Delineating the Concerted Action of Virulence Attributes in Candida albicans Systemic Infection. [PDF]
J Cell Mol MedJournal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
Paulin OKA +8 more
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Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses [PDF]
Infection and ImmunityExtracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication.
Sejeong Lee +12 more
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The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes [PDF]
Nature Communications, 2018 Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging
Lydia Kasper +10 more
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Candidalysin triggers epithelial cellular stresses that induce necrotic death [PDF]
, 2021 Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis.
Blagojevic, Mariana +6 more
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Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the
Yao-Qi Chen +3 more
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From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression. [PDF]
MicrobiologyopenRecent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Jerez JR +3 more
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Solubility affects IL-1β-producing activity of the synthetic candidalysin peptide.
PLoS ONE, 2022 Candidalysin, a peptide toxin produced specifically from hyphae of Candida albicans, plays a crucial role in C. albicans pathogenesis in the oral cavity and vagina.
Taiki Mori +3 more
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, 2023 The peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET-like structures (NLS), which are more compact and less ...
Skoluda, S. +12 more
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Processing of
mBio, 2018 Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson +19 more
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Evaluating the Role of <i>Candida albicans</i> as a Potential Oral Carcinogen. [PDF]
Interdiscip Perspect Infect DisOral cavity cancers, especially oral squamous cell carcinoma (OSCC), are a major subset of head and neck malignancies. Increasing evidence indicates that oral microbiota, particularly Candida albicans (C. albicans), plays a significant role in OSCC development and progression. While C.
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