Results 111 to 120 of about 1,079 (138)

Cytosolic receptors and signaling in antifungal immunity. [PDF]

EMBO J
Khau S, Desoubeaux G, Si-Tahar M, Biquand E, Briard B.   +4 more
europepmc   +1 more source

Concordance between different methods of detecting fungal-specific IgE antibody in asthma. [PDF]

Front Allergy
Shifani N, Denning DW.
europepmc   +1 more source

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Heparin interacts with candidalysin and neutralizes its cytotoxicity to oral epithelial cells

Journal of Oral Biosciences, 2023
Candidalysin is a peptide toxin produced by Candida albicans that causes damage to epithelial cells by destabilizing the plasma membrane. This study aimed to evaluate heparin's ability to neutralize candidalysin and protect epithelial cells from lysis.The study was conducted using a human oral epithelial cell line and synthetic candidalysin.
Eisuke Domae, Takashi Ikeo, Yoshihiro Yoshikawa   +2 more
exaly   +3 more sources

Candidalysin: discovery and function in Candida albicans infections

Current Opinion in Microbiology, 2019
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity.
Sarah Gaffen, Bernhard Hube, Julian Richard Naglik   +2 more
exaly   +4 more sources

Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa [PDF]

Infection and Immunity, 2018
ABSTRACT Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans , is a disease of immunocompetent and otherwise healthy women.
Saeed Shoaie, Jonathan Richardson, Brian Peters   +2 more
exaly   +4 more sources

In Vitro Biophysical Characterization of Candidalysin: A Fungal Peptide Toxin

2022
In 2016, the first peptide toxin in any human fungal pathogen was identified. It was discovered in Candida albicans and was named candidalysin. Candidalysin is an amphipathic cationic peptide that damages cell membranes. Like most lytic peptides, candidalysin shows alpha-helical secondary structure.
Lee, Sejeong, Kichik, Nessim, Hepworth, Olivia W., Richardson, Jonathan P., Naglik, Julian R.   +4 more
openaire   +3 more sources

Insights into the evolution of Candidalysin and recent developments

Archives of Microbiology
The alarming rise in fungal infections poses a serious health concern worldwide. Candida albicans is a highly virulent, ubiquitous opportunistic fungal pathogen associated with high mortality, particularly in immunocompromised individuals. Its infections range from superficial mucosal to invasive candidiasis. The pathogenicity of C. albicans is largely
Rekha Puria, Anil Thakur
exaly   +3 more sources

When platelets meet candidalysin: “We just Wnt to have fun”

Allergy: European Journal of Allergy and Clinical Immunology, 2022
Jorge Dominguez-Andres, Büsra Geçkin
exaly   +2 more sources

Candidalysin: An unlikely aide for fungal gut commensalism

Cell Host & Microbe
Fungi colonize the mammalian gastrointestinal (GI) tract and can adopt both commensal and opportunistic lifestyles. In a recent issue of Nature, Liang et al. unraveled the complex interplay between Candida morphotypes and the gut bacterial microbiota and described a key role for candidalysin in gut colonization.1.
Jesús A, Romo, Jose L, Lopez-Ribot
openaire   +2 more sources

Epithelial targets of Candidalysin

C57BL/6 or CD1 mice were administered vehicle (3% carboxymethylcelluose in PBS) gel or gel containing 5 mg/mL dextran sodium sulfate (DSS) 1 day prior to infection. They were then challenged intravaginally with 5x10^6 C. albicans followed by vehicle or DSS 2 h later, which continued daily throughout the study.
Miao, Jian, Peters, Brian
openaire   +1 more source