Innate immune memory in macrophage differentiation and cardiovascular diseases [PDF]
Inflammation and RegenerationInnate immune memory (trained immunity) refers to the ability of innate immune cells, such as monocytes and macrophages, to retain a long-term imprint of a prior stimulus through epigenetic and metabolic adaptations, enabling amplified responses upon ...
Yukiteru Nakayama, Katsuhito Fujiu
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C1q reprograms innate immune memory [PDF]
Frontiers in ImmunologyInnate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli.
Inge Jonkman +28 more
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Innate Immune Memory in Monocytes and Macrophages: The Potential Therapeutic Strategies for Atherosclerosis [PDF]
Cells, 2022 Atherosclerosis is a complex metabolic disease characterized by the dysfunction of lipid metabolism and chronic inflammation in the intimal space of the vessel. As the most abundant innate immune cells, monocyte-derived macrophages play a pivotal role in
Zhigang Guo +3 more
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Genetic dissection of innate immune memory in Drosophila melanogaster [PDF]
Frontiers in Immunology, 2022 Current studies have demonstrated that innate immunity possesses memory characteristics. Although the molecular mechanisms underlying innate immune memory have been addressed by numerous studies, genetic variations in innate immune memory and the ...
Chang Tang +2 more
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Acid ceramidase regulates innate immune memory [PDF]
Cell Reports, 2023 Summary: Innate immune memory, also called ''trained immunity,'' is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions.
Nils Rother +24 more
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Transcriptome features of innate immune memory in Drosophila. [PDF]
PLoS Genetics, 2022 Immune memory is the ability of organisms to elicit potentiated immune responses at secondary infection. Current studies have revealed that similar to adaptive immunity, innate immunity exhibits memory characteristics (called "innate immune memory ...
Naoyuki Fuse +5 more
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Development of innate immune memory by non-immune cells during Staphylococcus aureus infection depends on reactive oxygen species [PDF]
Frontiers in Immunology, 2023 IntroductionThe mechanisms underlying innate immune memory (trained immunity) comprise epigenetic reprogramming of transcriptional pathways associated with alterations of intracellular metabolism.
Emmanuel Chaumond +8 more
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Drosophila melanogaster as a model to study innate immune memory [PDF]
Frontiers in Microbiology, 2022 Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits.
Marta Arch +14 more
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Redox-signaling in innate immune memory: Similar mechanisms in animals/humans and plants [PDF]
Redox BiologyPlants and animals/humans have evolved sophisticated innate immune systems to cope with microbial attack. Innate immunity implies the presence of membrane-located and intracellular receptors to recognize compounds released by damage or by invading ...
Christian Lindermayr +1 more
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Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease [PDF]
Journal of NeuroinflammationNeuroinflammation is one of the core pathological features of Parkinson’s disease (PD). Innate immune cells play a crucial role in the progression of PD.
Hongtian Dong +14 more
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