Results 1 to 10 of about 178,465 (247)

Methodological Approaches To Assess Innate Immunity and Innate Memory in Marine Invertebrates and Humans [PDF]

Frontiers in Toxicology, 2022
Assessing the impact of drugs and contaminants on immune responses requires methodological approaches able to represent real-life conditions and predict long-term effects.
Manon Auguste, Daniela Melillo, Annunziata Corteggio, Rita Marino, Laura Canesi, Annalisa Pinsino, Paola Italiani, Paola Italiani, Diana Boraschi, Diana Boraschi, Diana Boraschi   +10 more
doaj   +2 more sources

Differential induction of innate memory in porcine monocytes by -glucan or bacillus Calmette-Guerin [PDF]

Innate Immunity, 2021
Innate immunomodulation via induction of innate memory is one mechanism to alter the host’s innate immune response to reduce or prevent disease. Microbial products modulate innate responses with immediate and lasting effects.
Kristen A Byrne, Christopher K Tuggle, Crystal L Loving   +2 more
doaj   +2 more sources

Primary and Memory Response of Human Monocytes to Vaccines: Role of Nanoparticulate Antigens in Inducing Innate Memory [PDF]

Nanomaterials, 2021
Innate immune cells such as monocytes and macrophages are activated in response to microbial and other challenges and mount an inflammatory defensive response. Exposed cells develop the so-called innate memory, which allows them to react differently to a
Mayra M. Ferrari Barbosa, Alex Issamu Kanno, Leonardo Paiva Farias, Mariusz Madej, Gergö Sipos, Silverio Sbrana, Luigina Romani, Diana Boraschi, Luciana C. C. Leite, Paola Italiani   +9 more
doaj   +2 more sources

Environmental stress and nanoplastics’ effects on Ciona robusta: regulation of immune/stress-related genes and induction of innate memory in pharynx and gut [PDF]

Frontiers in Immunology, 2023
In addition to circulating haemocytes, the immune system of the solitary ascidian Ciona robusta relies on two organs, the pharynx and the gut, and encompasses a wide array of immune and stress-related genes. How the pharynx and the gut of C.
Rita Marino, Rita Marino, Daniela Melillo, Paola Italiani, Paola Italiani, Paola Italiani, Diana Boraschi, Diana Boraschi, Diana Boraschi, Diana Boraschi   +9 more
doaj   +2 more sources

The SARS-CoV-2 Nucleoprotein Induces Innate Memory in Human Monocytes [PDF]

Frontiers in Immunology, 2022
The interaction of SARS-CoV-2 with the human immune system is at the basis of the positive or negative outcome of the infection. Monocytes and macrophages, which are major innate immune/inflammatory effector cells, are not directly infected by SARS-CoV-2,
Patricia Urbán, Paola Italiani, Paola Italiani, Diana Boraschi, Diana Boraschi, Diana Boraschi, Sabrina Gioria   +6 more
doaj   +2 more sources

Innate Memory Reprogramming by Gold Nanoparticles Depends on the Microbial Agents That Induce Memory [PDF]

Frontiers in Immunology, 2021
Innate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as
Benjamin J. Swartzwelter, Benjamin J. Swartzwelter, Sara Michelini, Tobias Frauenlob, Francesco Barbero, Alessandro Verde, Anna Chiara De Luca, Victor Puntes, Victor Puntes, Victor Puntes, Albert Duschl, Jutta Horejs-Hoeck, Paola Italiani, Diana Boraschi, Diana Boraschi, Diana Boraschi   +15 more
doaj   +2 more sources

Different Regulation of Interleukin-1 Production and Activity in Monocytes and Macrophages: Innate Memory as an Endogenous Mechanism of IL-1 Inhibition [PDF]

Frontiers in Pharmacology, 2017
Production and activity of interleukin (IL)-1β are kept under strict control in our body, because of its powerful inflammation-promoting capacity. Control of IL-1β production and activity allows IL-1 to exert its defensive activities without causing ...
Mariusz P. Madej, Elfi Töpfer, Diana Boraschi, Paola Italiani   +3 more
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Innate Immune Memory in Invertebrate Metazoans: A Critical Appraisal

Frontiers in Immunology, 2018
The ability of developing immunological memory, a characteristic feature of adaptive immunity, is clearly present also in innate immune responses. In fact, it is well known that plants and invertebrate metazoans, which only have an innate immune system ...
Daniela Melillo, Rita Marino, Paola Italiani, Diana Boraschi, Diana Boraschi   +4 more
doaj   +3 more sources

Potential Role of Gut Microbiota in Induction and Regulation of Innate Immune Memory

Frontiers in Immunology, 2019
The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity.
Shikha Negi, Shikha Negi, Deepjyoti Kumar Das, Susanta Pahari, Susanta Pahari, Sajid Nadeem, Sajid Nadeem, Javed N. Agrewala, Javed N. Agrewala   +8 more
doaj   +3 more sources

Innate immune memory in macrophage differentiation and cardiovascular diseases

Inflammation and Regeneration
Innate immune memory (trained immunity) refers to the ability of innate immune cells, such as monocytes and macrophages, to retain a long-term imprint of a prior stimulus through epigenetic and metabolic adaptations, enabling amplified responses upon ...
Yukiteru Nakayama, Katsuhito Fujiu
doaj   +2 more sources