Results 71 to 80 of about 1,214 (146)

Polymerization mechanism of the Candida albicans virulence factor candidalysin

Journal of Biological Chemistry
Candida albicans is a commensal fungus that can cause epithelial infections and life-threatening invasive candidiasis. The fungus secretes candidalysin (CL), a peptide that causes cell damage and immune activation by permeation of epithelial membranes. The mechanism of CL action involves strong peptide assembly into polymers in solution.
Katherine G. Schaefer, Charles M. Russell, Robert J. Pyron, Elizabeth A. Conley, Francisco N. Barrera, Gavin M. King   +5 more
openaire   +2 more sources

Candida albicans Enhances Protease Activity and Activates MyD88‐Dependent IL‐1β Production in Human Keratinocytes

Mycoses, Volume 68, Issue 11, November 2025.
ABSTRACT Background Atopic dermatitis (AD) is a common chronic skin disorder characterised by a highly inflamed local environment and elevated epidermal proteolytic activity. Changes in the skin mycobiome have been observed in this disease, specifically Candida albicans colonization positively correlating with AD severity, yet the mechanisms by which ...
Jingyi Wang, Neil A. R. Gow, Matthew G. Brewer   +2 more
wiley   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva, Laís de Souza Lacerda, Andrea de Souza Andrioli, Wilson Rodrigues Braz, Lara Melo Campos, Mayara Rodrigues Brandão de Paiva, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares   +8 more
wiley   +1 more source

Gut non-bacterial microbiota contributing to alcohol-associated liver disease

Gut Microbes, 2021
Intestinal microbiota, dominated by bacteria, plays an important role in the occurrence and the development of alcohol-associated liver disease (ALD), which is one of the most common liver diseases around the world.
Wenkang Gao, Yixin Zhu, Jin Ye, Huikuan Chu   +3 more
doaj   +1 more source

Filamentation Profiling Reveals Multiple Transcription Regulators Contributing to the Differences Between Candida albicans and Candida dubliniensis

Molecular Microbiology, Volume 124, Issue 4, Page 327-341, October 2025.
Candida albicans is a major fungal pathogen whose virulence is linked to filamentation. Its close relative, C. dubliniensis, filaments less efficiently and causes disease more rarely. To explore regulatory differences, we created C. dubliniensis mutants lacking transcription regulator orthologs that have been associated with filamentation in C ...
Teresa Meza‐Davalos, Luis F. García‐Ortega, Eugenio Mancera   +2 more
wiley   +1 more source

SC5314- and 529L-like candidalysin sequences reveal respective conserved ECE1 P2 sequences.

, 2021
(A)ECE1 sequence data from S1 Table (n = 78 isolates) was analyzed using WebLogo software to generate a graphical representation of amino acids across ECE1 P2 and P3 sequences from strains with SC5314- and 529L-like candidalysin sequences.
Andrew C. Dixson (11419367), Francisco N. Barrera (556833), Junyan Liu (4669801), Helene Tournu (3713263), Glen E. Palmer (3713260), Stefanie Allert (557903), Jian Miao (6410987), Julian R. Naglik (116049), Hubertine M. E. Willems (11419364), Emily A. Sansevere (6738779), Jonathan P. Richardson (615494), Bernhard Hube (108571), David J. Lowes (2148166), Zhenbo Xu (392294), Katherine S. Barker (5063831), Christian DeJarnette (6738776), Brian M. Peters (11250842)   +16 more
core   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin [PDF]

, 2017
Candidalysin, a hypha-associated fungal peptide, drives interleukin-17 responses to Candida albicans .
Sarah L. Gaffen, Partha S. Biswas, Kritika Ramani, Ramani, Kritika, Gaffen, Sarah L., Mufazalov, Ilgiz A., Coleman, Bianca M., Waisman, Ari, McGeachy, Mandy J., Chunsheng Zhou, Richardson, Jonathan P.; id_orcid, Anna R. Huppler, Julian R. Naglik, Verma, Akash H., Ari Waisman, Jemima Ho, Kane, Lawrence P., Ilgiz A. Mufazalov, Lawrence P. Kane, Huppler, Anna R., Akash H. Verma, Jonathan P. Richardson, Bianca M. Coleman, David L. Moyes, Zhou, Chunsheng, Bernhard Hube, Biswas, Partha S., Hube, Bernhard, Mandy J. McGeachy, Moyes, David L. ; id_orcid, Naglik, Julian R; id_orcid, Ho, Jemima   +31 more
core   +1 more source

Solubility of the synthetic candidalysin peptide.

, 2022
A: Amino acid sequence, putative tertiary structure, GRAVY index score, and hydropathy plot with Kyte-Doolittle scale of candidalysin (left) and Ece1-II (right). A positive hydropathy score reflects an enrichment of hydrophobic amino acids.
Hideo Kataoka (8727420), Taiki Mori (387896), Takeshi Into (563411), Gen Tanabe (13531747)   +3 more
core   +1 more source