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Heterologous immunity between viruses [PDF]
Immunological Reviews, 2010 Summary: Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity. This response can lead to enhanced or diminished protective immunity and altered immunopathology.
Welsh, Raymond M. +3 more
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Heterologous immunity meets tissue-specific training [PDF]
Nature Reviews Immunology, 2016 Tracy Hussell describes a 2003 study by Chen et al. that pioneered the concept of heterologous immunity.
Tracy Hussell
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Trends in Molecular Medicine, 2022 The innate immune system is able to build memory-like features in response to certain infections or vaccines, resulting in enhanced responsiveness upon (re)challenge with the same or an unrelated pathogen, a phenomenon termed 'trained immunity'. Compared with antigen-dependent adaptive immune responses triggered by classical vaccines against specific ...
Ziogas, A., Netea, M.G.
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Heterologous immunity: Immunopathology, autoimmunity and protection during viral infections [PDF]
Autoimmunity, 2011 Heterologous immunity is a common phenomenon present in all infections. Most of the time it is beneficial, mediating protective immunity, but in some individuals that have the wrong crossreactive response it leads to a cascade of events that result in severe immunopathology.
Selin, Liisa K. +6 more
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How to Employ Trained Immunity and Trained Immunity-Based Vaccines to Inhibit Allergic Inflammation. [PDF]
Vaccines (Basel)Trained immunity confers protection against subsequent unrelated infections through metabolic and epigenetic reprogramming. Unlike adaptive immunity, trained innate immunity provides broad, non-specific protection against diverse heterologous pathogens ...
Kim W, Jeoung D.
europepmc +2 more sources
HETEROLOGOUS IMMUNITY STUDIES IN CALVES IN IRAN [PDF]
Iranian Journal of Public Health, 1976 In a series of heterologous immunity studies S. haematobium, S. bovis and O. turkestanicum in calves, a large number of S. haematobium cercariae (21,000 cercariae) were used repeatedly as the immunization agent.
J. Massoud
doaj +3 more sources
Evaluation of non-reciprocal heterologous immunity between unrelated viruses. [PDF]
Virology, 2015 Heterologous immunity refers to the phenomenon whereby a history of an immune response against one pathogen can provide a level of immunity to a second unrelated pathogen. Previous investigations have shown that heterologous immunity is not necessarily reciprocal, such as in the case of vaccinia virus (VACV).
Che JW, Selin LK, Welsh RM.
europepmc +3 more sources
Broadening SARS-CoV-2 Immunity by Combining ORFV and Protein-Based Vaccines. [PDF]
Vaccines (Basel)Background: Emerging immune-evasive viral variants threaten the efficacy of current vaccines, underscoring the need for strategies that elicit broad and durable protection.
Reguzova A +4 more
europepmc +2 more sources
Editorial: Heterologous Immunity: Implications and Applications in Vaccines and Immunotherapies. [PDF]
Front Immunol, 2020 Singh S, Yanow SK, Agrawal B.
europepmc +2 more sources
Vaccines, 2023 With concerns about the efficacy of repeat annual influenza vaccination, it is important to better understand the impact of priming vaccine immunity and develop an effective vaccination strategy. Here, we determined the impact of heterologous prime-boost
Noopur Bhatnagar +8 more
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