Results 31 to 40 of about 1,214 (146)

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

Cell Reports, 2023
Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and
Yifan Wu, Shuqi Du, Lynn H. Bimler, Kelsey E. Mauk, Léa Lortal, Nessim Kichik, James S. Griffiths, Radim Osicka, Lizhen Song, Katherine Polsky, Lydia Kasper, Peter Sebo, Jill Weatherhead, J. Morgan Knight, Farrah Kheradmand, Hui Zheng, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik, David B. Corry   +19 more
doaj   +3 more sources

Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.

PLoS Pathogens, 2021
During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
Marc Swidergall, Norma V Solis, Nicolas Millet, Manning Y Huang, Jianfeng Lin, Quynh T Phan, Michael D Lazarus, Zeping Wang, Michael R Yeaman, Aaron P Mitchell, Scott G Filler   +10 more
doaj   +2 more sources

Hemolytic Activity of Vaginal Candida albicans Isolates and Antifungal Effects of Quinalizarin with Hemolysis Modulation [PDF]

Pathogens
This study evaluated the hemolytic activity of Candida albicans isolates from the female reproductive tract and investigated the in vitro effects of quinalizarin on fungal growth, hemolysis, and ECE1 expression. Ninety-four clinical C.
Monika Janeczko, Elżbieta Kochanowicz
doaj   +2 more sources

Candidalysin is a fungal peptide toxin critical for mucosal infection [PDF]

Nature, 2016
Published by Macmillan28177 ...
Moyes, David L.; id_orcid 0000-0002-1657-918X, Wilson, Duncan, Richardson, Jonathan P.; id_orcid 0000-0001-9638-2725, Mogavero, Selene, Tang, Shirley X., Wernecke, Julia, Hofs, Sarah, Gratacap, Remi L, Robbins, Jon, Runglall, Manohursingh, Murciano, Celia, Blagojevic, Mariana, Thavaraj, Selvam, Forster, Toni M, Hebecker, Betty, Kasper, Lydia, Vizcay-Barrena, Gema, Iancu, Simona I., Kichik, Nessim, Hader, Antje, Kurzai, Oliver, Luo, Ting, Kruger, Thomas, Kniemeyer, Olaf, Cota, Ernesto, Bader, Oliver, Bader, Oliver, Wheeler, Robert T, Gutsmann, Thomas, Hube, Bernhard, Naglik, Julian R.; id_orcid 0000-0002-8072-7917   +30 more
openaire   +8 more sources

Detection of serum anti-candidalysin IgG by indirect ELISA: a novel auxiliary tool for diagnosing invasive candidiasis in a preliminary pediatric study [PDF]

Microbiology Spectrum
Invasive candidiasis (IC) is the most common fungal infection in clinical settings, yet early diagnosis remains challenging. Candidalysin, a key virulence factor in invasive infections, exhibits site-specific pathogenicity.
Ting Luo, Xun Li, Haipeng Yan, Ling Gong, Longlong Xie, Xiangyu Wang, Jiaotian Huang, Yufan Yang, Xiao Li, Yingying Zhang, Guoping Lu, Zhenghui Xiao, Xiulan Lu   +12 more
doaj   +2 more sources

Candida albicans-induced ubiquitination of EGFR reveals novel host–fungal interaction pathways [PDF]

mBio
Candida albicans causes severe mucosal and systemic infections, with hypha formation playing a key role in its virulence. Hyphal invasion via endocytosis is mediated predominantly through interactions between Als3p and the epidermal growth factor ...
Léa Lortal, James S. Griffiths, Emily L. Priest, Alexander Kempf, Olivia K. A. Paulin, Nicole O. Ponde, Antzela Tsavou, Don N. Wickramasinghe, Andrew Donkin, Claire M. Lyon, Olivia W. Hepworth, Jonathan P. Richardson, Julian R. Naglik   +12 more
doaj   +2 more sources

Mucosal immune response modulated by secreted and membrane-bound hydrolases of Candida albicans in vulvovaginal candidiasis [PDF]

Frontiers in Fungal Biology
Vulvovaginal candidiasis (VVC) affects the physical and mental health of millions of women worldwide. The leading cause of VVC, Candida albicans, can induce a strong mucosal inflammatory reaction during the VVC infection, where secreted and membrane ...
Guocheng Qian, Li Ding, Chao Tan, Lidan Wang, Cong Long   +4 more
doaj   +2 more sources

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor [PDF]

Nature Communications, 2019
Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Jemima Ho, Xuexin Yang, Spyridoula-Angeliki Nikou, Nessim Kichik, Andrew Donkin, Nicole O. Ponde, Jonathan P. Richardson, Remi L. Gratacap, Linda S. Archambault, Christian P. Zwirner, Celia Murciano, Rhonda Henley-Smith, Selvam Thavaraj, Christopher J. Tynan, Sarah L. Gaffen, Bernhard Hube, Robert T. Wheeler, David L. Moyes, Julian R. Naglik   +18 more
doaj   +2 more sources

Peptide YY reduces cytotoxicity of Candida albicans in alcohol-associated liver disease [PDF]

JHEP Reports
Background & Aims: Transitioning from yeast to hyphal morphology enables Candida albicans (C. albicans) to secrete candidalysin, invade the intestinal mucosa and translocate to the blood stream.
Henriette Kreimeyer, Marcos F. Fondevila, Aenne Harberts, Fernanda Raya Tonetti, David Schöler, Eliane Münte, Phillipp Hartmann, Cristina Llorente, Bernhard Hube, Salomé LeibundGut-Landmann, Peter Stärkel, Bernd Schnabl   +11 more
doaj   +2 more sources

Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Indian Journal of Dental Research
Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).
Mani B. Subramani, Krishnan Mahalakshmi, Bharathy Jaya, Sankar Leena Sankari, Venkatesan N. Kumar   +4 more
doaj   +2 more sources