Results 91 to 100 of about 1,214 (146)

The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent

mSphere
Candida albicans is one of the most common causes of superficial and invasive fungal diseases in humans. Its ability to cause disease is closely linked to its ability to undergo a morphological transition from budding yeast to filamentous forms (hyphae ...
Rohan S. Wakade, Melanie Wellington, Damian J. Krysan   +2 more
doaj   +1 more source

Development of CRISPR-cas9 ribonucleoprotein complex platform for disruption of candidalysin in Candida albicans

, 2020
The ECE1 gene encodes the ECE1 protein, which is processed into the toxic peptide, candidalysin in Candida albicans. Candidalysin is responsible for host epithelial cell damage and activation of the host cell inflammasome pathway during C.
Arzmi, Mohd Hafiz, Ramzi, Ahmad Bazli, Ahmad, Hasna   +2 more
core  

TREM2 Recognition of Candidalysin Orchestrates Mucosal Immunity in Oropharyngeal Candidiasis

Abstract The landscape of oral mucosal immunity, particularly in the context of oropharyngeal candidiasis (OPC), remains largely uncharted. By employing single-cell RNA sequencing (scRNA-seq) on murine models of OPC, we have illuminated the immune dynamics within this niche.
Weiwei Deng, Yishan Chen, Siqi Liu, Kefan Lin, Kai Zhang, Di Wang, Zhiying Yu, Weijia Zhao, Yingping Xu, Xiaowen Wang, Bin Yang, Ruoyu Li, Yunsheng Liang   +12 more
openaire   +1 more source

Identification of Candidalysin: a Candida albicans peptide toxin involved in epithelial damage [PDF]

, 2016
Normally a harmless coloniser of the skin and mucosal surfaces, Candida albicans can cause serious disease. The morphological switch from a budding yeast to a hyphal growth form is considered as one of the most important virulence traits, as hyphae ...
Höfs, Sarah
core  

Candidalysin promotes fungal-specific Th17 CD4 T cell differentiation and protective systemic immunogenicity. [PDF]

Mucosal Immunol
Nguyen NNM, Brady AE, Haslam DB, Frazer C, Pham G, Bennett RJ, Way SS.   +6 more
europepmc   +1 more source

Characterizing the novel pore formation mechanism of the Candida albicans virulence factor candidalysin

Fungal infections infect millions of people per year. The most common cause is the normally commensal fungus Candida albicans. Typically a harmless member of our microbiome, C.
Russell, Charles M, II
core  

The role and possible mechanism of intestinal fungi in the progression of chronic liver diseases. [PDF]

NPJ Biofilms Microbiomes
Hu Y, Yang Y, Wang S, Chu H.
europepmc   +1 more source

Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt. [PDF]

Sci Adv
Pellon A, Sadeghi Nasab SD, Bidkhori G, Griffiths JS, Vaga S, Begum N, Blagojevic M, Sigh NK, Kotowicz NK, Uzochukwu I, Le Guennec A, Henley-Smith R, Gregson-Williams H, Clasen F, Pryce M, Karimpour N, Cook R, Anguita J, Richardson JP, Thavaraj S, Naglik JR, Shoaie S, Moyes DL.   +22 more
europepmc   +1 more source

Critical parameters of fungal pathogenicity at the epithelial interphase. [PDF]

Microlife
Möslinger A, Allert S, Vylkova S, Hube B.   +3 more
europepmc   +1 more source

Induction of IκBζ augments cytokine production by candidalysin in oral epithelial cells

Journal of Osaka Dental University, 2023
DOMAE, Eisuke, YOSHIKAWA, Yoshihiro, KAMADA, Aiko, IKEO, Takashi   +3 more
openaire   +1 more source