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How to Employ Trained Immunity and Trained Immunity-Based Vaccines to Inhibit Allergic Inflammation [PDF]

Vaccines
Trained immunity confers protection against subsequent unrelated infections through metabolic and epigenetic reprogramming. Unlike adaptive immunity, trained innate immunity provides broad, non-specific protection against diverse heterologous pathogens ...
Wonho Kim, Dooil Jeoung
doaj   +2 more sources

Probiotics and Trained Immunity

Biomolecules, 2021
The characteristics of innate immunity have recently been investigated in depth in several research articles, and original findings suggest that innate immunity also has a memory capacity, which has been named “trained immunity”.
Naima G. Cortes-Perez, Alejandra de Moreno de LeBlanc, Jorge G. Gomez-Gutierrez, Jean Guy LeBlanc, Luis G. Bermúdez-Humarán   +4 more
doaj   +3 more sources

Trained immunity in the lung [PDF]

eLife
Trained immunity represents a recent concept that elucidates the long-term reprogramming of innate immune cells, enabling them to adapt and respond more effectively to subsequent encounters with diverse pathogens.
Elina Idiiatullina, Dane Parker
doaj   +2 more sources

Evolving our understanding of trained immunity [PDF]

eLife
The articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit “trained immunity” for the development of new vaccines and therapeutics.
Eva Kaufmann, Yahya Sohrabi, Jorge Domínguez-Andrés, Boris Novakovic, Mihai G Netea, Jos WM van der Meer   +5 more
doaj   +2 more sources

Trained Immunity in Health and Disease [PDF]

MedComm
Trained immunity as a critical regulator of host defense and disease pathogenesis bridges the gap between innate and adaptive immunity. For decades, the classic dichotomy of innate immunity and adaptive immunity has shaped our knowledge of immune ...
Meng Yao, Jian Zhou, Jialun Mei, Chuan Gao, Peng Ding, Gan Li, Changqing Zhang, Zhiwei Li, Junjie Gao   +8 more
doaj   +2 more sources

Trained immunity in lung injury and repair [PDF]

Frontiers in Immunology
Trained immunity refers to a phenomenon in which innate immune cells undergo long-lasting functional adaptation following an initial challenge. This paradigm shift in pulmonary immunology reveals that classical innate cells such as alveolar macrophages ...
Thi Hong Nhung Pham, Bisheng Zhou
doaj   +2 more sources

The significance of trained immunity in cancer [PDF]

Frontiers in Immunology
Trained immunity (TI) represented a unique state of innate immune activation, characterized primarily by persistent epigenetic modifications in immune cells.
Junxing Qu, Junxing Qu, Xinya Guo, Xinya Guo, Xinru Wang, Xinru Wang, Huiwen Meng, Huiwen Meng, Peizhi Li, Zhiheng Sun, Zhiheng Sun   +10 more
doaj   +2 more sources

Trained immunity in farm animals [PDF]

Veterinary Research
The mechanisms that enable the innate defence system to “remember its enemies” have opened a new field in immunology, and the evolutionary links among the various defence mechanisms are now being uncovered.
Marisol Báez-Magaña, Nayeli Alva-Murillo, Alejandra Ochoa-Zarzosa, Joel Edmundo López-Meza   +3 more
doaj   +2 more sources

Western lifestyle linked to maladaptive trained immunity [PDF]

eLife
Trained immunity (TI) refers to a state of innate immune cells that, after encountering an initial stimulus and undergoing epigenetic reprogramming and metabolic changes, allows them to respond more effectively to a subsequent challenge.
Aurelia Josephine Merbecks, Christabel Mennicken, Dennis Marinus de Graaf, Kateryna Shkarina, Theresa Wagner, Eicke Latz   +5 more
doaj   +2 more sources

The double-edged nature of trained immunity [PDF]

eLife
Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.
Chrissy M Leopold Wager, Larry S Schlesinger   +1 more
doaj   +2 more sources