Results 61 to 70 of about 3,110,551 (267)

Advances in immune response to pulmonary infection: Nonspecificity, specificity and memory

Chronic Diseases and Translational Medicine, 2023
The lung immune response consists of various cells involved in both innate and adaptive immune processes. Innate immunity participates in immune resistance in a nonspecific manner, whereas adaptive immunity effectively eliminates pathogens through ...
Jianqiao Xu, Lixin Xie
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites [PDF]

, 2014
Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of ...
Savill Nicholas Jon, Lars Raberg, Nick Savill, Nicholas Jon Savill, Råberg Lars, Jayanthi Santhanam, Nicholas Jon Savill (513813), Santhanam, Jayanthi, Råberg, Lars, Andrew F Read, Jayanthi Santhanam (513812), Santhanam Jayanthi, Råberg, Lars,, Savill, Nicholas Jon, Andrew Read, Andrew F. Read (130517), Read, Andrew F, Lars Råberg (240621), Read Andrew F., Andrew F. Read   +19 more
core   +1 more source

Epigenetic control of innate and adaptive immune memory [PDF]

Nature Immunology, 2018
Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and 'memory' NK
Colleen M. Lau, Nicholas M. Adams, Clair D. Geary, Orr-El Weizman, Moritz Rapp, Yuri Pritykin, Christina S. Leslie, Joseph C. Sun   +7 more
openaire   +2 more sources

Innate immune memory and its application to artificial immune systems

The Journal of Supercomputing, 2022
The study of innate immune-based algorithms is an important research domain in Artificial Immune System (AIS), such as Dendritic Cell Algorithm (DCA), Toll-Like Receptor algorithm (TLRA). The parameters in these algorithms usually require either manually pre-defined usually provided by the immunologists, or empirically derived from the training dataset,
Dongmei Wang, Yiwen Liang, Hongbin Dong, Chengyu Tan, Zhenhua Xiao, Sai Liu   +5 more
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Kishore, U, Domenico Marco Bonifati, Abhishek Shastri, Shastri, A, Bonifati, DM, Uday Kishore   +5 more
core   +1 more source

Memory-like innate lymphoid cells in the pathogenesis of asthma

Frontiers in Immunology, 2022
Innate lymphoid cells (ILCs) are recently discovered innate immune cells that reside and self-renew in mucosal tissues and serve as the first line of defense against various external insults.
Jongho Ham, Jongho Ham, Jongho Ham, MinYeong Lim, MinYeong Lim, MinYeong Lim, Dongmo Kim, Dongmo Kim, Dongmo Kim, Hye Young Kim, Hye Young Kim, Hye Young Kim, Hye Young Kim   +12 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Induction of Innate Immune Memory by Engineered Nanoparticles in Monocytes/Macrophages: From Hypothesis to Reality

Frontiers in Immunology, 2020
The capacity of engineered nanoparticles to activate cells of the innate immune system, in particular monocytes and macrophages, is considered at the basis of their toxic/inflammatory effects.
Paola Italiani, Giacomo Della Camera, Diana Boraschi   +2 more
doaj   +1 more source