Results 71 to 80 of about 1,628 (159)

Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome [PDF]

Antimicrobial Agents and Chemotherapy, 2020
Repurposing of currently approved medications is an attractive option for the development of novel treatment strategies against physiological and infectious diseases. The antidiabetic sulfonylurea glyburide has demonstrated off-target capacity to inhibit activation of the NLRP3 inflammasome in a variety of disease models, including vaginal
David J, Lowes, Kirk E, Hevener, Brian M, Peters   +2 more
openaire   +2 more sources

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

mBio, 2018
Macrophages rely on phagosomal acidity to destroy engulfed microorganisms. To survive this hostile response, opportunistic fungi such as Candida albicans developed strategies to evade the acidic environment. C. albicans is polymorphic and able to convert
Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein   +4 more
doaj   +1 more source

Candida albicans Cells Lacking AP‐2 Have Defective Hyphae and Are Avirulent Despite Increased Host Uptake and Intracellular Proliferation in Macrophages

Molecular Microbiology, Volume 125, Issue 1, Page 1-12, January 2026.
Mutation of exocytic cargo adapter apm4Δ/Δ results in reduced virulence of Candida albicans during infection despite promoting intracellular growth in macrophages. ABSTRACT Candida albicans is a commensal microbe and opportunistic human pathogen. Candida yeast are recognized and taken up by macrophages via phagocytosis.
Stella Christou, Shannon Evans, Harriet Knafler, Iwona Smaczynska‐de Rooij, Kathryn R. Ayscough, Simon A. Johnston   +5 more
wiley   +1 more source

Candidalysin: Connecting the pore forming mechanism of this virulence factor to its immunostimulatory properties

Journal of Biological Chemistry, 2023
Candida albicans is a deadly pathogen responsible for millions of mucosal and systemic infections per year. The pathobiology of C. albicans is largely dependent on the damaging and immunostimulatory properties of the peptide candidalysin (CL), a key virulence factor.
Charles M. Russell, Jennifer A. Rybak, Jian Miao, Brian M. Peters, Francisco N. Barrera   +4 more
openaire   +2 more sources

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan, Yirui Hu, Ye Yang, Huikuan Chu   +3 more
wiley   +1 more source

Anti-Candida and Anti-Inflammatory Properties of a Vaginal Gel Formulation: Novel Data Concerning Vaginal Infection and Dysbiosis [PDF]

, 2023
Vaginal ecosystem is a unique environment where, in physiological conditions, lactobacilli dominate. However, pathogenic microbial species responsible for vaginitis and vaginosis can also harbor vaginal microbiota. To extend the data published by De Seta
Andrea Ardizzoni, Caterina A. Squartini Ramos, Elisabetta Blasi, Eva Pericolini, Francesco De Seta, Gianfranco B. Squartini Ramos, Luca Spaggiari, Natalia Pedretti   +7 more
core   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, Volume 599, Issue 22, Page 3208-3243, November 2025.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Polymerization mechanism of the Candida albicans virulence factor candidalysin

Journal of Biological Chemistry
Candida albicans is a commensal fungus that can cause epithelial infections and life-threatening invasive candidiasis. The fungus secretes candidalysin (CL), a peptide that causes cell damage and immune activation by permeation of epithelial membranes. The mechanism of CL action involves strong peptide assembly into polymers in solution.
Katherine G. Schaefer, Charles M. Russell, Robert J. Pyron, Elizabeth A. Conley, Francisco N. Barrera, Gavin M. King   +5 more
openaire   +2 more sources

Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Indian Journal of Dental Research
Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).
Mani B. Subramani, Krishnan Mahalakshmi, Bharathy Jaya, Sankar Leena Sankari, Venkatesan N. Kumar   +4 more
doaj   +1 more source

Candida albicans Enhances Protease Activity and Activates MyD88‐Dependent IL‐1β Production in Human Keratinocytes

Mycoses, Volume 68, Issue 11, November 2025.
ABSTRACT Background Atopic dermatitis (AD) is a common chronic skin disorder characterised by a highly inflamed local environment and elevated epidermal proteolytic activity. Changes in the skin mycobiome have been observed in this disease, specifically Candida albicans colonization positively correlating with AD severity, yet the mechanisms by which ...
Jingyi Wang, Neil A. R. Gow, Matthew G. Brewer   +2 more
wiley   +1 more source