Hybrid immunity strategies: heterologous vaccination combined with natural SARS-CoV-2 infection [PDF]
Frontiers in MedicineThe continuous evolution of SARS-CoV-2 poses a significant challenge to existing immune barriers, highlighting the limitations of single-modality immunization.
Yuan Huang +7 more
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Cross-Protection in PRRSV: Mechanisms, Limitations, and Implications for Vaccine Design [PDF]
PathogensPorcine reproductive and respiratory syndrome (PRRS) remains one of the most economically devastating diseases in global swine production. The causative agent, PRRS virus (PRRSV), comprises two genetically distinct species—PRRSV-1 and PRRSV-2—that differ
Sergei A. Raev +5 more
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β-Glucan training induces stimulus-dependent immune and metabolic modulation in head kidney leukocytes that persists for several days in Atlantic salmon (Salmo salar L.) [PDF]
Frontiers in ImmunologyThe innate immune system of fish has conventionally been considered incapable of immunological memory, but is now being recognised as exhibiting memory-like features known as trained immunity.
Thinh Hoang Nhan +4 more
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Cross-protective immunity elicited by heterologous DNA prime/subunit or adenovirus boost regimens against bovine viral diarrhea virus [PDF]
BMC Veterinary ResearchBovine viral diarrhea (BVD) poses a substantial economic threat to the cattle industry, necessitating vaccines with broad cross-protective immunity. Heterologous prime-boost immunization represents a promising strategy to broaden immune protection by ...
Mingguo Xu +13 more
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Heterologous immune responses in health and disease
Инфекция и иммунитет, 2020 Immunological memory and tolerance represent major achievements and advantages of adaptive immunity. Organisms bearing adaptive immunity display prominent competitive advantages in the fight against infections.
A. P. Toptygina
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Respiratory syncytial virus infection induces heterologous protection against SARS-CoV-2 through γδ T cell-mediated trained immunity and the activation of SARS-CoV-2–reactive mucosal T cells [PDF]
Journal of VirologyRespiratory viruses can infect hosts concurrently or sequentially, potentially influencing each other’s pathogenic trajectory. However, the underlying immune mechanisms governing these interactions remain poorly understood.
Awadalkareem Adam +7 more
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Homologous MVA and heterologous DREP/MVA vaccine regimens induce robust and durable immune responses against SARS-CoV-2 [PDF]
Scientific ReportsDespite the success of current COVID-19 vaccines, the immunity they generate wanes over time, requiring periodic boosters. The limited durability of memory responses, particularly from mRNA vaccines, remains a major challenge for achieving long-term ...
Patricia Pérez +7 more
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How to Employ Trained Immunity and Trained Immunity-Based Vaccines to Inhibit Allergic Inflammation [PDF]
VaccinesTrained immunity confers protection against subsequent unrelated infections through metabolic and epigenetic reprogramming. Unlike adaptive immunity, trained innate immunity provides broad, non-specific protection against diverse heterologous pathogens ...
Wonho Kim, Dooil Jeoung
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HETEROLOGOUS IMMUNITY STUDIES IN CALVES IN IRAN [PDF]
Iranian Journal of Public Health, 1976 In a series of heterologous immunity studies S. haematobium, S. bovis and O. turkestanicum in calves, a large number of S. haematobium cercariae (21,000 cercariae) were used repeatedly as the immunization agent.
J. Massoud
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Broadening SARS-CoV-2 Immunity by Combining ORFV and Protein-Based Vaccines [PDF]
VaccinesBackground: Emerging immune-evasive viral variants threaten the efficacy of current vaccines, underscoring the need for strategies that elicit broad and durable protection.
Alena Reguzova +4 more
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