Results 51 to 60 of about 49,719 (277)

Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity

Frontiers in Immunology, 2023
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines.
Larissa Henze, Larissa Henze, Julian Braun, Julian Braun, Lil Meyer-Arndt, Lil Meyer-Arndt, Lil Meyer-Arndt, Lil Meyer-Arndt, Karsten Jürchott, Karsten Jürchott, Maike Schlotz, Janine Michel, Marica Grossegesse, Maike Mangold, Maike Mangold, Manuela Dingeldey, Manuela Dingeldey, Beate Kruse, Beate Kruse, Pavlo Holenya, Norbert Mages, Norbert Mages, Norbert Mages, Ulf Reimer, Maren Eckey, Karsten Schnatbaum, Holger Wenschuh, Bernd Timmermann, Florian Klein, Florian Klein, Florian Klein, Andreas Nitsche, Claudia Giesecke-Thiel, Lucie Loyal, Lucie Loyal, Andreas Thiel, Andreas Thiel   +36 more
doaj   +1 more source

Pathological Features of Heterologous Immunity Are Regulated by the Private Specificities of the Immune Repertoire [PDF]

The American Journal of Pathology, 2010
Heterologous immunity associated with cross-reactive T-cell responses is proposed to contribute to variations among individuals in the pathogenesis of human viral infections. In genetically identical mice with similar infection histories, marked variations in the magnitude and specificities of T-cell responses under conditions of heterologous immunity ...
Siwei, Nie, Sue-Jane, Lin, Sung-kwon, Kim, Raymond M, Welsh, Liisa K, Selin   +4 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Immune mechanisms mediating the heterologous effects of BCG vaccination: a systematic review

Frontiers in Immunology
IntroductionBCG vaccination can have heterologous or non-specific effects (NSE) that confer resistance against pathogens other than its target Mycobacterium tuberculosis, but the underlying mechanisms are not fully understood.MethodsWe conducted a ...
Louis Torracinta, Nino Gogichadze, Rachel Tanner   +2 more
doaj   +1 more source

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

mBio, 2015
The continual threat to global health posed by influenza has led to increased efforts to improve the effectiveness of influenza vaccines for use in epidemics and pandemics.
Brendon Y. Chua, Chinn Yi Wong, Edin J. Mifsud, Kathryn M. Edenborough, Toshiki Sekiya, Amabel C. L. Tan, Francesca Mercuri, Steve Rockman, Weisan Chen, Stephen J. Turner, Peter C. Doherty, Anne Kelso, Lorena E. Brown, David C. Jackson   +13 more
doaj   +1 more source

Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets

npj Vaccines, 2022
The adenovirus (Ad)26 serotype–based vector vaccine Ad26.COV2.S has been used in millions of subjects for the prevention of COVID-19, but potentially elicits persistent anti-vector immunity.
Selina Khan, Nadine C. Salisch, Ana Izquierdo Gil, Satish Boedhoe, Karin Feddes-de Boer, Jan Serroyen, Hanneke Schuitemaker, Roland C. Zahn   +7 more
doaj   +1 more source

Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity

, 2005
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 and other ...
Lynch, Diana M., Truitt, Diana M., Havenga, Menzo J. E., Lemckert, Angelique A. C., Barouch, Dan H., Nanda, Anjali, Ewald, Bonnie A., Sumida, Shawn M., Holterman, Lennart, Vogels, Ronald, Goudsmit, Jaap, Lifton, Michelle A., Gorgone, Darci A.   +12 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity [PDF]

, 2014
International audienceWe have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 ...
Preijers, Frank, van Loenhout, Joke, van Crevel, Reinout, Xavier, Ramnik, Joosten, Leo, Netea, Mihai, G., Jacobs, Cor, Aaby, Peter, Kleinnijenhuis, Johanneke, Benn, Christine Stabell, van Der Meer, Jos, W. M., Quintin, Jessica   +11 more
core   +2 more sources