Results 71 to 80 of about 1,341 (134)

SC5314- and 529L-like candidalysin sequences reveal respective conserved ECE1 P2 sequences.

, 2021
(A)ECE1 sequence data from S1 Table (n = 78 isolates) was analyzed using WebLogo software to generate a graphical representation of amino acids across ECE1 P2 and P3 sequences from strains with SC5314- and 529L-like candidalysin sequences.
Andrew C. Dixson (11419367), Francisco N. Barrera (556833), Junyan Liu (4669801), Helene Tournu (3713263), Glen E. Palmer (3713260), Stefanie Allert (557903), Jian Miao (6410987), Julian R. Naglik (116049), Hubertine M. E. Willems (11419364), Emily A. Sansevere (6738779), Jonathan P. Richardson (615494), Bernhard Hube (108571), David J. Lowes (2148166), Zhenbo Xu (392294), Katherine S. Barker (5063831), Christian DeJarnette (6738776), Brian M. Peters (11250842)   +16 more
core   +1 more source

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva, Laís de Souza Lacerda, Andrea de Souza Andrioli, Wilson Rodrigues Braz, Lara Melo Campos, Mayara Rodrigues Brandão de Paiva, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares   +8 more
wiley   +1 more source

Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin [PDF]

, 2017
Candidalysin, a hypha-associated fungal peptide, drives interleukin-17 responses to Candida albicans .
Sarah L. Gaffen, Partha S. Biswas, Kritika Ramani, Ramani, Kritika, Gaffen, Sarah L., Mufazalov, Ilgiz A., Coleman, Bianca M., Waisman, Ari, McGeachy, Mandy J., Chunsheng Zhou, Richardson, Jonathan P.; id_orcid, Anna R. Huppler, Julian R. Naglik, Verma, Akash H., Ari Waisman, Jemima Ho, Kane, Lawrence P., Ilgiz A. Mufazalov, Lawrence P. Kane, Huppler, Anna R., Akash H. Verma, Jonathan P. Richardson, Bianca M. Coleman, David L. Moyes, Zhou, Chunsheng, Bernhard Hube, Biswas, Partha S., Hube, Bernhard, Mandy J. McGeachy, Moyes, David L. ; id_orcid, Naglik, Julian R; id_orcid, Ho, Jemima   +31 more
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Filamentation Profiling Reveals Multiple Transcription Regulators Contributing to the Differences Between Candida albicans and Candida dubliniensis

Molecular Microbiology, Volume 124, Issue 4, Page 327-341, October 2025.
Candida albicans is a major fungal pathogen whose virulence is linked to filamentation. Its close relative, C. dubliniensis, filaments less efficiently and causes disease more rarely. To explore regulatory differences, we created C. dubliniensis mutants lacking transcription regulator orthologs that have been associated with filamentation in C ...
Teresa Meza‐Davalos, Luis F. García‐Ortega, Eugenio Mancera   +2 more
wiley   +1 more source

(related to Fig 6): Inhibiting MEK-ERK signaling suppresses C. albicans-induced cathelicidin production by pAds and candidalysin may not be the key driver of FGFR-mediated cathelicidin production in pAds.

, 2023
(A) U0126 application attenuated Camp mRNA expression in pAds stimulated with β-glucan for 12 h. (B) Mouse pAds were pretreated with U0126, AZD4547 or vehicle control (DMSO) for 2 h and then stimulated with PBS control (Ctrl) or β-glucan for 4 h. Western
Qian Yao (1451017), Min Li (12799), Rong Zeng (54019), Ling-juan Zhang (110382), Zhimin Duan (11795345), Weizhao Liu (17507399), Lu Yang (30847), Yiman Liu (603044), Xu Chen (432759), Jianing Wang (465119)   +9 more
core   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Solubility of the synthetic candidalysin peptide.

, 2022
A: Amino acid sequence, putative tertiary structure, GRAVY index score, and hydropathy plot with Kyte-Doolittle scale of candidalysin (left) and Ece1-II (right). A positive hydropathy score reflects an enrichment of hydrophobic amino acids.
Hideo Kataoka (8727420), Taiki Mori (387896), Takeshi Into (563411), Gen Tanabe (13531747)   +3 more
core   +1 more source

Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target

Journal of Fungi, 2019
Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to the disease state associated with various microbial infections.
Sandeep Vellanki, Eun Young Huh, Stephen P. Saville, Soo Chan Lee   +3 more
doaj   +1 more source

Pathogenicity of the cytotoxic toxin candidalysin produced by the hyphal form Candida albicans [PDF]

カンジダリシン（candidalysin）はカンジダ菌（Candida albicans）から産生される強い細胞傷害活性を有するぺプチド毒素である。カンジダリシンは菌糸型形態のC. albicansのみから産生され、C. albicansの宿主への感染局面において上皮バリアを突破する際に上皮細胞に対する細胞傷害活性を発揮する。あるいはC.
12715, 花岡, 麻里子, 16143, 9000004727967, 17262, 引頭, 毅, 森, 大気, 10360918, 17261, 堂前, 英資   +9 more
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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences

The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candidalysin and ...
Brakhage, Axel a., Zarnowski, Robert, Andes, David, Richardson, Jonathan p.; id_orcid, Richardson, Jonathan, D’enfert, Christophe, Blango, Matthew g., Kniemeyer, Olaf, Kasper, Lydia, Blango, Matthew, Handrianz, Tom, Priest, Emily l., Allert, Stefanie, Visser, Corissa, Himmel, Maximilian, Mogavero, Selene, König, Annika, Krüger, Thomas, Gutsmann, Thomas, Nehls, Christian, Lee, Sejeong, Yildirim, Deniz, Bougnoux, Marie-Elisabeth, Andes, David r., Naglik, Julian, Müller, Rita, Maufrais, Corinne, Naglik, Julian r.; id_orcid, Brakhage, Axel, Groth, Sabrina, Trümper, Verena, Hube, Bernhard, Priest, Emily   +32 more
core   +1 more source