Results 61 to 70 of about 1,341 (134)

Taste Dysfunction in Oral Candidiasis: Impact of Candida Carriage and Hyphal Presence

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Taste dysfunction is a common symptom of oral candidiasis; however, its underlying mechanisms remain unclear. Objectives This study aimed to determine whether Candida albicans carriage, particularly its hyphal phenotype, is associated with impaired taste sensitivity.
Younjung Park, Hyo‐Jung Jung, Sin Hye Hwang, Eunae Sandra Cho, Hyung‐Joon Ahn   +4 more
wiley   +1 more source

Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin. [PDF]

Candidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive.
Phan, Quynh, Filler, Scott, Miao, Jian, Peters, Brian, Schaefer, Katherine, Zhang, Fuming, Liu, Hong, Barrera, Francisco, Pyron, Robert, Linhardt, Robert, Yeaman, Michael, King, Gavin, Russell, Charles, Solis, Norma, Dordick, Jonathan, Lin, Jianfeng, Tashiro, Masato   +16 more
core   +1 more source

and candidalysin in inflammatory disorders and cancer

, 2021
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised ...
Jemima Ho, Kichik, Nessim, Naglik, Julian R.; id_orcid, Richardson, Jonathan P.; id_orcid, James S. Griffiths, Giorgio Camilli, Jonathan P. Richardson, Nessim Kichik, Julian R. Naglik, Ho, Jemima, Griffiths, James S., Camilli, Giorgio   +11 more
core   +1 more source

Candida albicans Cells Lacking AP‐2 Have Defective Hyphae and Are Avirulent Despite Increased Host Uptake and Intracellular Proliferation in Macrophages

Molecular Microbiology, Volume 125, Issue 1, Page 1-12, January 2026.
Mutation of exocytic cargo adapter apm4Δ/Δ results in reduced virulence of Candida albicans during infection despite promoting intracellular growth in macrophages. ABSTRACT Candida albicans is a commensal microbe and opportunistic human pathogen. Candida yeast are recognized and taken up by macrophages via phagocytosis.
Stella Christou, Shannon Evans, Harriet Knafler, Iwona Smaczynska‐de Rooij, Kathryn R. Ayscough, Simon A. Johnston   +5 more
wiley   +1 more source

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

mBio, 2018
Macrophages rely on phagosomal acidity to destroy engulfed microorganisms. To survive this hostile response, opportunistic fungi such as Candida albicans developed strategies to evade the acidic environment. C. albicans is polymorphic and able to convert
Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein   +4 more
doaj   +1 more source

Geniposide attenuates astrocyte pyroptosis in depression via long non‐coding RNA Six3os1‐mediated regulation of the miR‐511‐3p/COL9A3 axis and MAPK/NLRP3 signaling

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Geniposide ameliorates depressive‐like behaviors in CUMS mice through the lncRNA Six3os1/miR‐511‐3p/COL9A3 axis and MAPK/NLRP3 signaling pathway. Abstract Depression involves multifaceted molecular pathways, with astrocyte pyroptosis emerging as a critical contributor to neuroinflammation.
Tianyu Zou, Cheng Mei, Xiaoyu Liang, Xiaolong Shang, Guoxiang Duan   +4 more
wiley   +1 more source

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan, Yirui Hu, Ye Yang, Huikuan Chu   +3 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, Volume 599, Issue 22, Page 3208-3243, November 2025.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Candida albicans Enhances Protease Activity and Activates MyD88‐Dependent IL‐1β Production in Human Keratinocytes

Mycoses, Volume 68, Issue 11, November 2025.
ABSTRACT Background Atopic dermatitis (AD) is a common chronic skin disorder characterised by a highly inflamed local environment and elevated epidermal proteolytic activity. Changes in the skin mycobiome have been observed in this disease, specifically Candida albicans colonization positively correlating with AD severity, yet the mechanisms by which ...
Jingyi Wang, Neil A. R. Gow, Matthew G. Brewer   +2 more
wiley   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source