Results 61 to 70 of about 1,214 (146)

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

It Takes Two to Tango: How a Dysregulation of the Innate Immunity, Coupled With Candida Virulence, Triggers VVC Onset

Frontiers in Microbiology, 2021
Vulvovaginal candidiasis (VVC) is a symptomatic inflammation of the vagina mainly caused by C. albicans. Other species, such as C. parapsilosis, C. glabrata, C. tropicalis, and C. krusei, are mainly associated to the recurrent form of the disease (RVVC),
Andrea Ardizzoni, Robert T. Wheeler, Robert T. Wheeler, Eva Pericolini, Eva Pericolini   +4 more
doaj   +1 more source

Oral Microbiota: Findings, Classification, Clinical Significance, and Therapeutic Interventions for Human Systemic Diseases

iMetaMed, Volume 2, Issue 1, March 2026.
Oral microbiota: findings, classification, clinical significance, and therapeutic interventions for human systemic diseases ABSTRACT The oral microbiota is an ecological community of commensal, symbiotic, and pathogenic microorganisms that colonizes the oral cavity.
Miao Zhang, Meihang Du, Wenjiang Zhang, Renhuan Huang, Wanting Li, Tongqi Li, Junping Bai, Ning Zhang, Jungang Chen, Jing Zhou, Bing Wang, Liwei An, Hideaki Kagami, Yiming Zhang   +13 more
wiley   +1 more source

Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real‐Time PCR Assay

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Gut microbiota plays a key role in triggering various diseases. However, translocation studies focus on bacteria, neglecting fungal elements, while fungi seem also involved in triggering various diseases. Aim of this study was to assess whether fungal elements were able to translocate in patients with AUD (alcohol use disorder) and to verify ...
Nathalie Pansu, Pascal Drakulovski, Donika Krasteva, Virginie Bellet, Jean‐Philippe Lavigne, Catherine Dunyach‐Remy, Florian Salipante, Alex Yahiaoui‐Martinez, Hélène Donnadieu‐Rigole, Sébastien Bertout   +9 more
wiley   +1 more source

Research Progress in the Treatment of Vaginitis With Bioactive Compounds: Targeting of Vaginal Microflora

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Mechanism diagram of the effect of herbal medicine on vaginitis. Herbal medicines mainly combat vaginitis by (A) inhibiting bacteria, (B) inhibiting fungi, (C) acting on the cilia of Trichomonas, (D) inhibiting virus replication, (E) repairing the mucosa, (F) enhancing immunity, and (G) maintaining the microecological balance.
Yongming Li, Huiyu Liu, Ruihan Li, Rong Li, Jiaqi Liu   +4 more
wiley   +1 more source

Taste Dysfunction in Oral Candidiasis: Impact of Candida Carriage and Hyphal Presence

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Taste dysfunction is a common symptom of oral candidiasis; however, its underlying mechanisms remain unclear. Objectives This study aimed to determine whether Candida albicans carriage, particularly its hyphal phenotype, is associated with impaired taste sensitivity.
Younjung Park, Hyo‐Jung Jung, Sin Hye Hwang, Eunae Sandra Cho, Hyung‐Joon Ahn   +4 more
wiley   +1 more source

Candida albicans Cells Lacking AP‐2 Have Defective Hyphae and Are Avirulent Despite Increased Host Uptake and Intracellular Proliferation in Macrophages

Molecular Microbiology, Volume 125, Issue 1, Page 1-12, January 2026.
Mutation of exocytic cargo adapter apm4Δ/Δ results in reduced virulence of Candida albicans during infection despite promoting intracellular growth in macrophages. ABSTRACT Candida albicans is a commensal microbe and opportunistic human pathogen. Candida yeast are recognized and taken up by macrophages via phagocytosis.
Stella Christou, Shannon Evans, Harriet Knafler, Iwona Smaczynska‐de Rooij, Kathryn R. Ayscough, Simon A. Johnston   +5 more
wiley   +1 more source

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan, Yirui Hu, Ye Yang, Huikuan Chu   +3 more
wiley   +1 more source

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

mBio, 2018
Macrophages rely on phagosomal acidity to destroy engulfed microorganisms. To survive this hostile response, opportunistic fungi such as Candida albicans developed strategies to evade the acidic environment. C. albicans is polymorphic and able to convert
Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein   +4 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, Volume 599, Issue 22, Page 3208-3243, November 2025.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source