Results 51 to 60 of about 2,229,414 (244)

The Role of Cell Metabolism in Innate Immune Memory

Journal of Innate Immunity, 2020
Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections ...
Anaisa Valido Ferreira, Jorge Domiguéz-Andrés, Mihai Gheorghe Netea   +2 more
doaj   +1 more source

Immune memory characteristics of innate lymphoid cells

, 2019
Contains fulltext : 206777.pdf (Publisher’s version ) (Open Access)PURPOSE OF REVIEW: Immune memory is essential for host defense against invaders and it is also used as a basis for vaccine development.
Katarzyna Placek, Placek, K., Placek, Katarzyna, Mihai G. Netea, Schultze, J.L., Joachim L. Schultze, Netea, M.G., Net, Mihai G., Schultze, Joachim L.   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Emerging Concepts in Innate Lymphoid Cells, Memory, and Reproduction

Frontiers in Immunology, 2022
Members of the innate immune system, innate lymphoid cells (ILCs), encompass five major populations (Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer cells) whose functions include defense against pathogens, surveillance of ...
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujčič, Udo R. Markert   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Potential Role of Gut Microbiota in Induction and Regulation of Innate Immune Memory

Frontiers in Immunology, 2019
The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity.
Shikha Negi, Shikha Negi, Deepjyoti Kumar Das, Susanta Pahari, Susanta Pahari, Sajid Nadeem, Sajid Nadeem, Javed N. Agrewala, Javed N. Agrewala   +8 more
doaj   +1 more source

Immune memory: an evolutionary perspective

Human Vaccines & Immunotherapeutics, 2021
The innate immune system, through pattern recognition receptors, intercepts any kind of pathogen and reacts through chemotactic, phagocyting, cytokines-secreting and cell-killing mechanisms in a very quick and effective way.
Beniamino Palmieri, Maria Vadala’, Lucia Palmieri   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Innate Immune Memory and the Host Response to Infection

, 2022
Unlike the adaptive immune system, the innate immune system has classically been characterized as being devoid of memory functions. However, recent research shows that innate myeloid and lymphoid cells have the ability to retain memory of prior pathogen ...
Williams, David L., Patil, Naeem K., Sherwood, Edward R., Hernandez, Antonio, McBride, Margaret A., Owen, Allison M., Stothers, Cody L., Bohannon, Julia K., Burelbach, Katherine R.   +8 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source