Results 21 to 30 of about 449,551 (293)

Diverse Routes of Allograft Tolerance Disruption by Memory T Cells

Frontiers in Immunology, 2020
Memory T lymphocytes constitute a significant problem in tissue and organ transplantation due their contribution to early rejection and their relative resistance to tolerance-promoting therapies.
Ronald G. Gill, Adam L. Burrack
doaj   +1 more source

SPECIFIC HETEROLOGOUS ENHANCEMENT OF IMMUNE RESPONSES [PDF]

The Journal of Experimental Medicine, 1971
Abstract A soluble factor which enhanced the plaque-forming antibody response against sheep erythrocytes was found in tissue culture fluid of spleen cell cultures from mice injected with tetanus toxoid 1 to 2 months earlier to which 1 ng of toxoid was added on the 2nd day of a 5-day period of incubation. Such enhancement was demonstrated
Rubin, A S, Coons, A H
openaire   +6 more sources

The impact of vaccines on heterologous adaptive immunity [PDF]

Clinical Microbiology and Infection, 2019
Vaccines induce antigen-specific memory in adaptive immune cells that enables long-lived protection against the target pathogen. In addition to this, several vaccines have beneficial effects greater than protection against their target pathogen. These non-specific effects are proposed to be the result of vaccine-induced immunomodulation. In the case of
N L, Messina, P, Zimmermann, N, Curtis
openaire   +2 more sources

Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung

EMBO Molecular Medicine, 2023
Bacillus Calmette‐Guérin (BCG) still remains the only licensed vaccine for TB and has been shown to provide nonspecific protection against unrelated pathogens.
Alisha Kang, Gluke Ye, Ramandeep Singh, Sam Afkhami, Jegarubee Bavananthasivam, Xiangqian Luo, Maryam Vaseghi‐Shanjani, Fatemah Aleithan, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing   +10 more
doaj   +1 more source

Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function [PDF]

, 2005
Background: Dendritic cells (DCs) are central to the initiation and regulation of the adaptive immune response during infection. Modulation of DC function may therefore allow evasion of the immune system by pathogens. Significant depression of the host'
Owain R Millington, R Phillips, Di Lorenzo, Caterina, Phillips, R. Stephen, Millington, Owain R., Paul Garside, Brewer, James M., Caterina Di Lorenzo, Garside, Paul, James M Brewer, Brewer James M, Phillips R, Millington Owain R, Garside Paul, Di Lorenzo Caterina   +14 more
core   +1 more source

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants [PDF]

, 2021
[Figure: see text].The impact of initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting strain on downstream immunity to heterologous variants of concern (VOC) is unknown. Studying a longitudinal healthcare worker cohort, we found
Butler, DK, Joy, G, Liu, S, Manisty, C, Gibbons, JM, Moon, JC, McKnight, Á, Pade, C, Kele, B, Altmann, DM, Fontana, M, Maini, MK, Menacho, K, Brooks, T, Smit, A, Sandoval, DM, Noursadeghi, M, COVIDsortium Immune Correlates Network‡, ., Pieper, F, Treibel, TA, Semper, A, Boyton, RJ, Lin, K-M, Otter, AD, Cutino-Moguel, T, Reynolds, CJ   +25 more
core   +2 more sources

Heterologous immunity between viruses [PDF]

, 2014
Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity.
Selin, Liisa K., Welsh, Raymond M., Che, Jenny Wun-Yue, Brehm, Michael A.   +3 more
core   +1 more source

A high force of Plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in Papua New Guinean children [PDF]

, 2013
When both parasite species are co-endemic, Plasmodium vivax incidence peaks in younger children compared to P. falciparum. To identify differences in the number of blood stage infections of these species and its potential link to acquisition of immunity,
Speed, Terence P., Ingrid Felger (92160), Kiniboro, B, Mueller Ivo, Kathryn L Colborn, Koepfli, Cristian, Terence P. Speed (132229), Speed Terence P., Koepfli, C, Cristian Koepfli, Felger Ingrid, Felger, Ingrid, Kiniboro, Benson, Terence P Speed, Kiniboro Benson, Ingrid Felger, Peter M. Siba (136849), Ivo Mueller (46609), Felger, I, Enmoore Lin, Lin Enmoore, Mueller, Ivo, Benson Kiniboro (191309), Ivo Mueller, Enmoore Lin (137888), Koepfli Cristian, Lin, Enmoore, Lin, E, Kathryn L. Colborn (454997), Colborn Kathryn L., Siba Peter M., Speed, TP, Mueller, I, Colborn, Kathryn L., Siba, PM, Siba, Peter M., Colborn, KL, Peter M Siba, Cristian Koepfli (191306), Benson Kiniboro   +39 more
core   +2 more sources

Immunization with an autotransporter protein of Orientia tsutsugamushi provides protective immunity against scrub typhus. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi infection. Recently, the rapid increase of scrub typhus incidence in several countries within the endemic region has become a serious public health issue.
Na-Young Ha, Prashant Sharma, Gwanghun Kim, Yuri Kim, Chan-Ki Min, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho   +7 more
doaj   +1 more source

Trained-immunity and cross-reactivity for protection: insights from the coronavirus disease 2019 and monkeypox emergencies for vaccine development

Exploration of Immunology, 2023
The emergence and re-emergence of pathogens is a public-health concern, which has become more evident after the coronavirus disease 2019 (COVID-19) pandemic and the monkeypox outbreaks in early 2022.
Amanda Izeli Portilho, Elizabeth De Gaspari   +1 more
doaj   +1 more source