Results 121 to 130 of about 1,214 (146)
Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease. [PDF]
World J GastroenterolPatnaik S +7 more
europepmc +1 more source
In Vitro Biophysical Characterization of Candidalysin: A Fungal Peptide Toxin
Methods in Molecular Biology, 2022 In 2016, the first peptide toxin in any human fungal pathogen was identified. It was discovered in Candida albicans and was named candidalysin. Candidalysin is an amphipathic cationic peptide that damages cell membranes. Like most lytic peptides, candidalysin shows alpha-helical secondary structure.
Sejeong Lee +2 more
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Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa [PDF]
Infection and Immunity, 2018 ABSTRACT Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans , is a disease of immunocompetent and otherwise healthy women.
Jonathan P Richardson +2 more
exaly +6 more sources
Candidalysin: discovery and function in Candida albicans infections
Current Opinion in Microbiology, 2019 Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity.
Julian R Naglik +2 more
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Cellular Microbiology, 2021 The human pathogenic fungus Candida albicans is a frequent cause of mucosal infections. Although the ability to transition from the yeast to the hypha morphology is essential for virulence, hypha formation and host cell invasion per se are not sufficient
Selene Mogavero +2 more
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The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis
Journal of Oral Pathology and Medicine, 2020 Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection.
Hasna Ahmad +2 more
exaly +2 more sources
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Heparin interacts with candidalysin and neutralizes its cytotoxicity to oral epithelial cells
Journal of Oral Biosciences, 2023Candidalysin is a peptide toxin produced by Candida albicans that causes damage to epithelial cells by destabilizing the plasma membrane. This study aimed to evaluate heparin's ability to neutralize candidalysin and protect epithelial cells from lysis.The study was conducted using a human oral epithelial cell line and synthetic candidalysin.
Eisuke Domae +2 more
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Journal of Biological Chemistry, 2022 Candida albicans (C. albicans) is a dimorphic commensal human fungal pathogen that can cause severe oropharyngeal candidiasis (oral thrush) in susceptible hosts. During invasive infection, C.
Nicole O Ponde +2 more
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Cell Reports, 2022 The egress of Candida hyphae from macrophages facilitates immune evasion, but it also alerts macrophages to infection and triggers inflammation. To better define the mechanisms, here we develop an imaging assay to directly and dynamically quantify hyphal
Françios A B Olivier +2 more
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Journal of Biological Chemistry, 2023 Candida albicans is a deadly pathogen responsible for millions of mucosal and systemic infections per year. The pathobiology of C. albicans is largely dependent on the damaging and immunostimulatory properties of the peptide candidalysin (CL), a key virulence factor.
Charles M Russell +2 more
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