Innate immune memory in macrophage differentiation and cardiovascular diseases
Inflammation and RegenerationInnate immune memory (trained immunity) refers to the ability of innate immune cells, such as monocytes and macrophages, to retain a long-term imprint of a prior stimulus through epigenetic and metabolic adaptations, enabling amplified responses upon ...
Yukiteru Nakayama, Katsuhito Fujiu
doaj +3 more sources
C1q reprograms innate immune memory [PDF]
Frontiers in ImmunologyInnate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli.
Inge Jonkman +28 more
doaj +5 more sources
Methodological Approaches To Assess Innate Immunity and Innate Memory in Marine Invertebrates and Humans [PDF]
Frontiers in Toxicology, 2022 Assessing the impact of drugs and contaminants on immune responses requires methodological approaches able to represent real-life conditions and predict long-term effects.
Manon Auguste +10 more
doaj +2 more sources
Primary and Memory Response of Human Monocytes to Vaccines: Role of Nanoparticulate Antigens in Inducing Innate Memory [PDF]
Nanomaterials, 2021 Innate immune cells such as monocytes and macrophages are activated in response to microbial and other challenges and mount an inflammatory defensive response. Exposed cells develop the so-called innate memory, which allows them to react differently to a
Mayra M. Ferrari Barbosa +9 more
doaj +2 more sources
Differential induction of innate memory in porcine monocytes by -glucan or bacillus Calmette-Guerin [PDF]
Innate Immunity, 2021 Innate immunomodulation via induction of innate memory is one mechanism to alter the host’s innate immune response to reduce or prevent disease. Microbial products modulate innate responses with immediate and lasting effects.
Kristen A Byrne +2 more
doaj +2 more sources
Environmental stress and nanoplastics’ effects on Ciona robusta: regulation of immune/stress-related genes and induction of innate memory in pharynx and gut [PDF]
Frontiers in Immunology, 2023 In addition to circulating haemocytes, the immune system of the solitary ascidian Ciona robusta relies on two organs, the pharynx and the gut, and encompasses a wide array of immune and stress-related genes. How the pharynx and the gut of C.
Rita Marino +9 more
doaj +2 more sources
The SARS-CoV-2 Nucleoprotein Induces Innate Memory in Human Monocytes [PDF]
Frontiers in Immunology, 2022 The interaction of SARS-CoV-2 with the human immune system is at the basis of the positive or negative outcome of the infection. Monocytes and macrophages, which are major innate immune/inflammatory effector cells, are not directly infected by SARS-CoV-2,
Patricia Urbán +6 more
doaj +2 more sources
Innate Memory Reprogramming by Gold Nanoparticles Depends on the Microbial Agents That Induce Memory [PDF]
Frontiers in Immunology, 2021 Innate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as
Benjamin J. Swartzwelter +15 more
doaj +2 more sources
Helicobacter pylori Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS
Frontiers in Immunology, 2022 Infection with Helicobacter pylori (H. pylori) affects almost half of the world’s population and is a major cause of stomach cancer. Although immune cells react strongly to this gastric bacterium, H.
Tobias Frauenlob +9 more
doaj +1 more source
Advances in innate immune memory of macrophages
Exploration of Immunology, 2022 Immunity is usually classified into two categories: innate immunity and adaptive immunity, distinguished by the process and characteristics of the immunological impact. It was widely assumed that only adaptive immunity possessed memory features; however,
Safir Ullah Khan, Munir Ullah Khan
doaj +1 more source