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Hybrid immunity strategies: heterologous vaccination combined with natural SARS-CoV-2 infection [PDF]

Frontiers in Medicine
The continuous evolution of SARS-CoV-2 poses a significant challenge to existing immune barriers, highlighting the limitations of single-modality immunization.
Yuan Huang, Xiaolu Zhang, Ruixia Miao, Jing Wang, Xuan Xi, Heng Pan, Yan Lu, Dehong Li   +7 more
doaj   +2 more sources

Cross-Protection in PRRSV: Mechanisms, Limitations, and Implications for Vaccine Design [PDF]

Pathogens
Porcine reproductive and respiratory syndrome (PRRS) remains one of the most economically devastating diseases in global swine production. The causative agent, PRRS virus (PRRSV), comprises two genetically distinct species—PRRSV-1 and PRRSV-2—that differ
Sergei A. Raev, Limeng Cai, Nina Muro, Rachel Madera, Lihua Wang, Jishu Shi   +5 more
doaj   +2 more sources

β-Glucan training induces stimulus-dependent immune and metabolic modulation in head kidney leukocytes that persists for several days in Atlantic salmon (Salmo salar L.) [PDF]

Frontiers in Immunology
The innate immune system of fish has conventionally been considered incapable of immunological memory, but is now being recognised as exhibiting memory-like features known as trained immunity.
Thinh Hoang Nhan, Thinh Hoang Nhan, Thinh Hoang Nhan, Lluis Tort, Carlo C. Lazado   +4 more
doaj   +2 more sources

Cross-protective immunity elicited by heterologous DNA prime/subunit or adenovirus boost regimens against bovine viral diarrhea virus [PDF]

BMC Veterinary Research
Bovine viral diarrhea (BVD) poses a substantial economic threat to the cattle industry, necessitating vaccines with broad cross-protective immunity. Heterologous prime-boost immunization represents a promising strategy to broaden immune protection by ...
Mingguo Xu, Xueyu Tao, Hengyun Gao, Hao Guo, Xiaoxiao Gu, Yuting Zhang, Jing Yuan, Honghuan Li, Yueli Wang, Jihai Yi, Jinliang Sheng, Ningning Yang, Huan Zhang, Chuangfu Chen   +13 more
doaj   +2 more sources

Respiratory syncytial virus infection induces heterologous protection against SARS-CoV-2 through γδ T cell-mediated trained immunity and the activation of SARS-CoV-2–reactive mucosal T cells [PDF]

Journal of Virology
Respiratory viruses can infect hosts concurrently or sequentially, potentially influencing each other’s pathogenic trajectory. However, the underlying immune mechanisms governing these interactions remain poorly understood.
Awadalkareem Adam, Wenzhe Wu, Madison C. Jones, Haiping Hao, Aditi, Parimal Samir, Xiaoyong Bao, Tian Wang   +7 more
doaj   +2 more sources

SphB1 export system for antigen presentation to the respiratory tract by a live pertussis vaccine [PDF]

Applied Microbiology and Biotechnology
BPZE1 is a live attenuated vaccine currently in advanced clinical development for nasal immunization against pertussis. The ability of this vaccine to induce mucosal and systemic, humoral and cellular immunity make it an attractive mucosal delivery ...
Lazara Elena Santiesteban-Lores, Dominique Raze, Violaine Dubois, Morgane Tardy, Anne-Sophie Debrie, Peter Goldstein, Loic Coutte, Camille Locht   +7 more
doaj   +2 more sources

Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria

Frontiers in Immunology, 2022
Heterologous immunity, when the memory T cell response elicited by one pathogen recognizes another pathogen, has been offered as a contributing factor for the high variability in coronavirus disease 2019 (COVID-19) severity outcomes.
Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Rachel M.Y. Cheong, Anusha Yellapragada, Wey Y. Wong, Yi Tian Ting, Julie A. Monk, Poh-Yi Gan, Poh-Yi Gan, Stephen R. Holdsworth, Stephen R. Holdsworth, Joshua D. Ooi   +12 more
doaj   +1 more source

Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination

Vaccines, 2023
With concerns about the efficacy of repeat annual influenza vaccination, it is important to better understand the impact of priming vaccine immunity and develop an effective vaccination strategy. Here, we determined the impact of heterologous prime-boost
Noopur Bhatnagar, Ki-Hye Kim, Jeeva Subbiah, Sakinah Muhammad-Worsham, Bo Ryoung Park, Rong Liu, Phillip Grovenstein, Bao-Zhong Wang, Sang-Moo Kang   +8 more
doaj   +1 more source

The Effects of Heterologous Immunization with Prime-Boost COVID-19 Vaccination against SARS-CoV-2

Vaccines, 2021
Coronavirus Disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the global challenge. Reaching global herd immunity will help end the COVID-19 pandemic.
Tzu-Chuan Ho, Yi-Ming Arthur Chen, Hung-Pin Chan, Chin-Chuan Chang, Kuo-Pin Chuang, Che-Hsin Lee, Cheng-Hui Yuan, Yu-Chang Tyan, Ming-Hui Yang   +8 more
doaj   +1 more source

Heterologous vaccine interventions: boosting immunity against future pandemics

Molecular Medicine, 2021
While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens.
Daniela Marín-Hernández, Douglas F. Nixon, Nathaniel Hupert   +2 more
doaj   +1 more source