Results 21 to 30 of about 49,620 (199)

Heterologous vaccine interventions: boosting immunity against future pandemics

Molecular Medicine, 2021
While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens.
Daniela Marín-Hernández, Douglas F. Nixon, Nathaniel Hupert   +2 more
doaj   +1 more source

Private aspects of heterologous immunity [PDF]

The Journal of Experimental Medicine, 2005
Clinical manifestations of viral infections are highly variable, both in type and severity, among individual patients. Differences in host genetics and in dose and route of infection contribute to this variability but do not fully explain it. New studies now show that each subject's history of past infections individualizes the memory T cell pool ...
Rehermann, B, Shin, EC Shin, Eui-Cheol
openaire   +3 more sources

Long-Term Cross Immune Response in Mice following Heterologous Prime-Boost COVID-19 Vaccination with Full-Length Spike mRNA and Recombinant S1 Protein

Vaccines, 2023
(1) Background: As the COVID-19 pandemic enters its fourth year, it continues to cause significant morbidity and mortality worldwide. Although various vaccines have been approved and the use of homologous or heterologous boost doses is widely promoted ...
Dandan Li, Heng Zhao, Yun Liao, Guorun Jiang, Pingfang Cui, Ying Zhang, Li Yu, Shengtao Fan, Hangwen Li, Qihan Li   +9 more
doaj   +1 more source

Diverse Routes of Allograft Tolerance Disruption by Memory T Cells

Frontiers in Immunology, 2020
Memory T lymphocytes constitute a significant problem in tissue and organ transplantation due their contribution to early rejection and their relative resistance to tolerance-promoting therapies.
Ronald G. Gill, Adam L. Burrack
doaj   +1 more source

SPECIFIC HETEROLOGOUS ENHANCEMENT OF IMMUNE RESPONSES [PDF]

The Journal of Experimental Medicine, 1971
Abstract A soluble factor which enhanced the plaque-forming antibody response against sheep erythrocytes was found in tissue culture fluid of spleen cell cultures from mice injected with tetanus toxoid 1 to 2 months earlier to which 1 ng of toxoid was added on the 2nd day of a 5-day period of incubation. Such enhancement was demonstrated
Rubin, A S, Coons, A H
openaire   +4 more sources

Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung

EMBO Molecular Medicine, 2023
Bacillus Calmette‐Guérin (BCG) still remains the only licensed vaccine for TB and has been shown to provide nonspecific protection against unrelated pathogens.
Alisha Kang, Gluke Ye, Ramandeep Singh, Sam Afkhami, Jegarubee Bavananthasivam, Xiangqian Luo, Maryam Vaseghi‐Shanjani, Fatemah Aleithan, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing   +10 more
doaj   +1 more source

The impact of vaccines on heterologous adaptive immunity [PDF]

Clinical Microbiology and Infection, 2019
Vaccines induce antigen-specific memory in adaptive immune cells that enables long-lived protection against the target pathogen. In addition to this, several vaccines have beneficial effects greater than protection against their target pathogen. These non-specific effects are proposed to be the result of vaccine-induced immunomodulation. In the case of
N L, Messina, P, Zimmermann, N, Curtis
openaire   +2 more sources

Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function [PDF]

, 2005
Background: Dendritic cells (DCs) are central to the initiation and regulation of the adaptive immune response during infection. Modulation of DC function may therefore allow evasion of the immune system by pathogens. Significant depression of the host'
Owain R Millington, R Phillips, Di Lorenzo, Caterina, Phillips, R. Stephen, Millington, Owain R., Paul Garside, Brewer, James M., Caterina Di Lorenzo, Garside, Paul, James M Brewer   +9 more
core   +1 more source

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants [PDF]

, 2021
The impact of initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting strain on downstream immunity to heterologous variants of concern (VOC) is unknown.
Butler, DK, COVIDsortium Immune Correlates Network‡, Moon, James C, Joy, G, Butler, David K, Moon, James C., Lin, Kai-Min, Boyton, Rosemary J., McKnight, Á, Joy, George, Menacho, Katia, Pade, C, Liu, Siyi, Kele, B, Altmann, Daniel M, Otter, Ashley, Kele, Beatrix, Pieper, Franziska, Maini, Mala K., Brooks, Tim, Fontana, M, Maini, MK, Treibel, Thomas A, Altmann, Daniel M., Smit, A, Sandoval, DM, Gibbons, Joseph M., Noursadeghi, M, Noursadeghi, Mahdad, Maini, Mala K, Butler, David K., Boyton, RJ, Otter, AD, Reynolds, CJ, Cutino-Moguel, Teresa, Liu, S, Manisty, C, Treibel, Thomas A., Gibbons, JM, McKnight, Áine, Sandoval, Diana Munoz, Reynolds, Catherine J., Gibbons, Joseph M, Moon, JC, Reynolds, Catherine J, Altmann, DM, Manisty, Charlotte, Pade, Corinna, Menacho, K, Brooks, T, Smit, Angelique, COVIDsortium Immune Correlates Network‡, ., Pieper, F, Treibel, TA, Fontana, Marianna, Semper, A, Boyton, Rosemary J, Semper, Amanda, Lin, K-M, Cutino-Moguel, T, Otter, Ashley D   +60 more
core   +1 more source

SPECIFIC HETEROLOGOUS ENHANCEMENT OF IMMUNE RESPONSES [PDF]

The Journal of Experimental Medicine, 1973
The mixing of two histoincompatible human lymphocyte cell lines generated the release of a soluble factor which was capable of nonspecifically enhancing the in vitro immune response of normal mouse spleen cells against sheep erythrocytes. When active supernates were subjected to exclusion chromatography on Sephadex G-150 and BioGel P-150, the active ...
Arnold S Rubin, A Bruce MacDonald, Albert H Coons   +2 more
openaire   +1 more source