Results 121 to 130 of about 1,079 (138)

The hyphal-specific toxin candidalysin promotes fungal gut commensalism

Nature
The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to adapt to its environment. The current dogma of C.
Shen-Huan Liang, Shabnam Sircaik, Joseph Dainis, Pallavi Kakade, Swathi Penumutchu, Liam D. McDonough, Ying-Han Chen, Corey Frazer, Tim B. Schille, Stefanie Allert, Osama Elshafee, Maria Hänel, Selene Mogavero, Shipra Vaishnava, Ken Cadwell, Peter Belenky, J. Christian Perez, Bernhard Hube, Iuliana V. Ene, Richard J. Bennett   +19 more
openaire   +3 more sources

Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences

Nature Microbiology
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candidalysin and seven non-candidalysin Ece1 peptides (NCEPs), and is found to be conserved in clinical isolates. Here we
Müller, Rita, König, Annika, Groth, Sabrina, Zarnowski, Robert, Visser, Corissa, Handrianz, Tom, Maufrais, Corinne, Krüger, Thomas, Himmel, Maximilian, Lee, Sejeong, Priest, Emily, Yildirim, Deniz, Richardson, Jonathan, Blango, Matthew, Bougnoux, Marie-Elisabeth, Kniemeyer, Olaf, D’enfert, Christophe, Brakhage, Axel, Andes, David, Trümper, Verena, Nehls, Christian, Kasper, Lydia, Mogavero, Selene, Gutsmann, Thomas, Naglik, Julian, Allert, Stefanie, Hube, Bernhard   +26 more
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Polymers of the candidalysin peptide become membrane pores

Biophysical Journal, 2023
Charles M. Russell, Katherine G. Schaefer, Andrew C. Dixson, Amber L.H. Gray, Robert J. Pyron, Ryan J. Schuck, Daiane S. Alves, Thanh Do, Gavin King, Francisco N. Barrera   +9 more
openaire   +1 more source

Candidalysin meets the kynurenine pathway: a tale of damage and regulation

Candida albicans is a commensal fungus that colonises the gastrointestinal tract and transitions from yeast to hyphal morphology during invasion. The hyphal form secretes candidalysin, which is a cytolytic peptide essential for disrupting epithelial barriers, invading tissue, and activating pro-inflammatory immune responses. The kynurenine pathway (KP)
openaire   +1 more source

Candidalysin Is the Hemolytic Factor of Candida albicans

Toxins, 2022
Sascha Brunke, Bernhard Hube, Selene Mogavero   +2 more
exaly  

Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced byCandida albicans

Cellular Microbiology, 2021
Sascha Brunke, Thomas Krueger, Bernhard Hube   +2 more
exaly  

Candida albicans and candidalysin in inflammatory disorders and cancer

Immunology, 2021
Jonathan Richardson, Jemima Ho, Giorgio Camilli   +2 more
exaly  

The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence

Toxins, 2020
Lydia Kasper, Bernhard Hube, Hube Bernhard   +2 more
exaly  

Candidalysin, a Virulence Factor of Candida albicans, Stimulates Mast Cells by Mediating Cross-Talk Between Signaling Pathways Activated by the Dectin-1 Receptor and MAPKs

Journal of Clinical Immunology, 2022
Takasuke Ogawa, François Niyonsaba, Ge Peng   +2 more
exaly  

Effects of Candidalysin Derived from Candida albicans on the Expression of Pro-Inflammatory Mediators in Human Gingival Fibroblasts

International Journal of Molecular Sciences, 2023
Jun-Ichi Kido, Koji Naruishi, Hiromichi Yumoto   +2 more
exaly