCC), are a major subset of head and neck malignancies. Increasing evidence indicates that oral microbiota, particularly Candida albicans (C.
Fatemeh Amirinia +3 more
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The Cytotoxic Effect of Candidalysin on Primary Human Gingival Fibroblasts: An In Vitro Study
Galician Medical JournalIntroduction. This study aimed to investigate the cytotoxic and functional effects of candidalysin, a cytolytic peptide toxin produced by Candida albicans, on primary human gingival fibroblasts (hGFs). Methods.
Elham Alsahafi, Abdel-Rahman Youssef
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Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins, 2022 The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders ...
Pedro Henrique de Oliveira Cardoso +10 more
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Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses [PDF]
Infection and ImmunityExtracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication.
Sejeong Lee +12 more
doaj +4 more sources
Candidalysin triggers epithelial cellular stresses that induce necrotic death [PDF]
Cellular Microbiology, 2021 Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in the pathogenic process by invading epithelial cells and causing tissue damage.
Mariana Blagojevic +6 more
openaire +6 more sources
Candidalysin sets off the innate alarm [PDF]
Science Immunology, 2017 Candidalysin-induced epithelial cell damage promotes expansion of innate TCRαβ + cells during oropharyngeal candidiasis. See the related research article by Verma et al .
Xin Li, Irina Leonardi, Iliyan D. Iliev
openaire +3 more sources
EMBO reports, 2023 Abstract The peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET‐like structures (NLS), which are more compact and less fibrous than ...
Lucas Unger +12 more
core +7 more sources