Results 131 to 140 of about 1,214 (146)

Insights into the evolution of Candidalysin and recent developments

Archives of Microbiology
The alarming rise in fungal infections poses a serious health concern worldwide. Candida albicans is a highly virulent, ubiquitous opportunistic fungal pathogen associated with high mortality, particularly in immunocompromised individuals. Its infections range from superficial mucosal to invasive candidiasis. The pathogenicity of C. albicans is largely
Anil Thakur, Rekha Puria
exaly   +3 more sources

When platelets meet candidalysin: “We just Wnt to have fun”

Allergy: European Journal of Allergy and Clinical Immunology, 2022
Özlem Bulut, Busranur Geçkin, Jorge Dominguez-Andres   +2 more
exaly   +2 more sources

Candidalysin: An unlikely aide for fungal gut commensalism

Cell Host & Microbe
Fungi colonize the mammalian gastrointestinal (GI) tract and can adopt both commensal and opportunistic lifestyles. In a recent issue of Nature, Liang et al. unraveled the complex interplay between Candida morphotypes and the gut bacterial microbiota and described a key role for candidalysin in gut colonization.1.
Jesús A, Romo, Jose L, Lopez-Ribot
openaire   +2 more sources

Epithelial targets of Candidalysin

C57BL/6 or CD1 mice were administered vehicle (3% carboxymethylcelluose in PBS) gel or gel containing 5 mg/mL dextran sodium sulfate (DSS) 1 day prior to infection. They were then challenged intravaginally with 5x10^6 C. albicans followed by vehicle or DSS 2 h later, which continued daily throughout the study.
Miao, Jian, Peters, Brian
openaire   +1 more source

The hyphal-specific toxin candidalysin promotes fungal gut commensalism

Nature
The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to adapt to its environment. The current dogma of C.
Shen-Huan Liang, Shabnam Sircaik, Joseph Dainis, Pallavi Kakade, Swathi Penumutchu, Liam D. McDonough, Ying-Han Chen, Corey Frazer, Tim B. Schille, Stefanie Allert, Osama Elshafee, Maria Hänel, Selene Mogavero, Shipra Vaishnava, Ken Cadwell, Peter Belenky, J. Christian Perez, Bernhard Hube, Iuliana V. Ene, Richard J. Bennett   +19 more
openaire   +3 more sources

Polymers of the candidalysin peptide become membrane pores

Biophysical Journal, 2023
Charles M. Russell, Katherine G. Schaefer, Andrew C. Dixson, Amber L.H. Gray, Robert J. Pyron, Ryan J. Schuck, Daiane S. Alves, Thanh Do, Gavin King, Francisco N. Barrera   +9 more
openaire   +1 more source

Candidalysin meets the kynurenine pathway: a tale of damage and regulation

Candida albicans is a commensal fungus that colonises the gastrointestinal tract and transitions from yeast to hyphal morphology during invasion. The hyphal form secretes candidalysin, which is a cytolytic peptide essential for disrupting epithelial barriers, invading tissue, and activating pro-inflammatory immune responses. The kynurenine pathway (KP)
openaire   +1 more source

Candidalysin Is the Hemolytic Factor of Candida albicans

Toxins, 2022
Selene Mogavero, Rita Müller, Sascha Brunke   +2 more
exaly  

Candidalysin, a Virulence Factor of Candida albicans, Stimulates Mast Cells by Mediating Cross-Talk Between Signaling Pathways Activated by the Dectin-1 Receptor and MAPKs

Journal of Clinical Immunology, 2022
Pu Song, Ge Peng, Takasuke Ogawa
exaly  

Candida albicans and candidalysin in inflammatory disorders and cancer

Immunology, 2021
Jemima Ho, Giorgio Camilli, James S Griffiths   +2 more
exaly