Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria. [PDF]
Front Immunol, 2022 Heterologous immunity, when the memory T cell response elicited by one pathogen recognizes another pathogen, has been offered as a contributing factor for the high variability in coronavirus disease 2019 (COVID-19) severity outcomes.
Eggenhuizen PJ +10 more
europepmc +2 more sources
Heterologous vaccine interventions: boosting immunity against future pandemics [PDF]
Molecular Medicine, 2021 While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens.
Daniela Marín-Hernández +2 more
doaj +3 more sources
Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections. [PDF]
Front Immunol, 2019 The central paradigm of vaccination is to generate resistance to infection by a specific pathogen when the vacinee is re-exposed to that pathogen. This paradigm is based on two fundamental characteristics of the adaptive immune system, specificity and ...
Agrawal B.
europepmc +2 more sources
Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis. [PDF]
J Infect Dis, 2019 AbstractDevelopment of an improved tuberculosis (TB) vaccine is a high worldwide public health priority. Bacillus Calmette-Guerin (BCG), the only licensed TB vaccine, provides variable efficacy against adult pulmonary TB, but why this protection varies is unclear.
Shah JA +4 more
europepmc +4 more sources
Vaccination and heterologous immunity: educating the immune system. [PDF]
Trans R Soc Trop Med Hyg, 2015 This review discusses three inter-related topics: (1) the immaturity of the neonatal and infant immune response; (2) heterologous immunity, where prior infection history with unrelated pathogens alters disease outcome resulting in either enhanced protective immunity or increased immunopathology to new infections, and (3) epidemiological human vaccine ...
Gil A +5 more
europepmc +5 more sources
Heterologous Immunity and Persistent Murine Cytomegalovirus Infection. [PDF]
J Virol, 2017 ABSTRACT One's history of infections can affect the immune response to unrelated pathogens and influence disease outcome through the process of heterologous immunity. This can occur after acute viral infections, such as infections with lymphocytic choriomeningitis virus (LCMV) and vaccinia virus, where the pathogens are cleared ...
Che JW, Daniels KA, Selin LK, Welsh RM.
europepmc +4 more sources
Unsolved Puzzles Surrounding HCV Immunity: Heterologous Immunity Adds Another Dimension. [PDF]
Int J Mol Sci, 2017 Chronic infection with hepatitis C virus (HCV) afflicts 3% of the world’s population and can lead to serious and late-stage liver diseases. Developing a vaccine for HCV is challenging because the correlates of protection are uncertain and traditional vaccine approaches do not work.
Agrawal B +5 more
europepmc +4 more sources
Heterologous immune responses in health and disease
Инфекция и иммунитет, 2020 Immunological memory and tolerance represent major achievements and advantages of adaptive immunity. Organisms bearing adaptive immunity display prominent competitive advantages in the fight against infections.
A. P. Toptygina
doaj +3 more sources
Cross reactive cellular immune responses in chickens previously exposed to low pathogenic avian influenza [PDF]
BMC Proceedings, 2011 Background Avian influenza (AI) infection in poultry can result in high morbidity and mortality, and negatively affect international trade. Because most AI vaccines used for poultry are inactivated, our knowledge of immunity against AI is based largely ...
Kapczynski Darrell R +5 more
doaj +2 more sources
Respiratory syncytial virus infection induces heterologous protection against SARS-CoV-2 through γδ T cell-mediated trained immunity and the activation of SARS-CoV-2-reactive mucosal T cells. [PDF]
J VirolRespiratory viruses can infect hosts concurrently or sequentially, potentially influencing each other’s pathogenic trajectory. However, the underlying immune mechanisms governing these interactions remain poorly understood.
Adam A +7 more
europepmc +2 more sources