Results 31 to 40 of about 49,719 (277)

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between <i>Plasmodium vivax</i> PvDBP and <i>Plasmodium falciparum</i> VAR2CSA. [PDF]

mBio, 2019
Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies.
Mitran CJ, Mena A, Gnidehou S, Banman S, Arango E, Lima BAS, Lugo H, Ganesan A, Salanti A, Mbonye AK, Ntumngia F, Barakat K, Adams JH, Kano FS, Carvalho LH, Maestre AE, Good MF, Yanow SK.   +17 more
europepmc   +2 more sources

Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung

EMBO Molecular Medicine, 2023
Bacillus Calmette‐Guérin (BCG) still remains the only licensed vaccine for TB and has been shown to provide nonspecific protection against unrelated pathogens.
Alisha Kang, Gluke Ye, Ramandeep Singh, Sam Afkhami, Jegarubee Bavananthasivam, Xiangqian Luo, Maryam Vaseghi‐Shanjani, Fatemah Aleithan, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing   +10 more
doaj   +1 more source

Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function [PDF]

, 2005
Background: Dendritic cells (DCs) are central to the initiation and regulation of the adaptive immune response during infection. Modulation of DC function may therefore allow evasion of the immune system by pathogens. Significant depression of the host'
Owain R Millington, R Phillips, Di Lorenzo, Caterina, Phillips, R. Stephen, Millington, Owain R., Paul Garside, Brewer, James M., Caterina Di Lorenzo, Garside, Paul, James M Brewer   +9 more
core   +1 more source

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants [PDF]

, 2021
The impact of initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting strain on downstream immunity to heterologous variants of concern (VOC) is unknown.
Butler, DK, COVIDsortium Immune Correlates Network‡, Moon, James C, Joy, G, Butler, David K, Moon, James C., Lin, Kai-Min, Boyton, Rosemary J., McKnight, Á, Joy, George, Menacho, Katia, Pade, C, Liu, Siyi, Kele, B, Altmann, Daniel M, Otter, Ashley, Kele, Beatrix, Pieper, Franziska, Maini, Mala K., Brooks, Tim, Fontana, M, Maini, MK, Treibel, Thomas A, Altmann, Daniel M., Smit, A, Sandoval, DM, Gibbons, Joseph M., Noursadeghi, M, Noursadeghi, Mahdad, Maini, Mala K, Butler, David K., Boyton, RJ, Otter, AD, Reynolds, CJ, Cutino-Moguel, Teresa, Liu, S, Manisty, C, Treibel, Thomas A., Gibbons, JM, McKnight, Áine, Sandoval, Diana Munoz, Reynolds, Catherine J., Gibbons, Joseph M, Moon, JC, Reynolds, Catherine J, Altmann, DM, Manisty, Charlotte, Pade, Corinna, Menacho, K, Brooks, T, Smit, Angelique, COVIDsortium Immune Correlates Network‡, ., Pieper, F, Treibel, TA, Fontana, Marianna, Semper, A, Boyton, Rosemary J, Semper, Amanda, Lin, K-M, Cutino-Moguel, T, Otter, Ashley D   +60 more
core   +1 more source

SPECIFIC HETEROLOGOUS ENHANCEMENT OF IMMUNE RESPONSES [PDF]

The Journal of Experimental Medicine, 1973
The mixing of two histoincompatible human lymphocyte cell lines generated the release of a soluble factor which was capable of nonspecifically enhancing the in vitro immune response of normal mouse spleen cells against sheep erythrocytes. When active supernates were subjected to exclusion chromatography on Sephadex G-150 and BioGel P-150, the active ...
Arnold S Rubin, A Bruce MacDonald, Albert H Coons   +2 more
openaire   +1 more source

A high force of Plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in Papua New Guinean children [PDF]

, 2013
When both parasite species are co-endemic, Plasmodium vivax incidence peaks in younger children compared to P. falciparum. To identify differences in the number of blood stage infections of these species and its potential link to acquisition of immunity,
Speed, Terence P., Ingrid Felger (92160), Kiniboro, B, Mueller Ivo, Kathryn L Colborn, Koepfli, Cristian, Terence P. Speed (132229), Speed Terence P., Koepfli, C, Cristian Koepfli, Felger Ingrid, Felger, Ingrid, Kiniboro, Benson, Terence P Speed, Kiniboro Benson, Ingrid Felger, Peter M. Siba (136849), Ivo Mueller (46609), Felger, I, Enmoore Lin, Lin Enmoore, Mueller, Ivo, Benson Kiniboro (191309), Ivo Mueller, Enmoore Lin (137888), Koepfli Cristian, Lin, Enmoore, Lin, E, Kathryn L. Colborn (454997), Colborn Kathryn L., Siba Peter M., Speed, TP, Mueller, I, Colborn, Kathryn L., Siba, PM, Siba, Peter M., Colborn, KL, Peter M Siba, Cristian Koepfli (191306), Benson Kiniboro   +39 more
core   +1 more source

Immunization with an autotransporter protein of Orientia tsutsugamushi provides protective immunity against scrub typhus. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi infection. Recently, the rapid increase of scrub typhus incidence in several countries within the endemic region has become a serious public health issue.
Na-Young Ha, Prashant Sharma, Gwanghun Kim, Yuri Kim, Chan-Ki Min, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho   +7 more
doaj   +1 more source

Heterologous immunity in the absence of variant-specific antibodies after exposure to subpatent infection with blood-stage malaria [PDF]

, 2005
We examined immunity induced by subpatent blood-stage malaria (undetectable by microscopy) using the rodent malaria parasite, Plasmodium chabaudi chabaudi, postulating that limited infection may allow expansion of antigen-specific T cells that are ...
Elliott, Salenna R., Kuns, Rachel D., Good, Michael F.   +2 more
core   +1 more source

Trained-immunity and cross-reactivity for protection: insights from the coronavirus disease 2019 and monkeypox emergencies for vaccine development

Exploration of Immunology, 2023
The emergence and re-emergence of pathogens is a public-health concern, which has become more evident after the coronavirus disease 2019 (COVID-19) pandemic and the monkeypox outbreaks in early 2022.
Amanda Izeli Portilho, Elizabeth De Gaspari   +1 more
doaj   +1 more source

Immune complex glomerulonephritis is induced in rats immunized with heterologous myeloperoxidase [PDF]

Clinical and Experimental Immunology, 1994
SUMMARY Anti-neutrophil cytoplasmic antibodies (ANCA), including anti-myeloperoxidase (MPO) antibodies, are associated with pauci-immune necrotizing small vessel vasculitis or glomerulonephritis, 1n order to substantiate a pathogenic role for ANCA, an animal model of pauci-immune ANCA-induced glomerulonephritis or vasculitis is required.
J J, Yang, J C, Jennette, R J, Falk
openaire   +2 more sources