Results 21 to 30 of about 49,719 (277)
Past Life and Future Effects—How Heterologous Infections Alter Immunity to Influenza Viruses
Frontiers in Immunology, 2018 Influenza virus frequently mutates due to its error-prone polymerase. This feature contributes to influenza virus’s ability to evade pre-existing immunity, leading to annual epidemics and periodic pandemics.
Aisha Souquette, Paul G. Thomas
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Respiratory syncytial virus infection induces heterologous protection against SARS-CoV-2 through γδ T cell-mediated trained immunity and the activation of SARS-CoV-2–reactive mucosal T cells [PDF]
Journal of VirologyRespiratory viruses can infect hosts concurrently or sequentially, potentially influencing each other’s pathogenic trajectory. However, the underlying immune mechanisms governing these interactions remain poorly understood.
Awadalkareem Adam +7 more
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VaccinesBackground/Objectives: Developing durable cellular immunity remains a critical challenge for HIV vaccine development. Methods: We evaluated a sequential and repeated heterologous prime–boost vaccination regimen using four distinct vector-based vaccines ...
Xiaozhou He +7 more
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Vaccines, 2023 With concerns about the efficacy of repeat annual influenza vaccination, it is important to better understand the impact of priming vaccine immunity and develop an effective vaccination strategy. Here, we determined the impact of heterologous prime-boost
Noopur Bhatnagar +8 more
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The Effects of Heterologous Immunization with Prime-Boost COVID-19 Vaccination against SARS-CoV-2
Vaccines, 2021 Coronavirus Disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the global challenge. Reaching global herd immunity will help end the COVID-19 pandemic.
Tzu-Chuan Ho +8 more
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Heterologous vaccine interventions: boosting immunity against future pandemics
Molecular Medicine, 2021 While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens.
Daniela Marín-Hernández +2 more
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Private aspects of heterologous immunity [PDF]
The Journal of Experimental Medicine, 2005 Clinical manifestations of viral infections are highly variable, both in type and severity, among individual patients. Differences in host genetics and in dose and route of infection contribute to this variability but do not fully explain it. New studies now show that each subject's history of past infections individualizes the memory T cell pool ...
Rehermann, B, Shin, EC Shin, Eui-Cheol
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Vaccines, 2023 (1) Background: As the COVID-19 pandemic enters its fourth year, it continues to cause significant morbidity and mortality worldwide. Although various vaccines have been approved and the use of homologous or heterologous boost doses is widely promoted ...
Dandan Li +9 more
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Diverse Routes of Allograft Tolerance Disruption by Memory T Cells
Frontiers in Immunology, 2020 Memory T lymphocytes constitute a significant problem in tissue and organ transplantation due their contribution to early rejection and their relative resistance to tolerance-promoting therapies.
Ronald G. Gill, Adam L. Burrack
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SPECIFIC HETEROLOGOUS ENHANCEMENT OF IMMUNE RESPONSES [PDF]
The Journal of Experimental Medicine, 1971 Abstract A soluble factor which enhanced the plaque-forming antibody response against sheep erythrocytes was found in tissue culture fluid of spleen cell cultures from mice injected with tetanus toxoid 1 to 2 months earlier to which 1 ng of toxoid was added on the 2nd day of a 5-day period of incubation. Such enhancement was demonstrated
Rubin, A S, Coons, A H
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