Results 51 to 60 of about 3,110,551 (267)

Cross-Generational Impact of Innate Immune Memory Following Pregnancy Complications

Cells, 2022
Pregnancy complications can have long-term negative effects on the health of the affected mothers and their children. In this review, we highlight the underlying inflammatory etiologies of common pregnancy complications and discuss how aberrant ...
Nakeisha A. Lodge-Tulloch, Alexa J. Toews, Aline Atallah, Tiziana Cotechini, Sylvie Girard, Charles H. Graham   +5 more
doaj   +1 more source

Innate immunity against HIV: a priority target for HIV prevention research. [PDF]

, 2010
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W, ROMARIS M, LINDBLAD E, DONCEL G, BORROW P, Persephone Borrow, Borrow, P, LEHNER T, DE MAGISTRIS MT, Shattock, Robin J., MEDAGLINI, DONATA, Vyakarnam, Annapurna, PATTERSON S, Annapurna Vyakarnam, POLI G, EUROPRISE WORKING GROUP BOGERS W, KIRCHHOFF F, KELLY C, TOWERS G, SILVESTRI G, DEBRE P, Robin J Shattock, Shattock, RJ, SHATTOCK RJ, Vyakarnam Annapurna, Borrow, Persephone, Borrow Persephone, GOODIER M, null null, SPECK R, EUROPRISE Working Group, GEIJTENBEEK T, Vyakarnam, A, Shattock Robin J, WAGNER H., VYAKARNAM A   +35 more
core   +1 more source

Transcriptomics and quantitative proteomics reveal changes after second stimulation of bone marrow-derived macrophages from lupus-prone MRL/lpr mice

Frontiers in Immunology, 2022
Innate immune memory can cause the occurrence and exacerbation of autoimmune diseases, and it is as well as being strongly associated with the pathogenesis of systemic lupus erythematosus (SLE), however, the specific mechanism remains to be further ...
Keyue Chen, Tiyun Wu, Danyan Wang, Rong Li, Xiangfeng Shen, Ting Zhao, Keiko Ozato, Rongqun Li   +7 more
doaj   +1 more source

MST kinases in innate immune signaling [PDF]

, 2017
The mammalian STE20-like (MST) protein kinases are composed of MST1, MST2, MST3, MST4 and YSK1. They play crucial roles in cell growth, migration, polarity and apoptosis. Dysfunction of these kinases often leads to diseases.
Zhaocai Zhou, Zhubing Shi
core   +1 more source

Induction of Innate Immune Memory by Engineered Nanoparticles: A Hypothesis That May Become True

Frontiers in Immunology, 2017
Innate immune memory is the capacity of cells of the innate immune system, such as monocytes and macrophages, to react differently to an inflammatory or infectious challenge if previously exposed to the same or to another agent. Innate immune memory is a
Paola Italiani, Diana Boraschi
doaj   +1 more source

Immunological memory within the innate immune system [PDF]

The EMBO Journal, 2014
Immune memory has traditionally been the domain of the adaptive immune system, present only in antigen-specific T and B cells. The purpose of this review is to summarize the evidence for immunological memory in lower organisms (which are not thought to possess adaptive immunity) and within specific cell subsets of the innate immune system.
Sun, J. C., Ugolini, S., Vivier, E.
openaire   +2 more sources

Antiviral Defense and Innate Immune Memory in the Oyster [PDF]

Viruses, 2018
The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas combined with next-generation sequencing techniques has
Timothy Green, Peter Speck
openaire   +4 more sources

A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata.

PLoS Pathogens, 2016
Discoveries made over the past ten years have provided evidence that invertebrate antiparasitic responses may be primed in a sustainable manner, leading to the failure of a secondary encounter with the same pathogen.
Silvain Pinaud, Julien Portela, David Duval, Fanny C Nowacki, Marie-Aude Olive, Jean-François Allienne, Richard Galinier, Nolwenn M Dheilly, Sylvie Kieffer-Jaquinod, Guillaume Mitta, André Théron, Benjamin Gourbal   +11 more
doaj   +1 more source

Innate Immune Memory: The Latest Frontier of Adjuvanticity [PDF]

Journal of Immunology Research, 2015
Recent findings in the field of immune memory have demonstrated that B and T cell mediated immunity following infections are enhanced by the so-calledtrained immunity. This effect has been most extensively investigated for the tuberculosis vaccine strain Bacillus Calmette-Guérin (BCG).
Toepfer Elfi, Boraschi Diana, Italiani Paola   +2 more
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source