Results 81 to 90 of about 1,628 (159)

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis. [PDF]

PLoS Pathog
Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces. While efforts have been devoted to identifying microbial factors that modulate C.
Tseng KY, Huang YT, Huang YT, Su YT, Wang AN, Weng WY, Ke CL, Yeh YC, Wang JJ, Du SH, Gu ZQ, Chen WL, Lin CH, Tsai YH.   +13 more
europepmc   +3 more sources

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva, Laís de Souza Lacerda, Andrea de Souza Andrioli, Wilson Rodrigues Braz, Lara Melo Campos, Mayara Rodrigues Brandão de Paiva, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares   +8 more
wiley   +1 more source

Candida albicans-epithelial interactions and induction of mucosal innate immunity [PDF]

, 2017
Candida albicans is a human fungal pathogen that causes millions of mucosal and life-threatening infections annually.C. albicans initially interacts with epithelial cells, resulting in fungal recognition and the formation of hyphae.
Gaffen, Sarah, Hube, Bernhard, König, Annika, Naglik, Julian Richard   +3 more
core   +2 more sources

Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis [PDF]

, 2020
Oropharyngeal candidiasis (OPC; thrush) is an opportunistic infection caused by the commensal fungus Candida albicans Interleukin-17 (IL-17) and IL-22 are cytokines produced by type 17 lymphocytes.
Aggor, Felix E.Y., Bailey, Rachel D., Biswas, Partha S., Break, Timothy J., Bruno, Vincent M., Coleman, Bianca M., Durum, Scott K., Gaffen, Sarah L., Kaplan, Daniel H., Kolls, Jay K., Lionakis, Michail S., McCracken, Carrie, Naglik, Julian R., Shan, Wei, Shetty, Amol C., Trevejo-Nuñez, Giraldina, Whibley, Natasha   +16 more
core   +2 more sources

Filamentation Profiling Reveals Multiple Transcription Regulators Contributing to the Differences Between Candida albicans and Candida dubliniensis

Molecular Microbiology, Volume 124, Issue 4, Page 327-341, October 2025.
Candida albicans is a major fungal pathogen whose virulence is linked to filamentation. Its close relative, C. dubliniensis, filaments less efficiently and causes disease more rarely. To explore regulatory differences, we created C. dubliniensis mutants lacking transcription regulator orthologs that have been associated with filamentation in C ...
Teresa Meza‐Davalos, Luis F. García‐Ortega, Eugenio Mancera   +2 more
wiley   +1 more source

Gut non-bacterial microbiota contributing to alcohol-associated liver disease

Gut Microbes, 2021
Intestinal microbiota, dominated by bacteria, plays an important role in the occurrence and the development of alcohol-associated liver disease (ALD), which is one of the most common liver diseases around the world.
Wenkang Gao, Yixin Zhu, Jin Ye, Huikuan Chu   +3 more
doaj   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Ahr1-dependent regulation of ECE1 and other core filamentation response genes in Candida albicans [PDF]

, 2020
Candida albicans is a normally harmless commensal fungus and part of the human microbiota. However, in immunocompromised patients, C. albicans can cause diseases ranging from superficial infections to life threatening systemic infections.
Ruben, Sophia
core   +1 more source

Pathophysiological microenvironments in oral candidiasis

APMIS, Volume 132, Issue 12, Page 956-973, December 2024.
Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC.
Mette Rose Jørgensen
wiley   +1 more source