Results 81 to 90 of about 1,341 (134)

Candidalysin is a fungal peptide toxin critical for mucosal infection [PDF]

, 2016
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses.
Naglik, Julian R.; id_orcid, Richardson, JP, Olaf Kniemeyer, Celia Murciano, Krueger, Thomas, Kasper, Lydia, Kurzai, O, Duncan Wilson, Ting Luo, Murciano, Celia, Gratacap, Remi L, Cota, Ernesto, Krüger, Thomas, Gema Vizcay, Häder, Antje, Gutsmann, T, Forster, Toni M, Wernecke, J, Hebecker, Betty, David L. Moyes, Runglall, M, Robert T. Wheeler, Bernhard Hube, Antje Häder, Betty Hebecker, Manohursingh Runglall, Selvam Thavaraj, Hoefs, S, Hebecker, B, Richardson, Jonathan P., Iancu, Simona I., Tang, SX, Foerster, TM, Kniemeyer, O, Toni M. Förster, Richardson, Jonathan P.; id_orcid, Hoefs, Sarah, Mogavero, Selene, Blagojevic, M, Gutsmann, Thomas, Förster, Toni M., Runglall, Manohursingh, Shirley X. Tang, Wheeler, Robert T., Julia Wernecke, Jonathan P. Richardson, Gratacap, RL, Thomas Krüger, Kichik, Nessim, Simona I. Iancu, Mogavero, S, Bader, O, Cota, E, Robbins, Jon, Sarah Höfs, Kniemeyer, Olaf, Bader, Oliver, Wheeler, Robert T, Kichik, N, Oliver Kurzai, Gratacap, Remi L., Naglik, Julian R., Tang, Shirley X., Murciano, C, Höfs, Sarah, Wernecke, Julia, Moyes, DL, Moyes, David L., Blagojevic, Mariana, Kasper, L, Oliver Bader, Hube, Bernhard, Thomas Gutsmann, Remi L. Gratacap, Moyes, David L.; id_orcid, Robbins, J, Kurzai, Oliver, Haeder, A, Jon Robbins, Haeder, Antje, Iancu, SI, Nessim Kichik, Vizcay-Barrena, Gema, Vizcay, G, Julian R. Naglik, Foerster, Toni M., Krueger, T, Thavaraj, Selvam, Ernesto Cota, Wheeler, RT, Hube, B, Luo, Ting, Lydia Kasper, Selene Mogavero, Wilson, Duncan, Luo, T, Wilson, D, Mariana Blagojevic, Vizcay, Gema, Thavaraj, S, Naglik, JR   +100 more
core   +1 more source

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

PLoS Pathogens
The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions.
Jakob L Sprague, Tim B Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L Priest, Antzela Tsavou, Gianni Panagiotou, Julian R Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube   +13 more
doaj   +1 more source

EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway

Virulence
Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson, Aize Pellon, Nicole O. Ponde, Olivia Hepworth, Lydia F. Daniels Gatward, Julian R. Naglik, David L. Moyes   +6 more
doaj   +1 more source

Detection of some virulence factors among Candida albicans isolated from patients and prevalence of candidalysin gene ECE1

مجلة بغداد للعلوم
Candida albicans is a common cause of respiratory infection and oral candidiasis in people; it is an opportunistic yeast pathogen and a major cause of morbidity and mortality in the immunocompromised persons and causes superficial infections of mucosal ...
Safaa A. S. Al-Qaysi, Sokayna R. M. AL-Rubaie AL-Rubaie   +1 more
doaj   +1 more source

Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis.

PLoS Pathogens
Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces.
Kuo-Yao Tseng, Yu-Tsung Huang, Yu-Ting Huang, Yu-Ting Su, An-Ni Wang, Wen-Yen Weng, Cai-Ling Ke, Yu-Chiao Yeh, Jhih-Jie Wang, Shin-Hei Du, Zi-Qi Gu, Wei-Lin Chen, Ching-Hsuan Lin, Yu-Huan Tsai   +13 more
doaj   +1 more source

Candidalysin:discovery and function in Candida albicans infections

, 2019
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and
Naglik, Julian R.; id_orcid, Hube, Bernhard, Gaffen, Sarah L.   +2 more
core   +1 more source

The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent

mSphere
Candida albicans is one of the most common causes of superficial and invasive fungal diseases in humans. Its ability to cause disease is closely linked to its ability to undergo a morphological transition from budding yeast to filamentous forms (hyphae ...
Rohan S. Wakade, Melanie Wellington, Damian J. Krysan   +2 more
doaj   +1 more source

Development of CRISPR-cas9 ribonucleoprotein complex platform for disruption of candidalysin in Candida albicans

, 2020
The ECE1 gene encodes the ECE1 protein, which is processed into the toxic peptide, candidalysin in Candida albicans. Candidalysin is responsible for host epithelial cell damage and activation of the host cell inflammasome pathway during C.
Arzmi, Mohd Hafiz, Ramzi, Ahmad Bazli, Ahmad, Hasna   +2 more
core  

Dangerous liaisons: Candidalysin and myeloid cells in candidiasis. [PDF]

PLoS Pathog
Gu ZQ, Chen YY, Tsai YH.
europepmc   +1 more source

Characterizing the novel pore formation mechanism of the Candida albicans virulence factor candidalysin

Fungal infections infect millions of people per year. The most common cause is the normally commensal fungus Candida albicans. Typically a harmless member of our microbiome, C.
Russell, Charles M, II
core