Results 31 to 40 of about 1,628 (159)

Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin

Toxins, 2022
The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders ...
Pedro Henrique de Oliveira Cardoso, Ana Paula de Araújo Boleti, Patrícia Souza e Silva, Lincoln Takashi Hota Mukoyama, Alexya Sandim Guindo, Luiz Filipe Ramalho Nunes de Moraes, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Cristiano Marcelo Espínola Carvalho, Alinne Pereira de Castro, Ludovico Migliolo   +10 more
doaj   +3 more sources

Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice [PDF]

Virulence
Vulvovaginal candidiasis (VVC) is a prevalent fungal infection primarily caused by the opportunistic pathogen Candida albicans. Among women affected by VVC, up to 8% experience more than four episodes per year, regarded as recurrent vulvovaginal ...
Julie Auffray, Nicolas Biteau, Anne Cayrel, Denis Dacheux, Hassana Hsein, Pierre Tchoreloff, Thierry Noel   +6 more
doaj   +2 more sources

PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape. [PDF]

PLoS ONE
The fundamental molecules of life are polymers. Prominent examples include nucleic acids and proteins, both of which exhibit a large array of mechanical properties and three-dimensional shapes. The bending rigidity of individual polymers is quantified by
Elizabeth A Conley, Creighton M Lisowski, Katherine G Schaefer, Harrison C Davison, Julie E Baguio, Ioan Kosztin, Gavin M King   +6 more
doaj   +2 more sources

The pathogenicity and future treatment strategies of Candida albicans [PDF]

Frontiers in Cellular and Infection Microbiology
Candida albicans (C. albicans) is a major pathogenic fungus that severely impacts on human health. This review systematically elaborates on the key pathogenic processes of C.
Jiadi Wu, Jiadi Wu, Chenyang Jiang, Hui Wang, Tongbin Chen, Xi Chen, Wenyue Da   +6 more
doaj   +2 more sources

Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection [PDF]

The Journal of Infectious Diseases, 2019
BackgroundCandidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis.
Drummond, Rebecca A, Filler, Scott G, Hube, Bernhard, Khalaji, Mina, Lionakis, Michail S, Moyes, David L, Murdoch, Craig, Naglik, Julian R, Solis, Norma V, Swidergall, Marc   +9 more
core   +7 more sources

The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis [PDF]

Journal of Oral Pathology & Medicine, 2020
Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection.
Abdul Wahab, Ridhwan, Ahmad, Hasna, Arzmi, Mohd Hafiz, Dashper, Stuart, Engku Nasrullah Satiman, Engku Anis Fariha, Kaderi, Mohd Arifin, McCullough, Michael, Ramzi, Ahmad Bazli, Wan Harun, Wan Himratul Aznita   +8 more
core   +4 more sources

Beyond colonization: Candida albicans exhibits substantial pathogenic potential in cystic fibrosis environments [PDF]

npj Biofilms and Microbiomes
Cystic fibrosis (CF) sputum represents a highly permissive niche for microbial colonization, yet the contribution of Candida albicans to disease progression remains insufficiently investigated despite its frequent detection in CF airways. We hypothesized
Natasa Radakovic, Nikola Plackic, Jelena Djuris, Joachim Morschhäuser, Aleksandar Sovtic, Mihail Basa, Predrag Minic, Fabio Zobi, Aleksandar Pavic   +8 more
doaj   +2 more sources

Essential role of hepcidin in host resistance to disseminated candidiasis [PDF]

Cell Reports
Summary: Candida albicans is a leading cause of life-threatening invasive infection despite antifungal therapy. Patients with chronic liver disease are at increased risk of candidemia, but the mechanisms underlying this susceptibility are incompletely ...
Tanmay Arekar, Divya Katikaneni, Sadat Kasem, Dhruv Desai, Thrisha Acharya, Augustina Cole, Nazli Khodayari, Sophie Vaulont, Bernhard Hube, Elizabeta Nemeth, Alexander Drakesmith, Michail S. Lionakis, Borna Mehrad, Yogesh Scindia   +13 more
doaj   +2 more sources

Pectins mitigate Candidalysin-induced gut barrier disruption and inflammation in vitro in a degree of methyl-esterification-dependent manner [PDF]

Food Hydrocolloids for Health
Pectin, a dietary fiber, exhibits anti-inflammatory properties influenced by its degree of methyl-esterification (DM). Inflammatory bowel disease (IBD) is characterized by chronic inflammation due to a compromised epithelial barrier, dysregulated ...
Naschla Gasaly, Xiaochen Chen, Luis Silva-Lagos, Isaura Beatriz Borges Silva, Marcela A. Hermoso, Paul de Vos   +5 more
doaj   +3 more sources

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes [PDF]

Nature Communications, 2018
Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging
Lydia Kasper, Annika König, Paul-Albert Koenig, Mark S. Gresnigt, Johannes Westman, Rebecca A. Drummond, Michail S. Lionakis, Olaf Groß, Jürgen Ruland, Julian R. Naglik, Bernhard Hube   +10 more
doaj   +8 more sources