Results 31 to 40 of about 3,110,551 (267)

Epigenetic regulation of innate immune memory in microglia [PDF]

Journal of Neuroinflammation, 2021
Abstract Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative slow turnover is that microglia can serve as a long-term memory for inflammatory or ...
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W.G.M. Boddeke, Bart J.L. Eggen, Susanne M. Kooistra   +8 more
openaire   +5 more sources

Pleiotropic Mucosal Innate Immune Memory in the Gastrointestinal Tract. [PDF]

Int J Mol Sci
Research in the past fifteen years has established that innate immune cells can develop immune memory, termed trained immunity. Trained innate immune cells exhibit distinct lasting epigenetic and metabolic changes that prime these cells upon repeated ...
Cohen RH, Colgan SP, Cartwright IM.
europepmc   +2 more sources

Leprosy and Immune System An Insight into the Innate Immune System [PDF]

, 2021
Innate immunity is a host immune mechanism to defend itself promptly. It includes physical and chemical barriers, cells in the circulation and tissues, several plasma proteins, and immune cells constituting phagocytic cells (monocytes/macrophages and ...
Budiamal, S, Christopher, PM, Putri, Winawati Eka   +2 more
core   +1 more source

Chitin modulates innate immune responses of keratinocytes. [PDF]

, 2011
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian, Koller, Barbara, Thomas Ruzicka, Korting Hans Christian, Rupec Rudolph, Müller-Wiefel Alisa Sophie, Alisa Sophie Müller-Wiefel, Müller-Wiefel, Alisa Sophie, Rudolph Rupec, Koller Barbara, Hans Christian Korting, Ruzicka, Thomas, Barbara Koller, Ruzicka Thomas, Rupec, Rudolph   +14 more
core   +2 more sources

Trained Immunity: A Memory for Innate Host Defense [PDF]

Cell Host & Microbe, 2011
Immune responses in vertebrates are classically divided into innate and adaptive, with only the latter being able to build up immunological memory. However, although lacking adaptive immune responses, plants and invertebrates are protected against reinfection with pathogens, and invertebrates even display transplant rejection.
Netea, M.G., Quintin, J., Meer, J.W.M. van der   +2 more
openaire   +3 more sources

Trained Immunity and Local Innate Immune Memory in the Lung [PDF]

Cell, 2018
Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNγ release from effector CD8+ lymphocytes initiating this process.
Netea, M.G., Netea, M.G., Joosten, L.A.B., Joosten, L.A.B.   +3 more
openaire   +3 more sources

Recombinant BCG Expressing the Subunit 1 of Pertussis Toxin Induces Innate Immune Memory and Confers Protection against Non-Related Pathogens

Vaccines, 2022
BCG has shown the ability to induce protection against unrelated pathogens, which likely depends on an immune mechanism known as innate immune memory or trained immunity.
Alex I. Kanno, Diana Boraschi, Luciana C. C. Leite, Dunia Rodriguez   +3 more
doaj   +1 more source

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

Microarray expression analysis of genes involved in innate immune memory in peritoneal macrophages

Genomics Data, 2016
Immunological memory has been believed to be a feature of the adaptive immune system for long period, but recent reports suggest that the innate immune system also exhibits memory-like reaction.
Keisuke Yoshida, Claire Renard-Guillet, Kentaro Inoue, Katsuhiko Shirahige, Mariko Okada-Hatakeyama, Shunsuke Ishii   +5 more
doaj   +1 more source

Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes. [PDF]

PLoS Pathogens, 2011
While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are capable of mediating memory responses. We now show that an innate memory immune response is generated
Geoffrey O Gillard, Maytal Bivas-Benita, Avi-Hai Hovav, Lauren E Grandpre, Michael W Panas, Michael S Seaman, Barton F Haynes, Norman L Letvin   +7 more
doaj   +1 more source