Results 11 to 20 of about 178,465 (247)

C1q reprograms innate immune memory

Frontiers in Immunology
Innate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli.
Inge Jonkman, Maaike M. E. Jacobs, Yutaka Negishi, Yutaka Negishi, Julia I. P. van Heck, Vasiliki Matzaraki, Joost H. A. Martens, Marijke Baltissen, Michiel Vermeulen, Zahi A. Fayad, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Luuk B. Hilbrands, Leo A. B. Joosten, Leo A. B. Joosten, Mihai G. Netea, Mihai G. Netea, Musa M. Mhlanga, Musa M. Mhlanga, Nils Rother, Raphaël Duivenvoorden, Raphaël Duivenvoorden, Raphaël Duivenvoorden   +28 more
doaj   +6 more sources

The Role of Cell Metabolism in Innate Immune Memory [PDF]

Journal of Innate Immunity, 2020
Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections ...
Anaisa Valido Ferreira, Jorge Domiguéz-Andrés, Mihai Gheorghe Netea   +2 more
doaj   +5 more sources

Innate memory T cells. [PDF]

Adv Immunol, 2015
Memory T cells are usually considered to be a feature of a successful immune response against a foreign antigen, and such cells can mediate potent immunity. However, in mice, alternative pathways have been described, through which naïve T cells can acquire the characteristics and functions of memory T cells without encountering specific foreign antigen
Jameson SC, Lee YJ, Hogquist KA.
europepmc   +5 more sources

Innate (learned) memory

Journal of Allergy and Clinical Immunology, 2023
With the growing body of evidence, it is now clear that not only adaptive immune cells but also innate immune cells can mount a more rapid and potent nonspecific immune response to subsequent exposures. This process is known as trained immunity or innate (learned) immune memory. This review discusses the different immune and nonimmune cell types of the
Al, B., Suen, T.K., Placek, K., Netea, M.G.   +3 more
openaire   +3 more sources

Helicobacter pylori Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS

Frontiers in Immunology, 2022
Infection with Helicobacter pylori (H. pylori) affects almost half of the world’s population and is a major cause of stomach cancer. Although immune cells react strongly to this gastric bacterium, H.
Tobias Frauenlob, Tobias Frauenlob, Theresa Neuper, Muamera Mehinagic, Hieu-Hoa Dang, Diana Boraschi, Diana Boraschi, Diana Boraschi, Jutta Horejs-Hoeck, Jutta Horejs-Hoeck   +9 more
doaj   +1 more source

Advances in innate immune memory of macrophages

Exploration of Immunology, 2022
Immunity is usually classified into two categories: innate immunity and adaptive immunity, distinguished by the process and characteristics of the immunological impact. It was widely assumed that only adaptive immunity possessed memory features; however,
Safir Ullah Khan, Munir Ullah Khan
doaj   +1 more source

Innate Allorecognition and Memory in Transplantation [PDF]

Frontiers in Immunology, 2020
Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation and how to target it is highly ...
Daqiang Zhao, Daqiang Zhao, Khodor I. Abou-Daya, Hehua Dai, Martin H. Oberbarnscheidt, Martin H. Oberbarnscheidt, Martin H. Oberbarnscheidt, Xian C. Li, Fadi G. Lakkis, Fadi G. Lakkis, Fadi G. Lakkis   +10 more
openaire   +3 more sources

Immunological Memory in Innate Immunity [PDF]

Journal of Innate Immunity, 2013
‘trained immunity’. Trained immunity provides protection against reinfection in a T-/B-cell-independent manner, with nonspecific potentiation of inflammatory reactions and antimicrobial mechanisms playing a central role in these effects [4] . The current issue of the Journal of Innate Immunity presents a series of studies that shed additional light on ...
Netea, M.G., Netea, M.G.
openaire   +4 more sources

In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice

Molecules, 2023
Beta-glucan (β-glucan) is a natural polysaccharide produced by fungi, bacteria, and plants. Although it has been reported that β-glucan enhances innate immune memory responses, it is unclear whether different types of β-glucans display similar immune ...
Hyun Jung Park, Sung Won Lee, Yun Hoo Park, Tae-Cheol Kim, Sujin Lee, Seyeong Lee, Luc Van Kaer, Seokmann Hong   +7 more
doaj   +1 more source

Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

eLife, 2021
Immunity to malaria is often considered slow to develop but this only applies to defense mechanisms that function to eliminate parasites (resistance).
Wiebke Nahrendorf, Alasdair Ivens, Philip J Spence   +2 more
doaj   +1 more source