Results 31 to 40 of about 1,079 (138)

Candidalysin triggers epithelial cellular stresses that induce necrotic death [PDF]

Cellular Microbiology, 2021
Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in the pathogenic process by invading epithelial cells and causing tissue damage.
Mariana Blagojevic, Giorgio Camilli, Michelle Maxson, Bernhard Hube, David L. Moyes, Jonathan P. Richardson, Julian R. Naglik   +6 more
openaire   +4 more sources

Candida albicans and candidalysin in inflammatory disorders and cancer [PDF]

Immunology, 2020
SummaryAs our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C.
Jemima Ho, Giorgio Camilli, James S. Griffiths, Jonathan P. Richardson, Nessim Kichik, Julian R. Naglik   +5 more
openaire   +3 more sources

Evaluating the Role of <i>Candida albicans</i> as a Potential Oral Carcinogen. [PDF]

Interdiscip Perspect Infect Dis
Oral cavity cancers, especially oral squamous cell carcinoma (OSCC), are a major subset of head and neck malignancies. Increasing evidence indicates that oral microbiota, particularly Candida albicans (C. albicans), plays a significant role in OSCC development and progression. While C.
Amirinia F, Motamedi M, Ardi P, Jabrodini A.   +3 more
europepmc   +2 more sources

Candidalysin sets off the innate alarm [PDF]

Science Immunology, 2017
Candidalysin-induced epithelial cell damage promotes expansion of innate TCRαβ + cells during oropharyngeal candidiasis. See the related research article by Verma et al .
Xin Li, Irina Leonardi, Iliyan D. Iliev
openaire   +2 more sources

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

Cell Reports, 2023
Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and
Yifan Wu, Shuqi Du, Lynn H. Bimler, Kelsey E. Mauk, Léa Lortal, Nessim Kichik, James S. Griffiths, Radim Osicka, Lizhen Song, Katherine Polsky, Lydia Kasper, Peter Sebo, Jill Weatherhead, J. Morgan Knight, Farrah Kheradmand, Hui Zheng, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik, David B. Corry   +19 more
doaj   +1 more source

Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.

PLoS Pathogens, 2021
During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
Marc Swidergall, Norma V Solis, Nicolas Millet, Manning Y Huang, Jianfeng Lin, Quynh T Phan, Michael D Lazarus, Zeping Wang, Michael R Yeaman, Aaron P Mitchell, Scott G Filler   +10 more
doaj   +1 more source

Candidalysin is a fungal peptide toxin critical for mucosal infection [PDF]

Nature, 2016
Published by Macmillan28177 ...
Moyes, David L.; id_orcid 0000-0002-1657-918X, Wilson, Duncan, Richardson, Jonathan P.; id_orcid 0000-0001-9638-2725, Mogavero, Selene, Tang, Shirley X., Wernecke, Julia, Hofs, Sarah, Gratacap, Remi L, Robbins, Jon, Runglall, Manohursingh, Murciano, Celia, Blagojevic, Mariana, Thavaraj, Selvam, Forster, Toni M, Hebecker, Betty, Kasper, Lydia, Vizcay-Barrena, Gema, Iancu, Simona I., Kichik, Nessim, Hader, Antje, Kurzai, Oliver, Luo, Ting, Kruger, Thomas, Kniemeyer, Olaf, Cota, Ernesto, Bader, Oliver, Bader, Oliver, Wheeler, Robert T, Gutsmann, Thomas, Hube, Bernhard, Naglik, Julian R.; id_orcid 0000-0002-8072-7917   +30 more
openaire   +6 more sources

Candidalysin impedes the development of embryonic zebrafish (Danio rerio) [PDF]

, 2021
Abstract Candidalysin is a cytolytic peptide secreted by Candida albicans, an opportunistic human fungal pathogen that was widely spread in clinic and in the environment. However, its impacts on the development of aquatic organisms remain limited.
Jing Shen, JingCong Tan, Haochun Shi, Jie Zhou, Yanbin Zhao, Kun Zhang, Ning-Ning Liu, Hui Wang   +7 more
openaire   +1 more source

Dynamic expression of candidalysin facilitates oral colonization of Candida albicans in mice. [PDF]

Nat Microbiol
Abstract Candida albicans is a common fungal member of the human microbiota but can also cause infections via expression of virulence factors associated with the yeast-to-hyphae transition. The evolutionary selection pressure to retain these pathogenic traits for a commensal microorganism remains unclear.
Fróis-Martins R, Lagler J, Schille TB, Elshafee O, Martinez de San Vicente K, Mertens S, Stokmaier M, Kilb I, Sertour N, Bachellier-Bassi S, Mogavero S, Sanglard D, d'Enfert C, Hube B, LeibundGut-Landmann S.   +14 more
europepmc   +4 more sources

Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin

The EMBO Reports, 2023
Abstract The peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET‐like structures (NLS), which are more compact and less fibrous than ...
Lucas Unger, Samuel Skoluda, Emelie Backman, Borko Amulic, Fernando M Ponce‐Garcia, Chinelo NC Etiaba, Sujan Yellagunda, Renate Krüger, Horst von Bernuth, Johan Bylund, Bernhard Hube, Julian R Naglik, Constantin F Urban   +12 more
openaire   +5 more sources