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Advances in innate immune memory of macrophages
Immunity is usually classified into two categories: innate immunity and adaptive immunity, distinguished by the process and characteristics of the immunological impact. It was widely assumed that only adaptive immunity possessed memory features; however,
Safir Ullah Khan, Munir Ullah Khan
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In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice
Beta-glucan (β-glucan) is a natural polysaccharide produced by fungi, bacteria, and plants. Although it has been reported that β-glucan enhances innate immune memory responses, it is unclear whether different types of β-glucans display similar immune ...
Hyun Jung Park +7 more
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Immunological Memory in Innate Immunity [PDF]
‘trained immunity’. Trained immunity provides protection against reinfection in a T-/B-cell-independent manner, with nonspecific potentiation of inflammatory reactions and antimicrobial mechanisms playing a central role in these effects [4] . The current issue of the Journal of Innate Immunity presents a series of studies that shed additional light on ...
Netea, M.G., Netea, M.G.
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DAMPs and Innate Immune Training
The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the ...
Elisa Jentho +3 more
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Innate immune memory in cardiometabolic disease. [PDF]
Abstract Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be crucial for these effects. Obesity and associated metabolic complications including hyperglycaemia and dyslipoproteinaemia can induce long-lasting ...
Bahrar H +4 more
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IntroductionThe mechanisms underlying innate immune memory (trained immunity) comprise epigenetic reprogramming of transcriptional pathways associated with alterations of intracellular metabolism.
Emmanuel Chaumond +8 more
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Adaptation and memory in innate immunity [PDF]
Contains fulltext : 172821.pdf (Publisher’s version ) (Open Access)
Netea, M.G. +2 more
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hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke
Innate immune memory is a part of the innate immune system that facilitates the elimination of pathogens. However, it may exacerbate neuropathology. In this study, we found that innate immune memory is detrimental in stroke, because it promotes the acute
Yi-wei Feng +17 more
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The specifics of innate immune memory
Innate immune cells develop specific memory involved in transplant rejection in ...
Dominguez Andres, J., Netea, M.G.
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Emerging Concepts in Innate Lymphoid Cells, Memory, and Reproduction
Members of the innate immune system, innate lymphoid cells (ILCs), encompass five major populations (Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer cells) whose functions include defense against pathogens, surveillance of ...
Rodolfo R. Favaro +4 more
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