Results 31 to 40 of about 178,465 (247)
The specifics of innate immune memory
Science, 2020 Innate immune cells develop specific memory involved in transplant rejection in ...
Dominguez Andres, J., Netea, M.G.
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Frontiers in Immunology, 2020 The capacity of engineered nanoparticles to activate cells of the innate immune system, in particular monocytes and macrophages, is considered at the basis of their toxic/inflammatory effects.
Paola Italiani +2 more
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Epigenetic regulation of innate immune memory in microglia [PDF]
Journal of Neuroinflammation, 2021 Abstract Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative slow turnover is that microglia can serve as a long-term memory for inflammatory or ...
Xiaoming Zhang +8 more
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Innate Immune Memory in Macrophages
Newborn, 2023 Macrophages have been recognized as the primary mediators of innate immunity starting from embryonic/fetal development. Macrophage-mediated defenses may not be as antigen-specific as adaptive immunity, but increasing information suggests that these responses do strengthen with repeated immunological triggers. The concept of innate memory in macrophages
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DAMPs and Innate Immune Training
Frontiers in Immunology, 2021 The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the ...
Elisa Jentho +3 more
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Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes. [PDF]
PLoS Pathogens, 2011 While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are capable of mediating memory responses. We now show that an innate memory immune response is generated
Geoffrey O Gillard +7 more
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Trained Immunity: A Memory for Innate Host Defense [PDF]
Cell Host & Microbe, 2011 Immune responses in vertebrates are classically divided into innate and adaptive, with only the latter being able to build up immunological memory. However, although lacking adaptive immune responses, plants and invertebrates are protected against reinfection with pathogens, and invertebrates even display transplant rejection.
Netea, M.G. +2 more
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Innate immunological memory: from plants to animals [PDF]
Current Opinion in Immunology, 2020 Immunological memory is defined by the ability of the host to recognise and mount a robust secondary response against a previously encountered pathogen. Classic immune memory is an evolutionary adaptation of the vertebrate immune system that has been attributed to adaptive lymphocytes, including T and B cells.
Jessica, Sharrock, Joseph C, Sun
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Assessing Immunological Memory in the Solitary Ascidian Ciona robusta
Frontiers in Immunology, 2019 The immune defensive mechanisms active in the solitary ascidian Ciona robusta include phagocytic and encapsulating activity, largely brought about by phagocytic cells within the haemocyte population, the presence of complement components, which have been
Daniela Melillo +5 more
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Frontiers in Immunology, 2023 IntroductionThe mechanisms underlying innate immune memory (trained immunity) comprise epigenetic reprogramming of transcriptional pathways associated with alterations of intracellular metabolism.
Emmanuel Chaumond +8 more
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