Results 81 to 90 of about 1,214 (146)

Pathophysiological microenvironments in oral candidiasis

APMIS, Volume 132, Issue 12, Page 956-973, December 2024.
Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC.
Mette Rose Jørgensen
wiley   +1 more source

(related to Fig 6): Inhibiting MEK-ERK signaling suppresses C. albicans-induced cathelicidin production by pAds and candidalysin may not be the key driver of FGFR-mediated cathelicidin production in pAds.

, 2023
(A) U0126 application attenuated Camp mRNA expression in pAds stimulated with β-glucan for 12 h. (B) Mouse pAds were pretreated with U0126, AZD4547 or vehicle control (DMSO) for 2 h and then stimulated with PBS control (Ctrl) or β-glucan for 4 h. Western
Qian Yao (1451017), Min Li (12799), Rong Zeng (54019), Ling-juan Zhang (110382), Zhimin Duan (11795345), Weizhao Liu (17507399), Lu Yang (30847), Yiman Liu (603044), Xu Chen (432759), Jianing Wang (465119)   +9 more
core   +1 more source

Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target

Journal of Fungi, 2019
Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to the disease state associated with various microbial infections.
Sandeep Vellanki, Eun Young Huh, Stephen P. Saville, Soo Chan Lee   +3 more
doaj   +1 more source

Cortactin: A major cellular target of viral, protozoal, and fungal pathogens

Molecular Microbiology, Volume 122, Issue 2, Page 165-183, August 2024.
Recent advances in research on various viral, protozoal, and fungal pathogens have deepened our understanding of microbial virulence strategies and human disease development. Cortactin, a key host protein involved in actin cytoskeletal dynamics, has emerged as crucial player in host–microbe interactions, with pathogens manipulating its expression and ...
Irshad Sharafutdinov, Barbara Friedrich, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer   +4 more
wiley   +1 more source

Cross‐Sectional and Prospective Association of Serum 25‐Hydroxyvitamin D with Gut Mycobiota during Pregnancy among Women with Gestational Diabetes

Molecular Nutrition &Food Research, Volume 68, Issue 11, June 2024.
There is limited research conducted on the relationship between vitamin D and gut mycobiota. This study reveals that individuals with sufficient serum vitamin D exhibit a decreased abundance of fecal Saccharomyces. The results obtain from the vitamin D genetic risk score analysessupport this relationship.
Yuhui Liang, Zengliang Jiang, Yuanqing Fu, Sha Lu, Zelei Miao, Menglei Shuai, Xinxiu Liang, Wanglong Gou, Ke Zhang, Rui‐Qi Shi, Chang Gao, Mei‐Qi Shi, Xu‐Hong Wang, Wen‐Sheng Hu, Ju‐Sheng Zheng   +14 more
wiley   +1 more source

Digestive dynamics: Unveiling interplay between the gut microbiota and the liver in macronutrient metabolism and hepatic metabolic health

Physiological Reports, Volume 12, Issue 12, June 2024.
Abstract Although the liver is the largest metabolic organ in the body, it is not alone in functionality and is assisted by “an organ inside an organ,” the gut microbiota. This review attempts to shed light on the partnership between the liver and the gut microbiota in the metabolism of macronutrients (i.e., proteins, carbohydrates, and lipids).
Mrunmayee R. Kandalgaonkar, Virender Kumar, Matam Vijay‐Kumar   +2 more
wiley   +1 more source

Pathogenicity of the cytotoxic toxin candidalysin produced by the hyphal form Candida albicans [PDF]

カンジダリシン（candidalysin）はカンジダ菌（Candida albicans）から産生される強い細胞傷害活性を有するぺプチド毒素である。カンジダリシンは菌糸型形態のC. albicansのみから産生され、C. albicansの宿主への感染局面において上皮バリアを突破する際に上皮細胞に対する細胞傷害活性を発揮する。あるいはC.
12715, 花岡, 麻里子, 16143, 9000004727967, 17262, 引頭, 毅, 森, 大気, 10360918, 17261, 堂前, 英資   +9 more
core   +1 more source

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

PLoS Pathogens
The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions.
Jakob L Sprague, Tim B Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L Priest, Antzela Tsavou, Gianni Panagiotou, Julian R Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube   +13 more
doaj   +1 more source

Membrane Activity of the Fungal Peptide Toxin Candidalysin [PDF]

Biophysical Journal, 2018
Christian Nehls, Julia Wernecke, Laura Paulowski, Mareike Lewke, Helena S. Fabritz, Julian R. Naglik, Bernhard Hube, Thomas Gutsmann   +7 more
openaire   +1 more source

Detection of some virulence factors among Candida albicans isolated from patients and prevalence of candidalysin gene ECE1

مجلة بغداد للعلوم
Candida albicans is a common cause of respiratory infection and oral candidiasis in people; it is an opportunistic yeast pathogen and a major cause of morbidity and mortality in the immunocompromised persons and causes superficial infections of mucosal ...
Safaa A. S. Al-Qaysi, Sokayna R. M. AL-Rubaie AL-Rubaie   +1 more
doaj   +1 more source