Results 11 to 20 of about 49,620 (199)

Vaccination and heterologous immunity: educating the immune system [PDF]

Transactions of The Royal Society of Tropical Medicine and Hygiene, 2015
This review discusses three inter-related topics: (1) the immaturity of the neonatal and infant immune response; (2) heterologous immunity, where prior infection history with unrelated pathogens alters disease outcome resulting in either enhanced protective immunity or increased immunopathology to new infections, and (3) epidemiological human vaccine ...
Gil, Anna, Kenney, Laurie L., Mishra, Rabinarayan, Watkin, Levi B., Aslan, Nuray, Selin, Liisa K.   +5 more
openaire   +4 more sources

Heterologous effects of vaccination and trained immunity [PDF]

Clinical Microbiology and Infection, 2019
Vaccines are applied to large populations, but only recently has research into immunologic responses and mechanisms started to increase exponentially. Some live vaccines, such as the tuberculosis vaccine bacillus Calmette-Guérin, protect against other infections nonspecifically by eliciting complex immune responses which are not specific antibody ...
Gyssens, I.C.J., Netea, M.G., Netea, M.G.   +2 more
openaire   +4 more sources

In-depth analysis of T cell immunity and antibody responses in heterologous prime-boost-boost vaccine regimens against SARS-CoV-2 and Omicron variant [PDF]

Frontiers in Immunology, 2022
With the emergence of novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Variants of Concern (VOCs), vaccination studies that elucidate the efficiency and effectiveness of a vaccination campaign are critical to assess the durability and ...
Natalie Heinen, Corinna Sophie Marheinecke, Clara Bessen, Arturo Blazquez-Navarro, Arturo Blazquez-Navarro, Toralf Roch, Toralf Roch, Ulrik Stervbo, Moritz Anft, Carlos Plaza-Sirvent, Sandra Busse, Mara Klöhn, Jil Schrader, Elena Vidal Blanco, Doris Urlaub, Carsten Watzl, Markus Hoffmann, Stefan Pöhlmann, Matthias Tenbusch, Eike Steinmann, Daniel Todt, Daniel Todt, Carsten Hagenbeck, Gert Zimmer, Gert Zimmer, Wolfgang Ekkehard Schmidt, Daniel Robert Quast, Nina Babel, Nina Babel, Ingo Schmitz, Stephanie Pfänder   +30 more
doaj   +2 more sources

Past Life and Future Effects—How Heterologous Infections Alter Immunity to Influenza Viruses

Frontiers in Immunology, 2018
Influenza virus frequently mutates due to its error-prone polymerase. This feature contributes to influenza virus’s ability to evade pre-existing immunity, leading to annual epidemics and periodic pandemics.
Aisha Souquette, Paul G. Thomas
doaj   +2 more sources

Unsolved Puzzles Surrounding HCV Immunity: Heterologous Immunity Adds Another Dimension. [PDF]

Int J Mol Sci, 2017
Chronic infection with hepatitis C virus (HCV) afflicts 3% of the world’s population and can lead to serious and late-stage liver diseases. Developing a vaccine for HCV is challenging because the correlates of protection are uncertain and traditional ...
Agrawal B, Singh S, Gupta N, Li W, Vedi S, Kumar R.   +5 more
europepmc   +2 more sources

Decade-Long Sustained Cellular Immunity Induced by Sequential and Repeated Vaccination with Four Heterologous HIV Vaccines in Rhesus Macaques

Vaccines
Background/Objectives: Developing durable cellular immunity remains a critical challenge for HIV vaccine development. Methods: We evaluated a sequential and repeated heterologous prime–boost vaccination regimen using four distinct vector-based vaccines ...
Xiaozhou He, Danying Chen, Qi Ma, Yanzhe Hao, Hongxia Li, Xiaoguang Zhang, Yuxi Cao, Xia Feng   +7 more
doaj   +2 more sources

Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria

Frontiers in Immunology, 2022
Heterologous immunity, when the memory T cell response elicited by one pathogen recognizes another pathogen, has been offered as a contributing factor for the high variability in coronavirus disease 2019 (COVID-19) severity outcomes.
Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Rachel M.Y. Cheong, Anusha Yellapragada, Wey Y. Wong, Yi Tian Ting, Julie A. Monk, Poh-Yi Gan, Poh-Yi Gan, Stephen R. Holdsworth, Stephen R. Holdsworth, Joshua D. Ooi   +12 more
doaj   +1 more source

Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination

Vaccines, 2023
With concerns about the efficacy of repeat annual influenza vaccination, it is important to better understand the impact of priming vaccine immunity and develop an effective vaccination strategy. Here, we determined the impact of heterologous prime-boost
Noopur Bhatnagar, Ki-Hye Kim, Jeeva Subbiah, Sakinah Muhammad-Worsham, Bo Ryoung Park, Rong Liu, Phillip Grovenstein, Bao-Zhong Wang, Sang-Moo Kang   +8 more
doaj   +1 more source

The Effects of Heterologous Immunization with Prime-Boost COVID-19 Vaccination against SARS-CoV-2

Vaccines, 2021
Coronavirus Disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the global challenge. Reaching global herd immunity will help end the COVID-19 pandemic.
Tzu-Chuan Ho, Yi-Ming Arthur Chen, Hung-Pin Chan, Chin-Chuan Chang, Kuo-Pin Chuang, Che-Hsin Lee, Cheng-Hui Yuan, Yu-Chang Tyan, Ming-Hui Yang   +8 more
doaj   +1 more source

Heterologous immunity between viruses [PDF]

Immunological Reviews, 2010
Summary:  Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity. This response can lead to enhanced or diminished protective immunity and altered immunopathology.
Welsh, Raymond M., Che, Jenny Wun-Yue, Brehm, Michael A., Selin, Liisa K.   +3 more
openaire   +3 more sources