Results 71 to 80 of about 1,079 (138)

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target

Journal of Fungi, 2019
Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to the disease state associated with various microbial infections.
Sandeep Vellanki, Eun Young Huh, Stephen P. Saville, Soo Chan Lee   +3 more
doaj   +1 more source

Pathophysiological microenvironments in oral candidiasis

APMIS, Volume 132, Issue 12, Page 956-973, December 2024.
Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC.
Mette Rose Jørgensen
wiley   +1 more source

Cortactin: A major cellular target of viral, protozoal, and fungal pathogens

Molecular Microbiology, Volume 122, Issue 2, Page 165-183, August 2024.
Recent advances in research on various viral, protozoal, and fungal pathogens have deepened our understanding of microbial virulence strategies and human disease development. Cortactin, a key host protein involved in actin cytoskeletal dynamics, has emerged as crucial player in host–microbe interactions, with pathogens manipulating its expression and ...
Irshad Sharafutdinov, Barbara Friedrich, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer   +4 more
wiley   +1 more source

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

PLoS Pathogens
The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions.
Jakob L Sprague, Tim B Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L Priest, Antzela Tsavou, Gianni Panagiotou, Julian R Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube   +13 more
doaj   +1 more source

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Nature Communications, 2018
Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging
Lydia Kasper, Annika König, Paul-Albert Koenig, Mark S. Gresnigt, Johannes Westman, Rebecca A. Drummond, Michail S. Lionakis, Olaf Groß, Jürgen Ruland, Julian R. Naglik, Bernhard Hube   +10 more
doaj   +1 more source

Phenotypic and genotypic analysis of Candida albicans vaginal isolates reveals that ECE1 expression underpins pathogenicity

Infection and Immunity
Candida albicans is the leading cause of vulvovaginal candidiasis (VVC), yet the extent to which strain-level variation influences pathogenic mechanisms remains unclear.
Amirhossein Davari, Junyan Liu, Jabez P. Fortwendel, Arturo Luna-Tapia, David J. Lowes, Jian Miao, Hubertine M. E. Willems, Christian A. DeJarnette, Tracy L. Peters, Nasim Ahmadi, Surabhi Naik, Marc Swidergall, P. David Rogers, Jack D. Sobel, Glen E. Palmer, Brian M. Peters   +15 more
doaj   +1 more source

Membrane Activity of the Fungal Peptide Toxin Candidalysin [PDF]

Biophysical Journal, 2018
Christian Nehls, Julia Wernecke, Laura Paulowski, Mareike Lewke, Helena S. Fabritz, Julian R. Naglik, Bernhard Hube, Thomas Gutsmann   +7 more
openaire   +1 more source

The transcription factor Ahr1 governs the recruitment of neutrophils to the brain and clearance of Candida albicans during CNS infection

mBio
Candida albicans causes infections of the central nervous system in premature infants and people with primary immune deficiencies affecting the innate immune system.
Rohan S. Wakade, Norma V. Solis, Laura C. Ristow, Melanie Wellington, Scott G. Filler, Damian J. Krysan   +5 more
doaj   +1 more source

Detection of some virulence factors among Candida albicans isolated from patients and prevalence of candidalysin gene ECE1

مجلة بغداد للعلوم
Candida albicans is a common cause of respiratory infection and oral candidiasis in people; it is an opportunistic yeast pathogen and a major cause of morbidity and mortality in the immunocompromised persons and causes superficial infections of mucosal ...
Safaa A. S. Al-Qaysi, Sokayna R. M. AL-Rubaie AL-Rubaie   +1 more
doaj   +1 more source