Results 31 to 40 of about 2,229,414 (244)

DAMPs and Innate Immune Training

Frontiers in Immunology, 2021
The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the ...
Elisa Jentho, Elisa Jentho, Sebastian Weis, Sebastian Weis   +3 more
doaj   +1 more source

Innate Immune Memory in Invertebrate Metazoans: A Critical Appraisal

Frontiers in Immunology, 2018
The ability of developing immunological memory, a characteristic feature of adaptive immunity, is clearly present also in innate immune responses. In fact, it is well known that plants and invertebrate metazoans, which only have an innate immune system ...
Daniela Melillo, Rita Marino, Paola Italiani, Diana Boraschi, Diana Boraschi   +4 more
doaj   +1 more source

Development of innate immune memory by non-immune cells during Staphylococcus aureus infection depends on reactive oxygen species

Frontiers in Immunology, 2023
IntroductionThe mechanisms underlying innate immune memory (trained immunity) comprise epigenetic reprogramming of transcriptional pathways associated with alterations of intracellular metabolism.
Emmanuel Chaumond, Sandrine Peron, Nathalie Daniel, Yann Le Gouar, Éric Guédon, David L. Williams, Yves Le Loir, Gwénaël Jan, Nadia Berkova   +8 more
doaj   +1 more source

Assessing Immunological Memory in the Solitary Ascidian Ciona robusta

Frontiers in Immunology, 2019
The immune defensive mechanisms active in the solitary ascidian Ciona robusta include phagocytic and encapsulating activity, largely brought about by phagocytic cells within the haemocyte population, the presence of complement components, which have been
Daniela Melillo, Rita Marino, Giacomo Della Camera, Paola Italiani, Diana Boraschi, Diana Boraschi   +5 more
doaj   +1 more source

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]

, 2012
peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Brinkman, Fiona S. L., Laird, Matthew R, Amir K. Foroushani, David J. Lynn, Anastasia Sribnaia, Lynn, David J, Lo, Raymond, Raymond Lo, Foroushani, Amir K., Winsor, Geoffrey L, Breuer, Karin, Chen, Carol, Robert E. W. Hancock, Matthew R. Laird, Carol Chen, Geoffrey L. Winsor, Sribnaia, Anastasia, Hancock, Robert E.W., Karin Breuer, Fiona S. L. Brinkman   +19 more
core   +1 more source

Microarray expression analysis of genes involved in innate immune memory in peritoneal macrophages

Genomics Data, 2016
Immunological memory has been believed to be a feature of the adaptive immune system for long period, but recent reports suggest that the innate immune system also exhibits memory-like reaction.
Keisuke Yoshida, Claire Renard-Guillet, Kentaro Inoue, Katsuhiko Shirahige, Mariko Okada-Hatakeyama, Shunsuke Ishii   +5 more
doaj   +1 more source

Recombinant BCG Expressing the Subunit 1 of Pertussis Toxin Induces Innate Immune Memory and Confers Protection against Non-Related Pathogens

Vaccines, 2022
BCG has shown the ability to induce protection against unrelated pathogens, which likely depends on an immune mechanism known as innate immune memory or trained immunity.
Alex I. Kanno, Diana Boraschi, Luciana C. C. Leite, Dunia Rodriguez   +3 more
doaj   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Kishore, U, Domenico Marco Bonifati, Abhishek Shastri, Shastri, A, Bonifati, DM, Uday Kishore   +5 more
core   +1 more source

Induction of Innate Immune Memory by Engineered Nanoparticles: A Hypothesis That May Become True

Frontiers in Immunology, 2017
Innate immune memory is the capacity of cells of the innate immune system, such as monocytes and macrophages, to react differently to an inflammatory or infectious challenge if previously exposed to the same or to another agent. Innate immune memory is a
Paola Italiani, Diana Boraschi
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source